Programme Code Index

O0002 Human Movement Variability and Falls in the Elderly Nick Stergiou, Joao Vaz, Andreas Skiadopoulos
University of Nebraska at Omaha, Omaha, USA.
O0003 Influence of head orientation on gait stability in young adults, dancers and older adults Rina Magnani1,2, Sjoerd Bruijn2, Marcus Fraga Vieira1, Jaap van Dieën2
1Universidade Federal de Goiás, Goiânia, Brazil. 2Vrije Universiteit, Amsterdam, Netherlands.
O0004 Gait variability in patients with COPD during a self-paced 6-minute walk test Wai-Yan Liu1,2, Martijn A. Spruit1,2, Jeannet M. Delbressine1, Paul J. Willems2, Frits M.E. Franssen1,2, Emiel F.M. Wouters2,1, Kenneth Meijer2
1Ciro, Horn, Netherlands. 2Maastricht University Medical Centre+, Maastricht, Netherlands.
O0006 Using zero-moment point to predict single versus multiple step recovery from forward loss of balance Nicolas Vivaldi1, Jeffrey Reinbolt1, Rod Barrett2
1University of Tennessee, Knoxville, USA. 2Griffith University, Gold Coast, Australia.
O0010 Characteristics of Head Impact Exposure in Concussed and Non-Concussed College American Football Athletes Brian Stemper1,2,3, Alok Shah1,3, Steven Rowson4, Stefan Duma4, Jason Mihalik5, Jaroslaw Harezlak6, Thomas McAllister6, Steven Broglio7, Michael McCrea1,3
1Medical College of Wisconsin, Milwaukee, USA. 2Marquette University, Milwaukee, USA. 3Zablocki Veterans Affairs Medical Center, Milwaukee, USA. 4Virginia Tech, Blacksburg, USA. 5University of North Carolina, Chapel Hill, USA. 6Indiana University, Bloomington, USA. 7University of Michigan, Ann Arbor, USA.
O0012 High-Speed Biplane X-ray Head Impact Experiments in the Göttingen Minipig Elizabeth McNeil1, Allison Guettler1, Pamela VandeVord1,2, Warren Hardy1
1Virginia Tech, Blacksburg, USA. 2Salem VA Medical Center, Salem, USA.
O0013 Characterization of in vivo 3D skull-brain motion during multi-directional dynamic head vibration using magnetic resonance elastography Ziying Yin1, Yi Sui1, Joshua D. Trzasko1, Phillip J. Rossman1, Armando Manduca2, Richard L. Ehman1, John Huston1
1Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, USA. 2Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA.
O0014 Nonlinear Dynamical Behavior of Deep White Matter in the Human Brain Javid Abderezaei1, Wei Zhao2, Efe Ozkaya1, Songbai Ji2, Kaveh Laksari3, Mehmet Kurt1,4
1Stevens Institute of Technology, Hoboken, USA. 2Worcester Institute of Polytechnic, Worcester, USA. 3University of Arizona, Tucson, USA. 4Icahn School of Medicine at Mount Sinai, New York, USA.
O0017 Unravelling the aortic microstructure: synchrotron-based quasi-static pressure inflation of the mouse carotid artery Bram Trachet1,2, Mauro Ferraro1, Lydia Aslanidou1, Patrick Segers2, Nikolaos Stergiopulos1
1EPFL, Lausanne, Switzerland. 2Ghent University, Ghent, Belgium.
O0018 Microscopic deformation of the aorta during pressurization based on SHG and two-photon microscopy Shukei Sugita1, Masaya Katoh1, Masanori Nakamura1, Takeo Matsumoto2,1
1Nagoya Institute of Technology, Nagoya, Japan. 2Nagoya University, Nagoya, Japan.
O0020 Application of Digital Image Correlation to determine the multiaxial mechanical properties of ascending, descending and abdominal porcine aorta. Juan A Peña1, Miguel A Martínez2,3, Estefania Peña2,3
1Aragon Institute of Engineering Research, Department of Management and Manufacturing Engineering,. University of Zaragoza, Zaragoza, Spain. 2Aragon Institute of Engineering Research, Mechanical Engineering Department. University of Zaragoza, Zaragoza, Spain. 3CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain, Zaragoza, Spain.
O0021 Identification of regional mechanical properties in murine thoracic aortic aneurysms Matthew R. Bersi1,2, Chiara Bellini3,2, Jay D. Humphrey2, Stéphane Avril4
1Vanderbilt University, Nashville, USA. 2Yale University, New Haven, USA. 3Northeastern University, Boston, USA. 4École des Mines de Saint-Étienne, Saint-Étienne, France.
O0022 Obtaining biomechanical properties of corneal tissue in-vivo using a non-contact method Ahmed Elsheikh1,2, Kai-Jung Chen1, Ashkan Eliasy1, Riccardo Vinciguerra3
1School of Engineering, Liverpool, United Kingdom. 2NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom. 3St Paul’s Eye Unit, Royal Liverpool and Broadgreen University Hospital, Liverpool, United Kingdom.
O0023 The relationship between tensile strain and connective tissue architecture in the optic nerve head (ONH) of human eyes Crawford Downs1, Kapil Krishnan1, Vincent Libertiaux2, Rafael Grytz1, Christopher Girkin1
1The University of Alabama at Birmingham, Birmingham, USA. 2University of Liege, Liege, Belgium.
O0024 A Preliminary experimental study on creep characteristics of cornea after refractive surgery Haixia Zhang1,2, Di Zhang1,2, Xiao Qin1,2, Lin Li1,2
1School of Biomedical Engineering, Capital Medical University, Beijing, China. 2Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Beijing, China.
O0025 Effect of Intraocular Pressure and Cerebrospinal Fluid Pressure Pulsations on Lamina Cribrosa Deformations Yuejiao Jin1, Xiaofei Wang1, Liang Zhang1, Jost B. Jonas2, Tin Aung3,1, Leopold Schmetterer3,1,4, Michaël J.A. Girard1,3
1National University of Singapore, Singapore, Singapore. 2Ruprecht-Karls-University Heidelberg, Heidelberg, Germany. 3Singapore Eye Research Institute, Singapore, Singapore. 4Medical University of Vienna, Vienna, Austria.
O0026 The role of endogenous proteins on the interfacial properties between Silicone oil and aqueous solution in vitrectomized eyes Irene Nepita1, Rodolfo Repetto1, Jan O. Pralits1, Mario Romano2, Francesca Ravera3, Eva Santini3, Libero Liggieri3
1Dept. of Civil, Chemical and Environmental Engineering, University of Genoa, Genoa, Italy. 2Dept. of Biomedical Sciences, Humanitas University, Bergamo, Italy. 3Institute for Condensed Matter Chemistry and Energy Technologies, CNR, Genoa, Italy.
O0030 Muscle shape changes and the role of intramuscular springs. Thomas Roberts1, Emanuel Azizi2, Carolyn Eng1
1Brown University, Providence, USA. 2University of California, Irvine, Irvine, USA.
O0031 Rate of force development during isometric contraction and induced pre-activated stretch conditions in the human adductor pollicis muscle Elske Kranenburg1, Lars Kooijman2, Rafael Fortuna3, Walter Herzog3
1The Hague University of Applied Sciences, The Hague, Netherlands. 2Delft University of Technology, Delft, Netherlands. 3University of Calgary, Calgary, Canada.
O0032 Three-dimensional architecture of the whole human soleus muscle in vivo Bart Bolsterlee1,2, Taija Finni3, Arkiev D'Souza1,2, Junya Eguchi1,2, Rob Herbert1,2
1Neuroscience Research Australia, Sydney, Australia. 2University of New South Wales, Sydney, Australia. 3University of Jyväskylä, Jyväskylä, Finland.
O0033 The effect of habitual rearfoot and mid-/forefoot striking on muscle fascicle and tendon behavior during running Wannes Swinnen1,2, Wouter Hoogkamer3, Jeroen Aeles2, Tijs Delabastita2, Benedicte Vanwanseele2
1German Sport University Cologne, Cologne, Germany. 2KU Leuven, Leuven, Belgium. 3University of Colorado Boulder, Boulder, USA.
O0035 Intramuscular Pressure of Tibialis Anterior Correlates with Ankle Torque but does not Follow Length-Tension Relationship Filiz Ates1, Krista Coleman-Wood1, William Litchy2, Kenton R. Kaufman1
1Motion Analysis Laboratory, Department of Orthopedic Surgery, Mayo Clinic, Rochester, USA. 2Department of Neurology, Mayo Clinic, Rochester, USA.
O0038 Molecular Hyperthermia to Manipulate Individual Proteins: Feasibility and Non-Arrhenius Kinetics Daipayan Sarkar1, Peiyuan Kang1, Zhenpeng Qin1,2
1The University of Texas at Dallas, Richardson,TX, USA. 2The University of Texas at Soutwestern Medical Center, Dallas, TX, USA.
O0043 Big Data and machine learning to create physics-based personalised computational neuromusculoskeletal models David Lloyd,
Gold Coast Orthopaedics Research and Education Alliance, Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia. School of Allied Health Sciences, Griffith University, Gold Coast, Australia.
O0044 Form and Function: The Gait Adaptation of Chinese Bound Foot Qichang Mei1,2,3, Yaodong Gu1,2,3, Vickie Shim1, Justin Fernandez1,2,4
1Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand. 2Research Academy of Grand Health Interdisciplinary, Ningbo University, Ningbo, China. 3Faculty of Sport Science, Ningbo University, Ningbo, China. 4Department of Engineering Science, University of Auckland, Auckland, New Zealand.
O0045 Virtual Preclinical Evaluation of Cementless Femoral Stems for Robustness to Patient and Surgical Variation Rami M A Al-Dirini1, Saulo Martelli1, Dermot O'Rourke1, Daniel Huff2, Mark Taylor1
1College of Science and Engineering, Flinders University of South Australia, Adelaide, Australia. 2DePuy Synthes, Warsaw, USA.
O0046 Machine learning surrogate model for predicting hip fracture from 2D X-ray Dharshini Sreenivasan1, Wilson Fok1, Justin Fernandez1, Ju Zhang2,1
1Auckland Bioengineering Institute, Auckland, New Zealand. 2Formus Labs Ltd, Auckland, New Zealand.
O0048 The Morphology of the Human Mandible: A Computational Modelling Study Ravin Vallabh1, Ju Zhang2, Justin Fernandez2, George Dimitroulis3, David Ackland1
1University of Melbourne, Parkville, Australia. 2Auckland University, Auckland, New Zealand. 3St Vincent's Hospital, Melbourne, Australia.
O0049 Relating parametric prosthetic socket design to the biomechanical response of a transtibial residual limb by surrogate modelling Joshua Steer1, Peter Worsley2, Martin Browne1, Alex Dickinson1
1Bioengineering Research Group, University of Southampton, Southampton, United Kingdom. 2Fundamental Care and Safety Research Group, University of Southampton, Southampton, United Kingdom.
O0052 Validation of a subject-specific musculo-skeletal model of the ankle joint complex Sorin Siegler1, Vishnuvardhan Balakrishnan1, Yusuf Dikici1, Claudio Belvedere2, Paolo Caravaggi2, Alberto Leardini2
1Drexel University, Philadelphia, USA. 2Rizzoli Orthopaedic Institute, Bologna, Italy.
O0054 Effect of corrective surgery on lower limb mechanics in patients with crouch gait Adelle Milholland1, Erika Ramirez1, Jason Rhodes2, Alex Tagawa2, Clare Fitzpatrick1
1Boise State University, Boise, USA. 2Children's Hospital Colorado, Denver, USA.
O0055 Development and validation of subject-specific paediatric rigid multibody knee kinematic models with ligamentous constraints Martina Barzan1, David Lloyd1, Luca Modenese1,2, Christopher Carty1,3, Sheanna Maine3, Simao Brito da Luz1
1School of Allied Health Sciences and Gold Coast Orthopaedic Research and Education Alliance, Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia. 2Department of Civil and Environmental Engineering, Imperial College London, London, United Kingdom. 3Children’s Health Queensland Hospital and Health Service, Brisbane, Australia.
O0057 Tendon enthesis development and regeneration Suphanee Pongkitwitoon1, Andrea Schwartz2, Stavros Thomopoulos1
1Columbia University, New York, USA. 2Washington University, St. Louis, USA.
O0058 Role of Estrogen Signaling in Skeletal Mechanobiology Marjolein van der Meulen1,2, Amanda Rooney1, Natalie Kelly3
1Cornell University, Ithaca, USA. 2Hospital for Special Surgery, New York, USA. 3Washington University, St Louis, USA.
O0060 Effects of Reproduction and Lactation on Maternal Bone Mechano-Sensitivity Yihan Li1, Chantal de Bakker1, Wei-Ju Tseng1, Hongbo Zhao1, Ashutosh Parajuli2, Liyun Wang2, X. Sherry Liu1
1University of Pennsylvania, Philadelphia, USA. 2University of Delaware, Newark, USA.
O0061 Age at onset of walking in infancy is associated with hip and spine shape in early old age Alex Ireland1, Stella Muthuri2, Fiona Saunders3, Anastasia Pavlova3, Rebecca Hardy2, Kathryn Martin3, Rebecca Barr3,4, Judith Adams5, Diana Kuh2, Richard Aspden3, Jennifer Gregory3, Rachel Cooper2
1Manchester Metropolitan University, Manchester, United Kingdom. 2University College London, London, United Kingdom. 3University of Aberdeen, Aberdeen, United Kingdom. 4University of Dundee, Dundee, United Kingdom. 5Manchester Royal Infirmary, Manchester, United Kingdom.
O0063 A model to study the role of the vasculature and vascular-specific mediators with ageing for degenerative bone diseases Juan A Núñez1,2, Alice Goring1, Behzad Javaheri3, Diego Gomez-Nicola1, Andrew A Pitsillides3, Philipp J Thurner2,4, Philipp Schneider2, Claire Clarkin1
1Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, United Kingdom. 2Bioengineering Sciences Research Group, Faculty of Engineering and the Environment, University of Southampton, Southampton, United Kingdom. 3Department of Comparative Biomedical Sciences, Royal Veterinary College, London, United Kingdom. 4Institute of Lightweight Design and Structural Biomechanics, Vienna University of Technology, Vienna, Austria.
O0064 Coordinated oscillations of confined epithelial tissues. Joseph d'Alessandro1, Grégoire Peyret1, Romain Mueller2, Begnaud Simon1, Amin Doostmohammadi2, Julia Yeomans2, Benoît Ladoux1
1Institut Jacques Monod, Université Paris Diderot et CNRS UMR7592, Paris, France. 2The Rudolf Peierls Centre for Theoretical Physics, University of Oxford, Oxford, United Kingdom.
O0067 Collective cell migration: intercellular forces coordination by integrin α5β1 Jacopo Di Russo1, Jennifer Young1, Horst Kessler2, Joachim Spatz1
1Max Planck Institute for Medical Research, Heidelberg, Germany. 2Department Chemie, Institute for Advanced Study and Center of Integrated Protein Science Munich (CIPSM) Technical University of Munich, Munich, Germany.
O0070 Investigation of the mechanics of the cell membrane for insertion into a living cell during tip-cell interactions Na Fan1, Bei Peng1, Guixue Wang2
1School of Mechatronics Engineering, University of Electronic Science and Technology of China, Chengdu, China. 2Key Laboratory of Biorheological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China.
O0074 Title: Biologically-inspired heart valve leaflets with outstanding anisotropic and native tissue-like mechanical properties by melt electrospinning writing Navid Toosi Saidy1, Frederic Wolf2, Petra Mela2, Dietmar W. Hutmacher1, Elena M. De-Juan-Pardo1
1Centre in Regenerative Medicine, Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology (QUT), Brisbane, Australia. 2Institute of Applied Medical Engineering, Helmholtz Institute, Aachen, Germany.
O0076 A pulmonary heart valve engineered from natural biomaterials Claire Brougham1,2, Ricardo Moreira3, Tanya Levingstone2,4, Tom Flanagan5, Stefan Jockenhoevel3, Petra Mela3, Fergal O'Brien2,6,7
1Dublin Institute of Technology, Dublin, Ireland. 2Royal College of Surgeons in Ireland, Dublin, Ireland. 3RWTH Aachen, Aachen, Germany. 4Dublin City University, Dublin, Ireland. 5University College Dublin, Dublin, Ireland. 6Trinity College Dublin, Dublin, Ireland. 7AMBER, Dublin, Ireland.
O0077 Scaffold Microstructure dictates Macrophage-driven Biomaterial Degradation – Implications for in situ Cardiovascular Tissue Engineering Tamar Wissing1,2, Valentina Bonito1,2, Carlijn Bouten1,2, Anthal Smits1,2
1Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands. 2Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.
O0078 Integration of statistical shape models of the knee with finite element simulations Clare Fitzpatrick1, Oliver Alvarez1, Kalin Gibbons1, Peter Laz2, Paul Rullkoetter2
1Boise State University, Boise, USA. 2University of Denver, Denver, USA.
O0079 Entering the statistical domain: Do we understand the risk and liabilities of using Deformable Statistical Shapes in biomechanics? Bhushan Borotikar1,2,3, Tinashe Mutsvangwa4
1Laboratoire de Traitement de l’Information Médicale (LaTIM), INSERM U1101, Brest, France. 2CHRU de Brest, Brest, France. 3Département Image et traitement de l'information, IMT Atlantique, Brest, France. 4Department of Biomedical Engineering, University of Cape Town, Cape Town, South Africa.
O0080 The Effect of Scapula Shape on Function of the Rotator Cuff Muscles Erin C.S. Lee1, Neil T. Roach2, Allison Clouthier1, Ryan Bicknell1, Michael J. Bey3, Nathan M. Young4, Michael J. Rainbow1
1Queen's University, Kingston, Canada. 2Harvard University, Cambridge, USA. 3Henry Ford Hospital, Detroit, USA. 4University of California San Francisco, San Francisco, USA.
O0081 Right-to-left shape differences in the radius. Desney Greybe1, Michael Boland1,2, Ju Zhang1,3, Thor Besier1, Kumar Mithraratne1
1Auckland Bioengineering Institute, Auckland, New Zealand. 2Hand Institute, Auckland, New Zealand. 3Formus Labs Ltd, Auckland, New Zealand.
O0084 Homogenization and model reduction of a numerical liver model for real-time application : validation on free-breathing Michael Kugler1, Nathan Lauzeral2, Domenico Borzacchiello2, Majid Baniassadi3, Yannick Hoarau1, Francisco Chinesta4, Alexandre Hostettler5, Luc Soler5, Yves Rémond1, Daniel George1
1Laboratoire ICube, 2 rue Boussingault, Université de Strasbourg, CNRS, 67000 Strasbourg, France. 2High Performance Computing Institute (ICI), Ecole Centrale de Nantes, 44300 Nantes, France. 3School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran 11155-4563, Iran, Islamic Republic of. 4PIMM, ENSAM ParisTech, 151 Boulevard de l’hôpital, 75013 Paris, France. 5Institut de Recherche contre les Cancers de l’Appareil Digestif (IRCAD), 1 Place de l’Hôpital, 67000 Strasbourg, France.
O0085 Assessing the Tensional State of Fibronectin Fibers at the Organ Level: Healthy Tissues versus Tumor Stroma Viola Vogel1, Simon Arnoldini1, Alessandra Moscaroli2, Mamta Chabria1, M. Hilbert2, Samuel Hertig1, Roger Schibli2, Martin Behe2
1ETH Zurich, Zurich, Switzerland. 2PSI, Villigen, Switzerland.
O0086 Imaging inhomogeneous mechanical properties with MR Elastography Matthew McGarry1, Elijah Van Houten2, John Weaver1,3, Keith Paulsen1,3
1Dartmouth College, Hanover, NH, USA. 2University of Sherbrooke, Sherbrooke, QC, Canada. 3Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
O0088 Mapping Neural Circuitry and Brain Activity at High Speed (10Hz) using functional Magnetic Resonance Elastography (fMRE) Samuel Patz1, Daniel Fovargue2, Katharina Schregel3, Navid Nazari4, Ralph Sinkus2
1Department of Radiology, Brigham and Women’s Hospital, Boston, USA. 2Division of Imaging Sciences and Biomedical Engineering, Kings College London, London, United Kingdom. 3Institute of Neuroradiology, University Medical Center Goettingen, Goettingen, Germany. 4Department of Biomedical Engineering, Boston University, Boston, USA.
O0089 Contributions of shear and tensile anisotropy to mechanical properties of the porcine brain estimated by MR elastography Charlotte A. Guertler1, Ruth J. Okamoto1, Curtis L. Johnson2, Philip V. Bayly1,3
1Department of Mechanical Engineering and Materials Science, Washington University, St. Louis, Missouri, USA. 2Department of Biomedical Engineering, University of Delaware, Newark, Delaware, USA. 3Department of Biomedical Engineering, Washington University, St. Louis, Missouri, USA.
O0090 Combining MR elastography with large static deformations to measure nonlinear mechanical properties in vivo: A study in skeletal muscle Kristy Tan1,2, Lauriane Juge1,2, Shaokoon Cheng3, Lynne Bilston1,2
1Neuroscience Research Australia, Randwick, Australia. 2UNSW Medicine, Randwick, Australia. 3Macquarie University, Sydney, Australia.
O0091 Geometrical and mechanical remodeling of the myocardium after Leukemia treatment from CMR. Delphine Perie1, Marianna Gamba1, Marilou Trempe1, Jenny Wang2, Alistair Young2, Martyn Nash2, Daniel Curnier3
1Polytechnique Montreal, Montreal, Canada. 2University of Auckland, Auckland, New Zealand. 3University of Montreal, Montreal, Canada.
O0095 Poroviscoelasticity of neutral and polyelectrolyte hydrogels Yin Chang, Michelle Oyen
Cambridge University Engineering Dept, The Nanoscience Centre, Cambridge, United Kingdom.
O0096 Collagen fibril mechanics under simulated enzymatic degradation: a molecular dynamics study David Cesar Malaspina1, Yasin Dhaher2,3
1ICMAB-CSIC, Barcelona, Spain. 2Northwestern University, Chicago, USA. 3IRC, Chicago, USA.
O0098 Molecular Mechanisms of Force Transmission Across the Nuclear Envelope Zeinab Jahed1, Mohammad Mofrad2
1University of California Berkeley, Berkeley, USA. 2University of California, Berkeley, USA.
O0102 Savio L-Y. Woo Medal Kyriacos A. Athanasiou
University of California, Irvine, California, USA.
O0103 Robert M. Nerem Medal Roger D. Kamm
Massachusetts Institute of Technology, MA, USA.
O0104 H.R. Lissner Medal Louis J. Soslowsky
Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
O0107 Why does capillary haematocrit decrease to 15 % in a vasocontricted microvascular bed ? Jacques Huyghe,
Bernal Institute, University of Limerick, Limerick, Ireland. Eindhoven University of Technology, Department of Mechanical Engineering, Eindhoven, Netherlands.
O0109 The In Vivo Stress State of Human Cardiovascular Tissue Mathias Peirlinck1, Matthieu De Beule1,2, Patrick Segers1, Nuno Rebelo3
1Biofluid, Tissue and Solid Mechanics for Medical Applications Lab (IBiTech, bioMMeda) - Ghent University, Gent, Belgium. 2FEops nv, Gent, Belgium. 3Dassault Systèmes Simulia Corporation, Santa Clara, USA.
O0110 Automatic tuning of a cardiovascular simulator into patient-specific condition Libera Fresiello1, Gianfranco Ferrari2, Steven Jacobs1, Bart Meyns1
1Department of Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium. 2Nalecz Insitute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland.
O0113 Mechanical characterisation of brain tissue at 1, 10, and 100/s using a custom-built micro-indentation apparatus David MacManus1, Jeremiah Murphy2, Michael Gilchrist1
1University College Dublin, Dublin, Ireland. 2Dublin City University, Dublin, Ireland.
O0114 The Impact of the Arterial Network on Brain Response Under Inertial Loading Fatma Madouh, Kaliat Ramesh, Jeffrey Glaister, Jerry Prince
The Johns Hopkins University, Baltimore, USA.
O0115 The Peculiar Role of Sutures in Infant Head Impact Biomechanics Xiaogai Li, Svein Kleiven
Division of Neuronic Engineering, Royal Institute of Technology (KTH), Stockholm, Sweden.
O0116 Interrupted high-rate compression of porcine brain tissue Lakiesha Williams1, Haden Johnson1, Wilburn Whittington1, Michael Jones2, Alicia Olivier1, Raj Prabhu1
1Mississippi State Univ., Mississippi State, USA. 2Cardiff University, Cardiff, United Kingdom.
O0117 Effect of brain morphometry on impact-induced local strain fields Ashley Mazurkiewicz1, Stephane Magnan1, Rohan Banton2, Thuvan Piehler3, Hanspeter Frei1, Oren E. Petel1
1Carleton University, Ottawa, Canada. 2U.S. Army Research Laboratory, Aberdeen Proving Ground, Adelphi, USA. 3U.S. Army Medical Research and Material Command, Fort Detrick, USA.
O0118 Effect of Heterogeneity of White Matter Structures on Stress Wave Propagation during Blunt Head Trauma Martin Ostoja-Starzewski, Amit Madhukar
Department of Mechanical Science and Engineering, University of Illinois Urbana-Champaign, Champaign, USA.
O0119 Regional mechanical properties of cortical meninges: the protective role of the meninges in concussive impacts Darragh Walsh1,2, Kieran McGourty1,2, Shreyas Mulay2, Aisling Ross1,2, David Newport1,2, John Mulvihill1,2
1Bernal Institute, Co. Limerick, Ireland. 2School of Science and Engineering, University of Limerick, Co. Limerick, Ireland.
O0120 Finite element strain based measures do not correlate with kinematic risk based measures of head impact exposure Logan Miller1, Jillian Urban2, Joel Stitzel2
1Wake Forest University, Winston Salem, USA. 2Wake Forest University School of Medicine, Winston Salem, USA.
O0122 Multiscale and multiaxial mechanics of vascular smooth muscle contractility Sae-Il Murtada1, Jay Humphrey1, Gerhard Holzapfel2,3
1Yale University, New Haven, USA. 2Graz University of Technology, Graz, Austria. 3Norwegian University of Science and Technology, Trondheim, Norway.
O0123 On a three-dimensional mechano-electrochemical model for smooth muscle contraction Robert Seydewitz1, Enrique Morales1, Tobias Siebert2, Markus Böl1
1Institute of Solid Mechanics, Braunschweig, Germany. 2Institute of Sport and Motion Science, Stuttgart, Germany.
O0125 Finite element implementation of growth induced three-dimensional residual stress in the aortic wall Haofei Liu1, Ming Zhang1, Minliang Liu2, Caitlin Martin2, Wei Sun2
1Tianjin University, Tianjin, China. 2Georgia Institute of Technology, Atlanta, USA.
O0126 Determination of In-Vivo Mechanical Properties in Lower Extremity Arteries Rossella Colli1, Francesco Migliavacca1, Scott Berceli2, Jose F Rodriguez Matas1
1Politecnico di Milano, Milano, Italy. 2University of Florida, Gainesville, USA.
O0127 Machine-learning investigation of relationship between strength and response features in ascending thoracic aneurysm tissue Yuanming Luo1, Zhiwei Fan2, Stephen Baek1, Jia Lu1
1The University of Iowa, Iowa City, IA, USA. 2University of Wisconsin-Madison, Madison, WI, USA.
O0129 Eye Injury Risk and Modeling, Past Present and Future Joel Stitzel1, Ashley Weaver1, Kyle McNamara1, Andrew Kemper2, Eric Kennedy3, Stefan Duma2
1Wake Forest University, Winston-Salem, USA. 2Virginia Tech, Blacksburg, USA. 3Bucknell, Lewisburg, USA.
O0131 Bursa premacularis: a numerical simulation of saccadic movements to get insight on its functional role. Maria Grazia Badas1, Tommaso Rossi2, Giorgio Querzoli1, Laura Landi2, Michele Brun1, Daniel Meloni1
1DICAAR - University of Cagliari, Cagliari, Italy. 2San Martino Hospital, Genoa, Italy.
O0133 Numerical Study of Wall Shear Stress on Choroidal Endothelium Huidan (Whitney) Yu1,2, Senyou An3, Jun Yao3, Bradley Gelfand4
1Indiana University-Purdue University, Indianapolis (IUPUI), INDIANAPOLIS, USA. 2Indiana University School of Medicine, INDIANAPOLIS, USA. 3China University of Petroleum, Qingdao, China. 4University of Virginia, Charlottesville, USA.
O0138 Alternative muscle recruitment strategies have potential to increase accuracy of joint reaction force estimations in musculoskeletal models Bart van Veen, Luca Modenese, Claudia Mazzà, Marco Viceconti
INSIGNEO Institute for in silico Medicine, Department of Mechanical Engineering, University of Sheffield, Sheffield, United Kingdom.
O0140 Implementation of a subject-specific paediatric kinematic model of the knee with minimally deformable ligaments in OpenSim Martina Barzan1, David Lloyd1, Nicola Sancisi2, Simao Brito da Luz1, Christopher Carty1,3, Sheanna Maine3, Luca Modenese4,1
1School of Allied Health Sciences and Gold Coast Orthopaedic Research and Education Alliance, Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia. 2Department of Industrial Engineering, CIRI Health Sciences and Technologies, University of Bologna, Bologna, Italy. 3Children’s Health Queensland Hospital and Health Service, Brisbane, Australia. 4Department of Civil and Environmental Engineering, Imperial College London, London, United Kingdom.
O0147 Cryosurgery and electrolysis - Cryoelectrolysis Franco Lugnani1,2, Boris Rubinsky3
1Hippocrates DOO,, Divaca, Slovenia. 2Clinica Santa Elena, Malaga, Spain. 3University of California Berkeley, Berkeley, USA.
O0149 Towards a simulation-based understanding of musculoskeletal deformity and their therapeutic remediation in children with cerebral palsy. Ilse Jonkers1, Hans Kains2, Lorenzo Pitto2, Antoine Mottet Dit Falisse2, Tessa Hoekstra2, Mariska Wesseling2, Guy Molenaerts2,3, Anja Van Campenhout3, Kaat Desloovere2,3, Friedl De Groote2
1Ku Leuven, Leuven, Belgium. 2KU Leuven, Leuven, Belgium. 3UZ Leuven, Leuven, Belgium.
O0151 Validation of non-invasive treatments for temporomandibular joint disorders during childhood considering the porous-fibrous properties of the joint J. Ortún-Terrazas1, J. Cegoñino1, U. Santana-Penín2, U. Santana-Mora2, A. Pérez del Palomar1
1Group of Biomaterials, Aragon Institute of Engineering Research (I3A), Zaragoza, Spain. 2Faculty of Medicine and Odontology, Santiago de Compostela University, Santiago de Compostela, Spain.
O0152 Development of Personalised Infant Femur Finite Element Models Combining Paired CT and MRI Examinations A. P. G. Castro1,2, Z. Altai1, A. C. Offiah3, S. C. Shelmerdine4,5, O. J. Arthurs4,5, X. Li1, D. Lacroix1
1INSIGNEO Institute for in silico Medicine, Dept. Mechanical Engineering, The University of Sheffield, Sheffield, United Kingdom. 2IDMEC, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal. 3Dept. of Oncology and Human Metabolism, University of Sheffield, Sheffield, United Kingdom. 4Dept. of Radiology, Great Ormond Street Hospital for Children, London, United Kingdom. 5UCL Great Ormond Street Institute for Child Health, University College London, London, United Kingdom.
O0153 How can load directions due to different physical activities affect proximal femoral growth? Priti Yadav1,2, Lanie Gutierrez Farewik1,2,3
1KTH Mechanics, Royal Institute of Technology, Stockholm, Sweden. 2KTH BioMEx Center, Stockholm, Sweden. 3Dept. of Women’s & Children’s Health, Karolinska Institutet,, Stockholm, Sweden.
O0154 Acute Effects of Botulinum Toxin Within and Beyond Injected Rat Triceps Surae Muscles Contradict Some of the Treatment Objectives Filiz Ates1, Orkun Akcan2, Can A. Yucesoy2
1Motion Analysis Laboratory, Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. 2Institute of Biomedical Engineering, Boğaziçi University, Istanbul, Turkey.
O0155 Comparisons of Gait Patterns Between Children With and Without Avascular Necrosis After Osteotomy for Developmental Dysplasia of the Hip Tsan-Yang Chen1, Wei-Chun Lee2,1, Yang-Chieh Fu3, Yu-Lin Tsai4, Hsiang-Ho Chen4, Tung-Wu Lu1,5
1Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan. 2Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan. 3Institute of Biomedical Engineering, National Taiwan University,, Taipei, Taiwan. 4Department of Graduate Institute of Nanomedicine and Medical Engineering, Taipei Medical University, Taipei, Taiwan. 5Department of Orthopaedic Surgery, School of Medicine, National Taiwan University, Taipei, Taiwan.
O0156 EMG-Driven Fibril Reinforced Poroviscoelastic Finite Element Model of the Knee Joint Amir Esrafilian, Lauri Stenroth, Mika Mononen, Petri Tanska, Paavo Vartiainen, Rami Korhonen
University of Eastern Finland, Kuopio, Finland.
O0158 Musculoskeletal multibody simulation to predict functional outcome of different total knee replacement designs during dynamic activities Maeruan Kebbach1, Andreas Geier1, Martin Darowski1, Sven Krueger2, Christoph Schilling2, Thomas Grupp2,3, Rainer Bader1
1Department of Orthopaedics, University Medicine Rostock, Rostock, Germany. 2Aesculap AG Research & Development, Tuttlingen, Germany. 3Ludwig Maximilians University Munich, Department of Orthopaedic Surgery, Physical Medicine & Rehabilitation, Campus Grosshadern Munich, Germany.
O0159 The Role of the Anterior Cruciate Ligament in Rotational Laxity Varies from Knee-to-Knee Carl Imhauser1, Mohammad Kia1, Po-Hsu Chen2, Jonathan Race2, Andrew Pearle1, Thomas Wickiewicz2, Thomas Santner2
1Hospital for Special Surgery, New York, USA. 2The Ohio State University, Columbus, USA.
O0160 Segment Contributions to Medial Longitudinal Arch Recoil During Propulsion Ashton J. Stoop1, Lauren Welte1, Luke Kelly2, Toni Arndt3, Michael J. Rainbow1
1Queen's University, Kingston, Canada. 2The University of Queensland, Brisbane, Australia. 3The Swedish School of Sport and Health Sciences (GIH), Stockholm, Sweden.
O0161 Effect of Combined Version on Sit-to-Stand Kinematics in Total Hip Replacement: A Computational Analysis Brandon Marine1, Jennifer Wayne1, Niraj Kalore2
1Virginia Commonwealth University, Department of Biomedical Engineering, Richmond, USA. 2Virginia Commonwealth University, Department of Orthopaedic Surgery, Richmond, USA.
O0162 Effects of loosened posteromedial meniscal root repairs on knee mechanics Brett Steineman1, Robert LaPrade2, Joseph Clouse1, Tammy Haut Donahue1
1Colorado State University, Fort Collins, CO, USA. 2Steadman Philippon Research Institute, Vail, CO, USA.
O0163 Effect of trochlear dysplasia on patellar tracking and patellofemoral contact pressure. A musculoskeletal analysis using an efficient cartilage contact model. Marco Marra1,2, Antonino Bisognano3, Sebastiaan van de Groes1, Dennis Janssen1, Bart Koopman2, Nico Verdonschot1,2
1Radboud University Medical Center, Nijmegen, Netherlands. 2University of Twente, Enschede, Netherlands. 3Politecnico di Milano, Milan, Italy.
O0164 Surrogate-based optimization of acetabular implant design through minimization of stress shielding Fernando Perez Boerema1, Pawel Tomaszewski2, Semih Perdahcıoğlu3, Dennis Janssen2, Liesbet Geris1, Nico Verdonschot2
1KU Leuven, Leuven, Belgium. 2Radboudumc, Nijmegen, Netherlands. 3University of Twente, Enschede, Netherlands.
O0165 Growth map of the prenatal mouse knee joint measured by deformable registration Mario Giorgi1,2, Vivien Sotiriou3, Niccolò Fanchini4, Simone Conigliaro4, Cristina Bignardi4, Niamh C. Nowlan3, Enrico Dall'Ara1,2
1The University of Sheffield, Sheffield, United Kingdom. 2Insigneo institute for in silico medicine, Sheffield, United Kingdom. 3Imperial College London, London, United Kingdom. 4Politecnico di Torino, Turin, Italy.
O0166 Modeling spatiotemporal activities of bone cells regulated by transforming growth factor-β Young Kwan Kim1,2, Yoshitaka Kameo2, Sakae Tanaka1, Taiji Adachi2
1Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan. 2Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.
O0168 Biomechanical analysis of paediatric long bone growth modulation treatment by patient-specific finite element modelling Peter Varga1, Manuel Schneider1, Jan Buschbaum1, Alexander Joeris2, Oliver Röhrle3, Jonathan Dwyer4, Theodor Slongo5, Boyko Gueorguiev1
1AO Research Institute Davos, Davos, Switzerland. 2AO Clinical Investigation and Documentation, Davos, Switzerland. 3University of Stuttgart, Stuttgart, Germany. 4University Hospital of North Staffordshire, Staffordshire, United Kingdom. 5University Children's Hospital, Bern, Switzerland.
O0169 Tibia cross-sectional roundness is related to ambulation, but not age, in children with myelomeningocele Kyle P. Chadwick1, Nicole M. Mueske1, Rachel E. Horenstein2, Sandra J. Shefelbine2, Tishya A. Wren1,3
1Children's Hospital Los Angeles, Los Angeles, CA, USA. 2Northeastern University, Boston, MA, USA. 3University of Southern California, Los Angeles, CA, USA.
O0170 Fibroblast Growth Factor 9 (FGF9) regulates postnatal skeletal movement and muscle loading Megan Killian1, Elahe Ganji1, Keira Morgan2, Emily Hudson1
1University of Delaware, Newark, USA. 2Newark Charter School, Newark, USA.
O0171 Obesity and short-term aerobic exercise effects on bone microscale material properties are sex-specific Vanessa Sherk1, Chelsea Heveran2, Rebecca Foright1, Ginger Johnson1, Virginia Ferguson2, Paul MacLean1
1University of Colorado Anschutz Medical Campus, Aurora, USA. 2University of Colorado Boulder, Boulder, USA.
O0172 Understanding muscle-bone cellular crosstalk in aging Jonathan Doering1,2, Carly Britt1,2, Jacqueline Cole1,2
1North Carolina State University, Raleigh, USA. 2University of North Carolina at Chapel Hill, Chapel Hill, USA.
O0173 Sciatic neurectomy increases bone mechanosensitivity in mature and old mice Judith Piet1, Dorothy Hu2, Roland Baron2, Sandra Shefelbine1
1Northeastern University, Boston, USA. 2Harvard School of Dental Medicine, Boston, USA.
O0174 Geometrical constraints during epithelial jamming Lior Atia1, Dapeng Bi2, Yasha Sharma1, Jennifer A. Mitchel1, Bomi Gweon1,3, Stephan Koehler1, Stephen J. DeCamp1, Bo Lan1, Jae Hun Kim1, Rebecca Hirsch1, Adrian F. Pegoraro4, Kyu Ha Lee5, Jacqueline Starr5, David A. Weitz4, Adam C. Martin6, Jin-Ah Park1, James P. Butler1,7, Jeffery J. Fredberg1
1Harvard T.H. Chan School of Public Health, Boston, USA. 2Northeastern University, Boston, USA. 3Hanyang University, Seoul, Korea, Republic of. 4Harvard University, Cambridge, USA. 5The Forsyth Institute, Cambridge, USA. 6Massachusetts Institute of Technology, Cambridge, USA. 7Brigham and Women's Hospital and Medical School, Boston, USA.
O0175 Asymmetry in the flagellar waveform of a swimming alga increases propulsive power Mathieu Bottier1,2, Susan K. Dutcher2, Philip V. Bayly1
1Department of Mechanical Engineering and Materials Science, Washington University in Saint Louis, Saint Louis, MO, USA. 2Department of Genetics, Washington University in Saint Louis, Saint Louis, MO, USA.
O0176 Stochastic Dynamics of Cell Migration in Complex Environments David B. Brückner1, Alexandra Fink2, Christoph Schreiber2, Peter J. F. Röttgermann2, Joachim O. Rädler2, Chase P. Broedersz1
1Arnold-Sommerfeld-Center for Theoretical Physics and Center for NanoScience, Ludwig-Maximilians-Universität, Munich, Germany. 2Faculty of Physics and Center for NanoScience, Ludwig-Maximilians-Universität, Munich, Germany.
O0177 Stress decomposition in the expanding epithelial monolayer Youngbin Cho1, Bomi Gweon2, Jacob Notbohm3, Dayoung Kim1, Hyuntae Jeong1, Hwanseok Jang4, David Helfman1, Yongdoo Park4, Jeffrey Fredberg5, Jennifer Shin1
1Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of. 2Hanyang University, Seoul, Korea, Republic of. 3University of Wisconsin-Madison, Madison, USA. 4Korea University, Seoul, Korea, Republic of. 5Harvard T.H. Chan School of Public Health, Boston, USA.
O0178 Substrate adhesive area confinement is a key determinant of cell velocity in collective migration Danahe Mohammed1, Guillaume Charras2, Marie Versaevel1, Joséphine Lantoine1, Laura Alaimo1, Céline Bruyère1, Marine Luciano1, Karine Glinel3, Sylvain Gabriele1
1Umons, Mons, Belgium. 2London Centre for Nanotechnology, University College London, London, United Kingdom. 3UCL, Louvain, Belgium.
O0179 Polarity Dynamics of Epithelial Trains During Inititaion And Maintenance of Directed Collective Cell Migration Shreyansh Jain1, Victoire M. L. Cachoux2, Tianchi Chen1, Melina Heuze3, Rene-Marc Mege3, Alexandre Kabla2, Chwee Teck Lim4,1, Benoit Ladoux3
1Mechanobiology Institute, NUS, Singapore, Singapore. 2Engineering Department, University of Cambridge, cambridge, United Kingdom. 3Institut Jacques Monod (IJM) ,Université Paris Diderot, Paris, France. 4Division of Bioengineering, Department of Mechanical Engineering, National University of Singapore, Singapore, Singapore.
O0180 The unjamming transition is distinct from the epithelial-to-mesenchymal transition Jennifer Mitchel1, Michael O'Sullivan1, Amit Das2, Angela Nieto3, Dapeng Bi2, James Butler1, Jeffrey Fredberg1, Jin-Ah Park1
1Harvard T.H. Chan School of Public Health, Boston, USA. 2Northeastern University, Boston, USA. 3Instituto de Neurociencias, Alicante, Spain.
O0181 Cell Migration Behaviour Modulated by Extracellular Matrix Environment Toshiro Ohashi, Mazlee Bin Mazalan, Akito Sugawara, Yasufumi Hagiwara
Hokkaido University, Sapporo, Japan.
O0183 Computational model-driven design of tissue engineered vascular grafts Jay Humphrey1, Ramak Khosravi1, Jason Szafron1, Kristin Miller2
1Yale University, New Haven, USA. 2Tulane University, New Orleans, USA.
O0185 Emergence of a geometrical and mechanical equilibrium in engineered cardiovascular tissues Pim Oomen, Mathieu van Kelle, Marloes Janssen - van den Broek, Richard Lopata, Sandra Loerakker, Carlijn Bouten
Eindhoven University of Technology, Eindhoven, Netherlands.
O0187 Compressive loading regulates microvascular growth in vitro Marissa Ruehle1,2, Laxminarayanan Krishnan1, Ryan Akman1,2, Steven LaBelle3, Nick Willett2,1, Jeffrey Weiss3, Robert Guldberg1
1Georgia Institute of Technology, Atlanta, USA. 2Emory University, Atlanta, USA. 3University of Utah, Salt Lake City, USA.
O0188 The Combined Effect Of Shear Stress And Cyclic Strain On (Myo)Fibroblast/Monocyte-Induced Matrix Growth And Remodeling In A 3D Vascular Scaffold Eline E. van Haaften1,2, Tamar B. Wissing1,2, Anthal I.P.M. Smits1,2, Nicholas A. Kurniawan1,2, Carlijn V.C. Bouten1,2
1Soft Tissue Engineering and Mechanobiology, Eindhoven University of Technology, Eindhoven, Netherlands. 2Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.
O0190 Characterization of physiological development of the hip in children using statistical shape models Lorenzo Grassi1, Hannicka Sahlstedt1, Carl-Johan Tiderius2, Magnus Karlsson2, Sami P. Väänänen3,4, Hanna Isaksson1
1Department of Biomedical Engineering, Lund University, Lund, Sweden. 2Department of Orthopaedics, Lund University, Lund, Sweden. 3Department of Applied Physics, University of Eastern Finland, Kuopio, Finland. 4Department of Orthopaedics, Traumatology and Hand Surgery, Kuopio University Hospital, Kuopio, Finland.
O0192 Addressing high dimensionality and low sample size data for mesh-based morphometric analysis: Shoulder form and shape analyses and implications to biomechanics modelling Jean-Rassaire Fouefack1, Adijat Omowumi Inyang1, Tania Douglas1, Bhushan Borotikar2, Valérie Burdin2, Tinashe Mutsvangwa1
1Division of Biomedical Engineering, University of Cape Town, Cape Town, South Africa. 2IMT Atlantique, Brest, France.
O0193 Association of Bony Morphology of the Distal Femur and ACL Injuries Sene Polamalu1,2, William Anderst1,3, Volker Musahl1,2, Richard Debski1,2
1University of Pittsburgh, Pittsburgh, USA. 2Orthopaedic Robotics Laboratory, Pittsburgh, USA. 3Biodynamics Laboratory, Pittsburgh, USA.
O0194 A comparison between osteoarthritic and asymptomatic knees using statistical shape modelling Joe Lynch1,2, Md. Asikuzzaman3, Mark Pickering3,2, Jennie Scarvell4,2, Paul Smith1,2, Thor Besier5, Marco Schneider5
1Australian National University, Canberra, Australia. 2Trauma and Orthopaedic Research Unit, Canberra, Australia. 3University of New South Wales, Canberra, Canberra, Australia. 4University of Canberra, Canberra, Australia. 5Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
O0196 New method of 3D reconstruction of the intra and extra cranial surfaces based on CT-scan data. Pierre-Marc François1, Baptiste Sandoz1, Philippe Decq1,2, Sebastien Laporte1
1Arts et Métiers Paristech, Institut de Biomécanique Humaine Georges Charpak, Paris, France. 2Service de neurochirurgie, Hôpital Beaujon (AP-HP), Clichy, France.
O0197 Effect of age and sex on the pelvis, femur and tibia clinical shape parameters in 157 normal individuals aged 5 to 45 years old Morgan Sangeux1,2,3, Yijun Elgin Leow3, H. Kerr Graham1,2,3
1The Royal Children's Hospital, Melbourne, Australia. 2The Murdoch Children's Research Institute, Melbourne, Australia. 3The University of Melbourne, Melbourne, Australia.
O0198 Diagnosis of TMJ disorders using parametric numerical models obtained by active shape model of orthopantomography J. Ortún-Terrazas1, J. Cegoñino1, U. Santana-Penín2, U. Santana-Mora2, A. Pérez del Palomar1
1Group of Biomaterials, Aragon Institute of Engineering Research (I3A), Zaragoza, Spain. 2Faculty of Medicine and Odontology, Santiago de Compostela University, Santiago de Compostela, Spain.
O0199 An automated computational biomechanics workflow for improving breast cancer diagnosis and treatment Martyn P. Nash, Thiranja P. Babarenda Gamage, Duane T.K. Malcolm, Anthony Doyle, Poul M.F. Nielsen
University of Auckland, Auckland, New Zealand.
O0201 Breast skin strain during everyday activities Michelle Norris, Amy Sanchez, Chris Mills, Joanna Wakefield-Scurr
University of Portsmouth, Portsmouth, United Kingdom.
O0202 Designing experiments for identifying breast tissue mechanical properties Thiranja Babarenda Gamage1, Poul Nielsen1,2, Martyn Nash1,2
1Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand. 2Department of Engineering Science, University of Auckland, Auckland, New Zealand.
O0203 Analysis of breast implants failure as a template for a better manufacturing. Nilza Ramião1, Pedro Martins1, Maria da Luz Barroso2, Diana Costa Santos2, Antonio Augusto Fernandes1
1INEGI - Instituto de Ciência e Inovação em Engenharia Mecânica e Engenharia Industrial, Porto, Portugal. 2Department of Plastic Surgery of Gaia Hospital Center, Vila Nova de Gaia, Portugal.
O0204 Preliminary study on infant applied pressures during breastfeeding and Poisson's ratio in lactating human nipple Diana Alatalo1, Lin Jiang1, Donna Geddes2, Fatemeh Hassanipour1
1The University of Texas at Dallas, Richardson, USA. 2University of Western Australia, Perth, Australia.
O0205 Is breast pain related to breast movement in elite female athletes? Implications for biomechanical research. Brooke Brisbine1,2, Julie Steele1, Elissa Phillips2, Deirdre McGhee1
1University of Wollongong, Wollongong, Australia. 2Australian Institute of Sport, Canberra, Australia.
O0209 Changes in the efficiency of actin cytoskeletal force transmission to cell nucleus during osteogenic differentiation in human mesenchymal stem cell Hiromi Miyoshi1,2, Masashi Yamazaki1,2, Manabu Numao1,2
1Graduate School of System Design,Tokyo Metropolitan University, Tokyo, Japan. 2PRIME, AMED, Tokyo, Japan.
O0212 Tropomyosin heterodimers as a new model for studying the effects of myopathic mutations. Alexander Matyushenko1, Daria Logvinova1,2, Daniil Shchepkin3, Galina Kopylova3, Sergey Bershitsky3, Dmitrii Levitsky1
1A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russian Federation. 22 Department of Biochemistry, School of Biology, Moscow State University, Moscow, Russian Federation. 3Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Yekaterinburg, Russian Federation.
O0214 Changes in the collagen fibre architecture within stented arterial tissue may play a critical role in directing the vascular cell response post stenting C. Lally1, D.R. Nolan1, P.S. Mathieu1, A. McMahon1, P.A. Cahill2, E. Fitzpatrick1
1Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, and School of Engineering, Trinity College Dublin, Dublin, Ireland. 2School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.
O0215 The Distal-to-Proximal Shift of Muscle Function during Walking in Old Age is Absent for Negative Work Jeroen Waanders1,2, Tibor Hortobágyi1,2, Alessio Murgia1,2, Paul DeVita3, Jason Franz4
1University of Groningen, Groningen, Netherlands. 2University Medical Centre Groningen, Groningen, Netherlands. 3East Carolina University, Greenville, USA. 4University of North Carolina and North Carolina State University, Chapel Hill, USA.
O0216 Older adults reverse their distal-to-proximal redistribution with ankle power biofeedback Michael Browne, Jason Franz
University of North Carolina and North Carolina State University, Chapel Hill, NC, USA.
O0217 Older Adults’ Propulsive Reserve Is Larger Than Their Deficit to Young Adults Katie Conway, Randall Bissette, Jason Franz
University of North Carolina and North Carolina State University, Chapel Hill, USA.
O0218 The metabolic cost of transport is not elevated in healthy and aerobically fit elderly compared to young in both overground or treadmill walking Sauvik Das Gupta1,2, Herre Faber1,2, Dinant Kistemaker1,2, Maarten Bobbert1,2
1Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit, Amsterdam, Netherlands. 2Amsterdam Movement Sciences, Amsterdam, Netherlands.
O0219 Effect of walking surface and late-cueing on turn strategy preferences in older adults. Philippe Dixon1,2, Tina Smith3, Matthew Taylor4, Jesse Jacobs2, Jack Dennerlein1,5, Jeffrey Schiffman2
1Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, USA. 2Liberty Mutual Research Institute for Safety, Hopkinton, USA. 3Faculty of Education, Health & Wellbeing, University of Wolverhampton, Walsall, United Kingdom. 4School of Sport, Rehabilitation and Exercise Sciences, University of Essex, Colchester, United Kingdom. 5Bouvé College of Health Sciences, Northeastern University, Boston, USA.
O0220 Do older adults select appropriate motor strategies in a stepping down paradigm? Nick Kluft, Sjoerd Bruijn, Jaap van Dieën, Mirjam Pijnappels
Amsterdam Movement Sciences, Amsterdam, Netherlands.
O0221 Differences in stair descent biomechanics between older fallers, older non-fallers and younger individuals. Thijs Ackermans, Natasha Francksen, Carolyn Lees, Paulo Lisboa, Mark Hollands, Thomas O'Brien, Constantinos Maganaris
Liverpool John Moores University, Liverpool, United Kingdom.
O0222 Ability to discriminate Fallers from Non-Fallers with the Clinical Test of Sensory Interaction and Balance implemented with different technologies and metrics Jeremy Angus1, Drew Commandeur1, Marc Klimstra1,2, Sandra Hundza1
1University of Victoria, Victoria, Canada. 2Canadian Sports Institute-Pacific, Victoria, Canada.
O0223 Biomechanical Research on Dual-Task Walking to Evaluate Risk Factors of Falls in the Elderly. Wooseong Heo, Hye-ree Kim, Min-ra Choi, Jae-myung Kim, Ki-Kwang Lee, Min-young Shin, Sung-jun Kim
Kookmin University, seoul, Korea, Republic of.
O0225 Discovering the relationship between NF-κB and shear stress in cardiovascular disease DC Baeriswyl1, I Prionisti1, G Tsolkas2, T Peach1, JC Vardakis1, S Morel3, P Bijlenga4, B Kwak3, R Krams2, Y Ventikos1
1Department of Mechanical Engineering, University College London, London, United Kingdom. 2Department of Bioengineering, Imperial College London, London, United Kingdom. 3Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland. 4Geneva Neuroscience Centre, University of Geneva, Geneva, Switzerland.
O0226 Temporal and spatial changes in wall shear stress during atherosclerotic plaque progression in mice Ruoyu Xing1, Astrid Moerman2, Yanto Ridwan3, Mat Daemen4, Anton van der Steen2, Frank Gijsen2, Kim van der Heiden2
1Erasmus MC, Rotterdam, Netherlands. 2Department of Biomedical Engineering, Erasmus MC, Rotterdam, Netherlands. 3Department of Molecular Genetics, Erasmus MC, Rotterdam, Netherlands. 4Department of Pathology, AMC, Amsterdam, Netherlands.
O0227 Cyclic Strain affects Macrophage Polarization and Cytokine Secretion in a 3D Scaffold Microenvironment - Implications for In Situ Cardiovascular Tissue Engineering Valentina Bonito1,2, Bente de Kort1, Carlijn Bouten1,2, Anthal Smits1,2
1Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands. 2Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.
O0232 Posture determines the mechanism of injury in under-vehicle explosions Grigorios Grigoriadis, Diagarajen Carpanen, Claire Webster, Nicolas Newell, Spyros Masouros
Imperial College London, London, United Kingdom.
O0233 Pelvis injury and injury risk curves from simulated underbody blast loading Frank Pintar1,2, Jason Moore1, JiangYue Zhang3, Narayan Yoganandan1,2
1Medical College of Wisconsin, Milwaukee, USA. 2VA Medical Center, Milwaukee, USA. 3Johns Hopkins University Applied Physics Laboratory, Laurel, USA.
O0234 Injury Tolerance for Blast Mediated Bending of the Human Femur E. Meade Spratley1, Kyvory Henderson1, Liming Voo2, Suzanne Bilodeau3, Robert Salzar1
1University of Virginia, Charlottesville, USA. 2Johns Hopkins Applied Physics Laboratory, Laurel, USA. 3Army Research Laboratory, Aberdeen, USA.
O0235 Rate and Posture Effects on the Cervical Spine Stiffness during High Rate Vertical Loading Maria Ortiz-Paparoni1, Brian Bigler1, Courtney Cox1, Allison Schmidt1, Jay Shridharani1, Jason Kait1, Joost Op't Eynde1, Liming Voo2, Cameron "Dale" Bass1
1Duke University, Durham, USA. 2John Hopkins University, Baltimore, USA.
O0236 Injury Risk Assessment for Behind Armor Blunt Trauma Impact Conditions using Thorax Finite Element Model Duane Cronin1, Jeffery Barker1, Karin Rafaels2, Cynthia Bir3
1University of Waterloo, Waterloo, Canada. 2United States Army Research Laboratory, APG, MD, USA. 3University of Southern California, Los Angeles, USA.
O0237 Numerical modeling of rupture in human arterial walls Osman Gültekin1, Hüsnü Dal2, Gerhard Holzapfel1,3
1Institute of Biomechanics, TU Graz, Graz, Austria. 2Mechanical Engineering Department, METU, Ankara, Turkey. 3Faculty of Engineering Science and Technology, NTNU, Trondheim, Norway.
O0239 A constituent specific study of damage accumulation in arterial tissue Milad Ghasemi1,2, David Nolan1,2, Caitríona Lally1,2
1Trinity Centre for Bioengineering, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland. 2Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Dublin, Ireland.
O0240 Fracture behaviour and microstructure-mechanics relationship of human aortic aneurysms Aziz Tokgoz1, Shuo Wang2, Priya Sastry3, Chang Sun2, Nichola Figg3, Martin R. Bennett3, Sanjay Sinha3, Jonathan H. Gillard2, Michael P. F. Sutcliffe1, Zhongzhao Teng2,1
1Department of Engineering, University of Cambridge, Cambridge, United Kingdom. 2Department of Radiology, University of Cambridge, Cambridge, United Kingdom. 3Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
O0241 A One Fiber Family Constitutive Model of the Right Pulmonary Artery Erica Pursell1,2, Daniela Valdez-Jasso1,2
1University of Illinois at Chicago, Chicago, USA. 2University of California San Diego, San Diego, USA.
O0243 Postnatal melatonin treatment improves compliance of conductance arteries in chronic hypoxic lambs Eugenio Rivera1, Claudio Garcia-Herrera1, Daniel Cañas1, Emilio Herrera2
1Universidad de Santiago de Chile, Santiago, Chile. 2Universidad de Chile, Santiago, Chile.
O0244 Changes in the material properties of aorta due to trauma Kurosh Darvish, Ali Hemmasizadeh, Soroush Assari
Temple University Biomechanics Lab, Philadelphia, USA.
O0245 Impact of assumption of affine deformation on constitutive models of arterial tissue Martin Slazansky1, Stanislav Polzer2, Jiri Bursa1
1Institute of Solid Mechanics, Mechatronics and Biomechanics, Faculty of Mechanical Engineering, Brno University of Technology, Brno, Czech Republic. 2Department of Applied Mechanics, Faculty of Mechanical Engineering, VSB – Technical University of Ostrava, Ostrava, Czech Republic.
O0246 Mechanoregulation of Intraocular Pressure by Nitric Oxide Darryl Overby1, Jason Chang1, Joseph Sherwood1, Daniel Stamer2
1Imperial College London, London, United Kingdom. 2Duke University, Durham, USA.
O0247 In Vivo Extraction of the Biomechanical Properties of Human Optic Nerve Head Tissues in Healthy, Ocular Hypertensive, and Glaucoma Eyes using a Custom Virtual Fields Method Michael Girard1,2, Mani Baskaran2, Tin Aung Tun1,2, Nicholas Strouthidis3, Tin Aung2,4, Liang Zhang1
1Ophthalmic Engineering and Innovation Laboratory, Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore. 2Singapore Eye Research Institute, Singapore, Singapore. 3Moorfields Eye Hospital, London, United Kingdom. 4Singapore National Eye Centre, Singapore, Singapore.
O0248 In-situ measurement of intraocular pressure-induced deformation of the capillaries and collagenous beams of the lamina cribrosa Bryn Brazile, Bin Yang, Andrew Voorhees, Susannah Waxman, Ralitsa T. Loewen, Nils A. Loewen, Ian A. Sigal
University of Pittsburgh, Pittsburgh, USA.
O0249 In-Situ Stiffness Characterization of the Inner Wall of Schlemm’s Canal Mark Johnson1, Amir Vahabikashi1, Biqin Dong1, Ernst Tamm2, Cheng Sun1, Hao Zhang1
1Northwestern University, Evanston, USA. 2Universität Regensburg, Regensburg, Germany.
O0250 Trabecular Meshwork Mechanical Stiffness is Strongly Linked to Aqueous Outflow Resistance C. Ross Ethier1, Ke Wang1, A. Thomas Read1, Iris Navarro2, Ashim Mita3, W. Daniel Stamer2, Todd Sulchek1, Guorong Li2
1Georgia Tech, Atlanta, USA. 2Duke University, Durham, USA. 3University of Missouri-Kansas City, Kansas City, USA.
O0251 Does aqueous humour drainage from the eye depend on cellular metabolism? Ester Reina-Torres, Alexandra Boussommier-Calleja, Joseph M. Sherwood, Darryl R. Overby
Department of Bioengineering, Imperial College London, London, United Kingdom.
O0252 Iris Stromal Cell Nuclear Aspect Ratio Alters During Pupil Dilation Neda Rashidi1, Syril Dorairaj2, Anup Pant1, Mickey Shah1, Ge Zhang1, Vineet Thomas1, Rouzbeh Amini1
1The University of Akron, Akron, USA. 2Mayo Clinic, Jacksonville, USA.
O0255 Tibio-femoral contact force distribution only partially governs pivoting in TKA Adam Trepczynski1, Ines Kutzner1, Jörn Dymke1, William R Taylor2, Pascal Schütz2, Georg Bergmann1, Philipp von Roth3, Georg N Duda1
1Julius Wolff Institut, Charité – Universitätsmedizin Berlin, Berlin, Germany. 2Institute for Biomechanics, ETH, Zürich, Switzerland. 3Center for Musculoskeletal Surgery, Charité – Universitätsmedizin Berlin, Berlin, Germany.
O0256 Comparison of Computational Methods for the Calculation of Femoral Strain during Normal Activity Hamed Ziaei Poor, Saulo Martelli, Mark Taylor
Medical Devices Research Institute, College of Science and Engineering, Flinders University, Adelaide, Australia.
O0257 Using an inverse bone remodelling approach to predict joint loads: Sensitive enough to detect different habitual activities? Alexander Synek1, Christopher J. Dunmore2, Tracy Kivell2,3, Matthew M. Skinner2,3, Dieter Pahr1,4
1Institute of lightweight design and structural biomechanics, TU Wien, Vienna, Austria. 2School of Anthropology and Conservation, University of Kent, Canterbury, United Kingdom. 3Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany. 4Department of Anatomy and Biomechanics, Karl Landsteiner Private University of Health Sciences, Krems, Austria.
O0258 Biomechanical stimulation of the fetal skeleton linked to risk factors for developmental dysplasia of the hip Stefaan W. Verbruggen1, Bernhard Kainz2, Susan C. Shelmerdine3, Owen J. Arthurs3,4, Joseph V. Hajnal5, Mary A. Rutherford6, Andrew T.M. Phillips7, Niamh C. Nowlan1
1Department of Bioengineering, Faculty of Engineering, Imperial College London, London, United Kingdom. 2Department of Computing, Faculty of Engineering, Imperial College London, London, United Kingdom. 3Department of Radiology, Great Ormond Street Hospital, London, United Kingdom. 4UCL Great Ormond Street Institute of Child Health, London, United Kingdom. 5Division of Imaging Sciences, Department of Biomedical Engineering & Centre for the Developing Brain, Kings College London, London, United Kingdom. 6Division of Imaging Sciences, Department of Perinatal Imaging and Health & Centre for the Developing Brain, Kings College London, London, United Kingdom. 7Structural Biomechanics, Department of Civil and Environmental Engineering, Imperial College London, London, United Kingdom.
O0262 Augmented brain-penetrating nanoparticle dispersion and non-viral transfection via brain tissue pre-treatment with pulsed focused ultrasound Colleen T. Curley1, Brian P. Mead1, Namho Kim2, Karina Negron2, Ji Song1, G. Wilson Miller1, William Garrison1, Alexander Klibanov1, Jung Soo Suk2, Justin Hanes2, Richard J. Price1
1University of Virginia, Charlottesville, USA. 2Johns Hopkins University, Baltimore, USA.
O0263 Shear-responsive DNA-origami nano-carriers for targeted drug delivery applications Oren M. Rotman1, Matan Yah Ben-Zion2, Shmuel Einav1, Nadrian C. Seeman3, Danny Bluestein1
1Biomedical Engineering Department, Stony Brook University, Stony Brook, NY, USA. 2Department of Physics, New York University, New York, NY, USA. 3Department of Chemistry, New York University, New York, NY, USA.
O0264 Ultrafast pulsed laser induced nanocrystal transformation in colloidal plasmonic vesicles Mohammad Rezaul Karim1, Xiuying Li1, Peiyuan Kang1, Jaona Randrianalisoa2, Zhenpeng Qin1,3, Dong Qian1
1University of Texas at Dallas, Richardson, USA. 2University of Reims Champagne-Ardenne, Reims, France. 3University of Texas Southwestern Medical Center, Dallas, USA.
O0265 Vascularized Liver and Tumor Microenvironments for Determination of Transport and Delivery of Drugs Alican Ozkan1, Neda Ghousifam1, Rhys Michna1, Marissa Nichole Rylander1,2,3
1Department of Mechanical Engineering, The University of Texas at Austin, Austin, TX, USA. 2Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA. 3Institute of Computational Engineering and Sciences, The University of Texas at Austin, Austin,TX, USA.
O0266 Development of a Gene-Activated Nerve Guidance Conduit for Peripheral Nerve Repair William Lackington1,2,3, Rosanne Raftery1,2,3, Fergal O'Brien1,2,3
1Tissue Engineering Research Group, Royal College of Surgeons in Ireland, Dublin, Ireland. 2Trinity Center for Bioengineering, Trinity College Dublin, Dublin, Ireland. 3Advanced Materials and Bioengineering Research Center, Dublin, Ireland.
O0268 A 3D Rigid-Registration Approach for the Quantification of Bone Periosteal and Endosteal Changes over Time from HRpQCT Images Bert van Rietbergen1,2, Emmanuel Biver3, Thierry Chevalley3, Keita Ito1,4, Roland Chapurlat5, Serge Ferrari3
1Orthopaedic Biomechanics, Dept. Biomed. Eng., Eindhoven, Netherlands. 2Dept. Orthopaedics, Maastricht University Medical Centre, Maastricht, Netherlands. 3Division of Bone Diseases, University Hospitals and Faculty of Medicine, Geneva, Switzerland. 4Dept. Orthopaedics, University Medical Center Utrecht, Utrecht, Netherlands. 5INSERM UMR 1033, Université de Lyon, Lyon, France.
O0269 Collagen Network Connectivity May Predict Fracture Toughness of Human Cortical Bone in Aging and Disease Thomas Willett1, Daniel Dapaah1, Sasidhar Uppuganti2, Mathilde Granke2, Jeffry Nyman2
1University of Waterloo, Waterloo, Canada. 2Vanderbilt University Medical Centre, Nashville, USA.
O0270 FE Prediction of Critical Falling Configurations in High Risk Fracture Patients Mohamad I Z Ridzwan1,2, Bidyut Pal1,3, Richard V Arkel1, Monica Khanna4, Shirley Fetherston5, Lesley Honeyfield6, Richard Abel7, Justin Cobb7, Ulrich Hansen1
1Department of Mechanical Engineering, Imperial College London, London SW7 2AZ, United Kingdom. 2School of Mechanical Engineering, Engineering Campus, Universiti Sains Malaysia, Penang, Malaysia. 3School of Engineering, University of Portsmouth, Portsmouth, PO1 3DJ, United Kingdom. 4Department of Clinical Imaging, Imperial College Healthcare NHS Trust, London, United Kingdom. 5Department of Radiology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom. 6Imaging Offices, 2 North, Charing Cross Hospital, London, United Kingdom. 7Department of Surgery and Cancer, Imperial College London, Charing Cross Hospital, London W6 8RF, United Kingdom.
O0272 The Relationship Between Stiffness and Strength in the Proximal Femur is Sex- and Age-Dependent Daniella Patton1, Erin Bigelow1, Stephen Schlecht1, Todd Bredbenner2, Karl Jepsen1
1University of Michigan, Ann Arbor, USA. 2University of Colorado Colorado Springs, Colorado Springs, USA.
O0273 Reducing osteoporotic hip fractures, predictively Pinaki Bhattacharya, Zainab Altai, Muhammad Qasim, Marco Viceconti
INSIGNEO institute for in silico medicine and Department of Mechanical Engineering, University of Sheffield, Sheffield, United Kingdom.
O0274 Design Optimization of a Biconcave Mobile-bearing Total Disc Arthroplasty Chaochao Zhou1, Ryan Willing1,2
1Department of Mechanical Engineering, State University of New York at Binghamton, Binghamton, USA. 2Department of Mechanical and Materials Engineering, Western University, London, Canada.
O0275 Importance of bone condition and subject weight in choice of the acetabular shell design: A study of biomechanical response through finite element analysis. Subhomoy Chatterjee1, Sabine Kobylinski1,2, Bikramjit Basu1
1Indian Institute of Science, Bangalore, India. 2University of Applied Science, Regensburg, Germany.
O0276 Subchondral bone cysts in the equine medial femoral condyle increase stress in the bone and meniscus Lance Frazer1, Elizabeth Santschi2, Kenneth Fischer1
1University of Kansas, Lawrence, USA. 2Kansas State University, Manhattan, USA.
O0277 Towards in silico analysis of hip joint stability. Karen Fitzgerald1, Philip Cardiff1, Alojz Ivankovic1, Rob Flavin1,2
1University College Dublin, Dublin, Ireland. 2St. Vincents University Hospital, Dublin, Ireland.
O0278 Biomechanical evaluation of a novel elastomer cervical total disc replacement:A finite element study A Kiapour1, JM Zavatsky2, VK Goel1
1Engineering Center for Orthopaedic Research Excellence, Department of Bioengineering, The University of Toledo, Toledo, OH, USA. 2Spine & Scoliosis Specialists, Tampa, FL, USA.
O0279 Biomechanical analysis of knee joint contact forces with gait evaluation before and after total knee arthroplasty Kuan Zhang1,2, Jun Sun3, Jizhou Zeng4, Songhua Yan1,2, Jiageng Liu1,2
1School of Biomedical Engineering, Capital Medical University, Beijing, China. 2Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing, China. 3Youan Hospital, Capital Medical University, Beijing, China. 4Department of Orthopedics, Beijing Lu He Hospital, Capital Medical University, Beijing, China.
O0280 Development of a novel Matlab-based framework for implementing mechanical joint stability constraints within OpenSim musculoskeletal models Mohammadhossein Akhavanfar1, Ryan Graham1, Stephen H.M. Brown2, Scott C.E. Brandon2
1University of Ottawa, Ottawa, Canada. 2University of Guelph, Ontatio, Canada.
O0282 Evaluation of Joint Contact Pressure in Four Subject Specific Discrete Element Based Models of the Ankle Joint Ivan Benemerito1,2, Luca Modenese1,3, Erica Montefiori1,3, Claudia Mazzà1,3, Marco Viceconti1,3, Damien Lacroix1,3, Lingzhong Guo1,2
1INSIGNEO Institute for in silico medicine, The University of Sheffield, Sheffield, United Kingdom. 2Department of Automatic Control and Systems Engineering, The University of Sheffield, Sheffield, United Kingdom. 3Department of Mechanical Engineering, The University of Sheffield, Sheffield, United Kingdom.
O0285 Fibroblast growth factor signaling regulates eminence size, bone shape, and remodeling during postnatal growth Megan Killian1, David Ornitz2, Michael Sonnenfelt1
1University of Delaware, Newark, USA. 2Washington University, St Louis, USA.
O0288 Spatially Organized 3D-Printed Scaffolds to Mimic the Osteochondral Interface Hafiz Busari, Peter Schwarzenberg, Paula Camacho, Katherine Hudson, Hannah Dailey, Lesley Chow
Lehigh University, Bethlehem, Pennsylvania, USA.
O0290 The role of mechanics in individual and collective cell migration: a computer-based study Ismael González-Valverde, Jorge Escribano, Clara Valero, Carlos Borau, José Manuel García-Aznar
Universidad de Zaragoza, Zaragoza, Spain.
O0292 The Mechanobiology of Adipocytes Revealed Through Multiscale Experimental-Computational Models of Diabesity Amit Gefen1, Maayan Lustig1, Dafna Benayahu2
1Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel. 2Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
O0294 Computational modelling of cell and tissue mechanics based on cytoskeletal dynamics Marino Arroyo1,2, Sohan Kale1, Ernest Latorre1,2, Xavier Trepat2, Alejandro Torres-Sanchez1, Guillermo Vilanova1, Adam Ouzeri1
1Universitat Politecnica de Catalunya-BarcelonaTech, Barcelona, Spain. 2Institute for Bioengineering of Catalonia, Barcelona, Spain.
O0295 Mechanosensitivity of crawling cells John Molina1, Ryoichi Yamamoto1,2
1Department of Chemical Engineering, Kyoto University, Kyoto, Japan. 2Department of Fundamental Engineering, The University of Tokyo, Tokyo, Japan.
O0296 Role of contact inhibition of locomotion and junctional mechanics in epithelial collective responses to injury Luke Coburn1, Guillermo Gomez2, Hender Lopez3, Vladimir Lobaskin3
1Institute of Complex Systems and Mathematical Biology, University of Aberdeen, Aberdeen, United Kingdom. 2University of Queensland, Brisbane, Australia. 3University College Dublin, Dublin, Ireland.
O0297 Cell adhesion during bullet and rolling motion in capillaries Naoki Takeishi1, Yohsuke Imai2, Roger Kamm3
1Osaka University, Osaka, Japan. 2Tohoku University, Sendai, Japan. 3Massachusetts Institute of Technology, Cambridge, USA.
O0298 Biomechanical effects of ankle arthrodesis and total ankle arthroplasty surgeries on foot Yan Wang1,2, Qitao Tan1,2, Zengyong Li3, Ming Zhang1,2
1Department of Biomedical Engineering, Hong Kong Polytechnic University, Kowloon, Hong Kong. 2The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China. 3Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability, National Research Center for Rehabilitation Technical Aids, Beijing, China.
O0299 Fascicle behavior of human medical gastrocnemius during isometric contraction after stroke Jongsang Son1,2, Fatemeh Saadat1,2, Sabrina S.M. Lee2, William Zev Rymer1,2
1Shirley Ryan AbilityLab (formerly Rehabilitation Institute of Chicago), Chicago, USA. 2Northwestern University, Chicago, USA.
O0300 Static optimization underestimates co-activation during gait in patients with and without neuromuscular impairment Elyse Passmore1,2,3, Morgan Sangeux1,2,3
1Murdoch Children's Research Institute, Melbourne, Australia. 2The Royal Children's Hospital, Melbourne, Australia. 3University of Melbourne, Melbourne, Australia.
O0301 Topological Defects in epithelia govern cell death and extrusion Thuan Beng Saw1,2, Amin Doostmohammadi3, Vincent Nier4, Philippe Marcq4, Chwee Teck Lim1,2, Julia M. Yeomans3, Benoit Ladoux1
1Mechanobiology Institute, National University of Singapore, NUS, Singapore, Singapore. 2Biomedical EngineeringDepartment, NUS, Singapore, Singapore. 3The Rudolf Peierls Centre for Theoretical Physics, University of Oxford, UK, Oxford, United Kingdom. 4Laboratoire Physico-Chimie Curie, Sorbonne Universités, UPMC Université Paris 6, Institut Curie, Paris, France.
O0304 Internal Strain in The Proximal Human Femur: A Digital Volume Correlation Analysis of Time-Lapsed Synchrotron-Light Images of Femoral Fracture Saulo Martelli1, Mario Giorgi2, Enrico Dall'Ara2, Egon Perilli1
1College of Science and Engineering, Flinders University, Adelaide, Australia. 2Insigneo institute for in silico medicine, the University of Sheffield, Sheffield, United Kingdom.
O0305 MicroCT and Digital Volume Correlation Measurement of Strain in the Intervertebral Disc Catherine Disney1, Brian Bay2, Judith Hoyland1, Peter Lee1, Michael Sherratt1
1The University of Manchester, Manchester, United Kingdom. 2Oregon State University, Corvallis, USA.
O0306 Full-field strain analysis of newly formed bone induced by BMP-2 loaded hydrogels Marta Peña Fernández1, Cameron Black2, Jon Dawson2, David Gibbs2, Janos Kanczler2, Richard OC Oreffo2, Gianluca Tozzi1
1Zeiss Global Centre, University of Portsmouth, Portsmouth, United Kingdom. 2Bone & Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, University of Southampton, Southampton, United Kingdom.
O0307 OCT-DVC tridimensional measurements of layer-specific strain fields around an ostium in a porcine aorta subjected to tensile loading M. Flechas García1,2,3, V.A. Acosta Santamaría1,2,3, J. Molimard1,2,3, S. Avril1,2,3
1SaInBioSE, INSERM, Saint-Étienne, France. 2Mines Saint-Étienne, Saint-Étienne, France. 3Université de Lyon, Saint-Étienne, France.
O0308 Accurate and noise insensitive strain mapping enables ultrasound analysis of cardiac function in three dimensions John Boyle1,2, Arvin Soepriatna3, Frederick Damen3, Robert Pless4, Attila Kovacs2, Craig Goergen3, Stavros Thomopoulos1, Guy Genin2
1Columbia University, New York, USA. 2Washington University in St Louis, Saint Louis, USA. 3Purdue University, West Lafayette, USA. 4George Washington University, Washington DC, USA.
O0309 Engineering a highly elastic and adhesive surgical sealant Nasim Annabi1,2, Yi-Nan Zhang2, Alexander Alexander Assmann2, Ehsan Shirzaei Sani1, Andrea Vegh2, George Cheng3, Bijan Dehghani2, Guillermo Ulises Ruiz-Esparza2, Xichi Wang2, Antonio Lassaletta3, Sidhu Gangadharan3, Anthony S. Weiss4, Ali Khademhosseini2
1Department of Chemical Engineering, Northeastern University, Boston, USA. 2Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, USA. 3Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Boston, USA. 4School of Life and Environmental Sciences, University of Sydney, Sydney, Australia.
O0310 New approaches including high-throughput for the engineering of musculoskeletal tissues Rui L. Reis,
3B’s Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909 Taipas, Guimarães, Portugal. ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
O0311 The Activity for establishment of the national registry for biomechanical products and National Regenerative Medicine Database. Kiyoshi Okada1,2, Yoji Sato3, Yoshiki Sawa4
1Japanese Society for Regenerative Medicine, Tokyo, Japan. 2Osaka University Hospital, Osaka, Japan. 3National Institute of Health Science, Tokyo, Japan. 4Osaka University Graduate School of Medicine, Osaka, Japan.
O0312 A quantitative study on magnesium alloy biodegradation process Lizhen Wang1,2, Yuanming Gao1,2, Xingyu Fan3, Tong Ha1,2, Xiong Jiang1,2
1Key laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, China. 2Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, China. 3College of Bioengineering, Chongqing University, Chongqing, China.
O0315 Micropore-generated capillary forces to aid in bone regeneration Laurence Rustom1, Thomas Boudou2,3, Catherine Picart2,3, Brett Nemke4, Yan Lu4, Mark Markel4, Amy Wagoner Johnson5
1University of Illinois, Urbana, USA. 2CNRS, Grenoble, France. 3University of Grenoble Alpes, Grenoble, France. 4University of Wisconsin, Madison, USA. 5University of Illinois at Urbana-Champaign, Urbana, USA.
O0319 Structural-elastic determination of the lifetime of biomolecules under force Jie Yan1, Shiwen Guo1, Qingnan Tang2
1National University of Singapore, Singapore, Singapore. 2Singapore, Singapore, Singapore.
O0325 The interplay between gait variability, falls and cognitive function: evidence from dual-tasking, imaging, and a multi-modal intervention Jeffrey M. Hausdorff,,
Center for the Study of Movement, Cognition, and Mobility, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. Sagol School of Neuroscience and Department of Physical Therapy, Tel Aviv University, Tel Aviv, Israel. Rush Alzheimer’s Disease Center and Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois, USA.
O0327 Posterior single-stepping thresholds are predictive of falls in older, ambulatory women Jeremy Crenshaw1, Kathie Bernhardt2, Elizabeth Atkinson2, Sara Achenbach2, Sundeep Khosla2, Shreyasee Amin2, Kenton Kaufman2
1University of Delaware, Newark, DE, USA. 2Mayo Clinic, Rochester, MN, USA.
O0328 Fall risk in Virtual Reality systems: Visual field dependence predicts prospective falls among older adults Erika Pliner1,2, Anne Tiedemann3, Stephen Lord2
1University of Pittsburgh, Pittsburgh, USA. 2Neuroscience Research Australia, Randwick, Australia. 3The University of Sydney, Sydney, Australia.
O0331 Perturbative experiment validates quantitative method of stability estimation for Sit-To-Stand Patrick Holmes1, Shannon Danforth1, Talia Moore1, Xiao-Yu Fu2, Ram Vasudevan1
1University of Michigan, Ann Arbor, USA. 2University of Calgary, Calgary, Canada.
O0332 Effect of Materials on Stent Deployment Georgia Karanasiou1, Nikolaos Tachos1, Antonios Sakellarios1, Lampros Michalis2, Claire Conway3,4, Elazer Edelman5,6, Dimitrios Fotiadis7,1
1Department of Biomedical Research, Institute of Molecular Biology and Biotechnology, FORTH, Ioannina, Greece. 2Department of Cardiology, Medical School, University of Ioannina, Ioannina, Greece. 3Biomedical Engineering, National University of Ireland Galway, Galway, Ireland. 4Institute for Medical Engineering and Science, Massachusetts Institute of Technology,, Cambridge, USA. 5Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, USA. 6CBSET, Lexington, USA. 7University of Ioannina, Department of Materials Science, Unit. of Medical Technology and Intelligent Information Systems, Ioannina, Greece.
O0334 Real-time simulation of stent deployment and blood flow through a blood vessel with stent Tijana Djukic1, Igor Saveljic1,2, Nenad Filipovic1,2,3
1Bioengineering Research and Development Center, BioIRC, Kragujevac, Serbia. 2Faculty of Engineering, University of Kragujevac, Kragujevac, Serbia. 3Harvard School of Public Health, Harvard University, Boston, USA.
O0335 A novel poroelastic model of the neuro-glio-vascular unit Dean Chou1, John Vardakis2, Yiannis Ventikos2
1National Central University, Taoyuan, Taiwan. 2University College London, London, United Kingdom.
O0336 Geometry Optimization of Nitinol Stent Design: Comparing Old vs. New Design - Finite Element Analysis Dalibor Nikolic1, Igor Saveljic1,2, Nenad Filipovic1,2
1Research and development center for bioengineering - BioIRC, Kragujevac, Serbia. 2Faculty of engineering, University of Kragujevac, Kragujevac, Serbia.
O0337 Experimental classification of Intracranial Aneurysm tissue: from strain/stress relationships to fluorescent properties Daniil Parshin1,2, Nikolay Maslov3, Alexander Yunoshev1,2, Alexander Khe1,2, Alexander Chupakhin1,2
1Lavrentyev Institute of Hydrodynamics SB RAS, Novosibirsk, Russian Federation. 2Novosibirsk State University, Novosibirsk, Russian Federation. 3Institute of Theoreteical and Applied Mechanics SB RAS, Novosibirsk, Russian Federation.
O0338 A computational multi-level patient-specific model for the simulation of the mechanisms of atherosclerotic plaque growth Antonis Sakellarios1, Nikolaos Tachos1, Panagiota Tsompou2, Vasiliki Kigka2, Savvas Kyriakidis1, Georgia Karanasiou1, Gualtriero Pelosi3, Oberdan Parodi3, Dimitrios Fotiadis1,2
1Department of Biomedical Research, Institute of Molecular Biology and Biotechnology – FORTH, Ioannina, Greece. 2Unit of Medical Technology and Intelligent Information Systems, Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece. 3Institute of Clinical Physiology, CNR, Pisa, Italy.
O0339 A biofidelity evaluation of the WIAMan Gen1 prototype Hollie Pietsch1, Terrance Smith2
1US Army Tank Automotive Research Development and Engineering Center, Warren, MI, USA. 2Dynamic Resesarch, Inc, Torrance, CA, USA.
O0340 An investigation of the human pelvic response to underbody blast scenarios Preston Greenhalgh1, E. Meade Spratley1, JiangYue Zhang2, Suzanne Bilodeau3, Robert Salzar1
1Center for Applied Biomechanics, University of Virginia, Charlottesville, VA, USA. 2Johns Hopkins University Applied Physics Laboratory, Laurel, MD, USA. 3Army Research Laboratory, Aberdeen, MD, USA.
O0341 Scaling effects on injury risk curves for femoral mid-shaft bending fracture Alexander Baker1, Jonathan Hendricks1, Ashley Weaver1, Meade Spratley2, Robert Salzar2, Cameron Bass3, Liming Voo4
1Wake Forest Center for Injury Biomechanics, Winston-Salem, USA. 2University of Virginia, Charlottesville, USA. 3Duke University, Durham, USA. 4Johns Hopkins University Applied Physics Laboratory, Laurel, USA.
O0342 Generating Human Injury Probability Curves for the Upper Cervical Spine under UBB Loading Liming Voo1, Thomas Metzger1, Christopher Dooley1, Kyle Ott1, John Clark1, Jeseph Andrist1, Suzanne Bilodeau2, Andrew Merkle1
1Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland, USA. 2Army Research Laboratory, Aberdeen, Maryland, USA.
O0343 Developing Injury Assessment Reference Curve for WIAMan Foot Injury Prediction Capability Liming Voo1, Eyal Bar-Kochba1, Kyle Ott1, Thomas Metzger1, Mary Luongo1, David Drewry1, Suzanne Bilodeau2, Andrew Merkle1
1Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland, USA. 2US Army Research Laboratory, Aberdeen, Maryland, USA.
O0345 Evaluation of four strategies to decrease Normalized Confidence Interval Size of injury risk curves Alexander Baker1, Fang-Chi Hsu1, Robert Salzar2, Meade Spratley2, Liming Voo3, Scott Gayzik1
1Wake Forest University School of Medicine, Winston-Salem, USA. 2University of Virginia, Charlottesville, USA. 3Johns Hopkins University Applied Physics Laboratory, Laurel, USA.
O0346 Kinematic and biomechanical response of post-mortem human subjects in various pre-impact postures to high-rate vertical loading conditions Lauren Wood Zaseck1, Anne C Bonifas1, Carl S Miller1, Nichole Ritchie Orton1, Matthew P Reed1, Constantine K Demetropoulos2, Kyle A Ott2, Christopher J Dooley2, Nathanael P Kuo2, Leah M Strohsnitter2, Joseph R Andrist2, Mary E Luongo2, David G Drewry III2, Andrew C Merkle2, Jonathan D Rupp3
1University of Michigan Transportation Research Institute, Ann Arbor, USA. 2The Johns Hopkins University Applied Physics Laboratory, Laurel, USA. 3Emory University, Atlanta, USA.
O0347 Response of female and male PMHS lower extremity to blast-induced vertical accelerative loading Danielle Cristino1, Patricia Frounfelker2, Aaron Alai3, Andrew Kemper1, Hollie Pietsch4, Kerry Danelson5, John Bolte IV6, Warren Hardy1
1Center for Injury Biomechanics, Virginia Polytechnic Institute and State University, Blacksburg, USA. 2US Army Research Laboratory, Survivability/Lethality Analysis Directorate, Aberdeen, USA. 3SRUVICE Engineering, Belcamp, USA. 4U.S. Army Tank Automotive Research, Development and Engineering Center, Warren, USA. 5Department of Orthopaedic Surgery, Wake Forest School of Medicine, Winston-Salem, USA. 6Injury Biomechanics Research Center, The Ohio State University, Columbus, USA.
O0348 Elasticity models for dispersion in fibrous soft biological tissues Ray Ogden1, Gerhard Holzapfel2, Kewei Li2
1University of Glasgow, Glasgow, United Kingdom. 2Graz University of Technology, Graz, Austria.
O0349 A validated computational model for vascular growth and remodeling with maturation, low oscillatory shear stress and increased arterial stiffness. Alex Cetnar1, Anastassia Pokutta-Paskaleva1, Luke Brewster2, Rudolph Gleason1
1Georgia Institute of Technology, Atlanta, GA, USA. 2Emory University, Atlanta, GA, USA.
O0350 Microstructure-scale finite element model of the tunica adventitia under tensile loading Venkat Siva Radha Krishna Ayyalasomayajula1,2,3, Baptiste Pierrat1,2,4, Pierre Badel1,2,4
1Ecole Nationale Supérieure des Mines de Saint-Etienne, Center CIS, Saint Etienne, France. 2Universite de Lyon, Lyon, France. 3INSERM SainBioSE U1059, Saint Etienne, France. 4INSERM SainBioSE U1059, Saint Etienne, France.
O0351 A structural finite element model of the ascending thoracic aorta James Thunes, Julie Phillippi, Thomas Gleason, David Vorp, Spandan Maiti
University of Pittsburgh, Pittsburgh, USA.
O0352 Modeling Fiber Recruitment and Damage with a Discrete Fiber Dispersion Method Kewei Li1, Gerhard A. Holzapfel1,2
1Graz University of Technology, Graz, Austria. 2Norwegian University of Science and Technology, Trondheim, Norway.
O0354 Effects of intermittent hypoxia and ageing on the passive stiffness of ventricular myocardium in a mouse model of sleep apnea Jorge Otero1,2, Nuria Farré3,4,5, Ignasi Jorba1,6, Isaac Almendros1,2,7, Ramon Farré1,2,7, Daniel Navajas1,2,6
1Unitat de Biofísica i Bioenginyeria. Facultat de Medicina. Universitat de Barcelona, Barcelona, Spain. 2CIBER de Enfermedades Respiratorias, Madrid, Spain. 3Heart Failure Unit, Department of Cardiology, Hospital del Mar, Barcelona, Spain. 4Heart Diseases Biomedical Research Group, IMIM, Barcelona, Spain. 5Department of Medicine. Universitat Autònnoma de Barcelona, Barcelona, Spain. 6Institut de Bioenginyeria de Catalunya, Barcelona, Spain. 7Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer, Barcelona, Spain.
O0355 Characterising the oscillatory mechanical forces in the aqueous humour outflow pathway Joseph Sherwood1, W. Daniel Stamer2, Darryl Overby1
1Imperial College London, London, United Kingdom. 2Duke University, Durham, USA.
O0356 Investigating the sensitivity of intraocular pressure-induced optic nerve head strains to variations in optic nerve head geometry and material properties using finite element modeling Stephen Schwaner1, Hongli Yang2, Marta Pazos3, Elaine Johnson4, John Morrison4, Claude Burgoyne2, C. Ross Ethier1
1Georgia Institute of Technology, Atlanta, GA, USA. 2Devers Eye Institute, Portland, OR, USA. 3Hospital de l'Esperanca-Parc de Salut Mar., Barcelona, Spain. 4Oregon Health and Science University, Portland, OR, USA.
O0357 Biomimetic modelling of the glaucomatous lamina cribrosa region of the optic nerve head using tissue engineered scaffolds. Deirdre Clissmann1, Rory Murphy2,3, Rebecca Low1,2, Alan Hopkins2,3, Mustapha Irnaten2,3, Deborah Wallace2, Alan Hibbitts4, Alan Ryan4, Fergal O'Brien4, Colm O'Brien2,3, Deirdre Brennan1
1Anatomy, School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland. 2Clinical Research Centre, Catherine McAuley Centre, School of Medicine, University College Dublin, Nelson Street, Dublin 7, Ireland. 3Institute of Ophthalmology, Mater Misericordiae University Hospital, 60 Eccles Street, Dublin 7, Ireland. 4Tissue Engineering Research Group (TERG), Dept. of Anatomy, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.
O0358 Lamina cribrosa deformations due to increased IOP are different, usually larger, when alive than after death Junchao Wei1, Andrew P. Voorhees1, Samantha Schmitt1, Po Lam1, Hiroshi Ishikawa2, Joel S. Schuman2, Matthew A. Smith1, Gadi Wollstein2, Ian A. Sigal1
1University of Pittsburgh, Pittsburgh, USA. 2NYU School of Medicine, New York, USA.
O0359 Early Ovariectomy Affects Ocular Compliance and Aqueous Outflow Facility Andrew Feola1,2, Joseph M. Sherwood3, Darryl R. Overby3, Machelle Pardue1,2, C. Ross Ethier2
1Atlanta VA Medical Center, Atlanta, USA. 2Georgia Institute of Technology, Atlanta, USA. 3Imperial College London, London, United Kingdom.
O0361 Biomechanical characterization and interrupted mechanical testing of the porcine optic nerve Katherine M. Copeland1, Sammira Rais-Rohani2, Sara McMahan1, Sarah Fitzgerald2, Bryn Brazile2, Richard Summers3, Robert Hester3, Raj Prabhu2, Lakiesha Williams2, Yi Hong1, Jun Liao1
1University of Texas at Arlington, Department of Bioengineering, Arlington, USA. 2Mississippi State University, Department of Agricultural and Biological Engineering, Mississippi State, USA. 3University of Mississippi Medical Center, Department of Physiology and Biophysics, Jackson, USA.
O0362 Novel Intraocular Pressure Measurement Algorithm for Patients with Keratoconus Ashkan Eliasy1, Kai-Jung Chen1, Riccardo Vinciguerra1,2, Ahmed Elsheikh1,3
1School of Engineering, University of Liverpool, Liverpool, United Kingdom. 2St Paul’s Eye Unit, Royal Liverpool and Broadgreen University Hospital, Liverpool, United Kingdom. 3NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom.
O0363 Investigation of the effect of fibrous structure of the human lens on accommodation using finite element method Reza Kakavand1, Mohammad Ali Nazari1, S. Farzad Mohammadi2, Ali Asghar Ataee1, Speideh Jamali2
1School of Mechanical Engineering, University of Tehran, Tehran, Iran, Islamic Republic of. 2Translational ophthalmology research center, Tehran university of medical science, Tehran, Iran, Tehran, Iran, Islamic Republic of.
O0364 Potential effects of thorax and rib cage joint rigidity on thoracolumbar spinal loading Hossein Mokhtarzadeh1,2, Dennis Anderson1,2, Mary Bouxsein1,2
1Harvard Medical School, Boston, USA. 2Beth Israel Deaconess Medical Center, Boston, USA.
O0365 Hip articular contact forces in femoroacetabular impingement syndrome using EMG-informed neuromusculoskeletal modelling Trevor N. Savage1,2, Hoa X. Hoang3,1, David J. Saxby3,1, Claudio Pizzolato3,1, Edin K. Suwarganda3,1, Michelle Hall4, Tim V. Wrigley4, Kim L. Bennell4, Thor F. Besier5, David J. Hunter2,6, David G. Lloyd3,1
1School of Allied Health Sciences, Griffith University, Gold Coast, QLD, Australia. 2Institute of Bone and Joint Research, Kolling Institute, The University of Sydney, Sydney, NSW, Australia. 3Gold Coast Orthopaedic Research and Education Alliance, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia. 4Centre for Health, Exercise and Sports Medicine, University of Melbourne, Melbourne, Australia. 5Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand. 6Rheumatology Department, Royal North Shore Hospital, St. Leonards, NSW, Australia.
O0366 Correlation between inter-limb differences (ILDs) in knee biomechanical and biochemical variables 3 and 6 months after anterior cruciate ligament reconstruction (ACLR) Ashutosh Khandha1,2, Jacob Capin2, Jack Williams3, Kurt Manal3, Lynn Snyder-Mackler2,4, Thomas Buchanan1,3
1Delaware Rehabilitation Institute, Newark, USA. 2Biomechanics and Movement Science, University of Delaware, Newark, USA. 3Mechanical Engineering, University of Delaware, Newark, USA. 4Physical Therapy, University of Delaware, Newark, USA.
O0367 Integrating subject-specific tibio-femoral contact point trajectories from 3D/2D registration techniques into musculoskeletal model of the lower limb Ali Zeighami1, Rachid Aissaoui1, Raphael Dumas2
1Laboratoire de Recherche en Imagerie et Orthopédie (LIO), École de Technologie Supérieure (ÉTS), Centre de Recherche du CHUM, Montréal, Québec, Canada. 2Univ Lyon, Université Claude Bernard Lyon 1, IFSTTAR, LBMC UMR_T9406, Lyon, France.
O0368 Dynamic, in-vitro analysis of tibial bone strains in a fixed versus mobile bearing design for unicompartmental knee replacement Orcun Taylan1, Geert Peersman1,2, Joshua Slane1, Ben Vanthienen3, G. Harry van Lenthe3, Thomas J. Heyse4, Lennart Scheys1
1Institute for Orthopaedic Research and Training, KU Leuven / UZ Leuven Campus Pellenberg, Leuven, Belgium. 2ZNA Stuivenberg, Antwerp, Belgium. 3Biomechanics Section, KU Leuven, Leuven, Belgium. 4Center of Orthopedics and Trauma Surgery, University Hospital Marburg, Marburg, Germany.
O0370 Tibial bony morphology and tibiofemoral laxity predict knee mechanics during compression Robert Kent, Dean Wang, Mark Amirtharaj, Brendan Hardy, Danyal Nawabi, Thomas Wickiewicz, Andrew Pearle, Carl Imhauser
Hospital for Special Surgery, New York, USA.
O0371 The effect of grade on lower extremity joint contact forces during running Michael Baggaley1, Gianluca Vernillo1, Nicolas Horvais2, Guillaume Millet1, W. Brent Edwards1
1University of Calgary, Calgary, Canada. 2Salomon SAS, Annecy, France.
O0372 Biomechanics During Quadriceps Resistance Exercise – Effects of the Direction of the Gravity Vector Maria Jönsson1,2, Lena Norrbrand3,2, Lanie Gutierrez-Farewik4,5, Patrik Sundblad6,7, Michael Skipper Andersen8, Hans E Berg9,10
1Dept. of Environmental Physiology, KTH, Royal Institute of Technology, Stockholm, Sweden. 2Swedish Aerospace Physiology Centre, KTH, Royal Institute of Technology, Stockholm, Sweden. 3Dept. of Environmental Physiology, Royal Institute of Technology, Stockholm, Sweden. 4KTH Mechanics, Royal Institute of Technology, Stockholm, Sweden. 5KTH BioMEx Center, Royal Institute of Technology, Stockholm, Sweden. 6Dept. of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden. 7Inst. for Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden. 8Dept. of Materials and Production, Aalborg University, Aalborg, Denmark. 9Dept. of Orthopaedics, Karolinska University Hospital, Stockholm, Sweden. 10Inst. for Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
O0373 Cell-cell junction dynamics and their role in tumor cell transendothelial migration Michelle Chen1,2, Emad Moeendarbary3,1, Roger D. Kamm1
1Massachusetts Institute of Technology, Cambridge, USA. 2Stanford University, Stanford, USA. 3University College London, London, United Kingdom.
O0376 Overcoming cancer drug resistance by pyruvate-mediated targeted production of reactive oxygen species in mitochondria Hai Wang1,2, Zan Gao3, Xiaodong "Chris" Li3, Xiaoming "Shawn" He1,2
1University of Maryland, College Park, USA. 2Ohio State University, Columbus, USA. 3University of Virginia, Charlottesville, USA.
O0377 Tumor Microenvironment of Pontine Glioma Using DCE-MRI and DTI Kulam Magdoom1, Francisco Delgado1, Ana Bohorquez1, Alec Brown1, Paul Carney1, Carlos Rinaldi1, Thomas Mareci1, James Ewing2, Malisa Sarntinoranont1
1University of Florida, Gainesville, USA. 2Henry Ford Hospital, Detroit, USA.
O0378 Role of vascular decompression and functional normalization in benefit from metronomic chemotherapy: Insights from a mathematical model Fotios Mpekris1, James W. Baish2, Triantafyllos Stylianopoulos1, Rakesh K. Jain3
1Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus. 2Department of Biomedical Engineering, Bucknell University, Lewisburg, PA, USA. 3Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, USA.
O0379 Cytoskeletal and nuclear dynamics during sustained biaxial confined migration Andrew Holle1,2, Annika Meid1, Ralf Kemkemer3, Joachim Spatz1,2
1Max Planck Institute for Medical Research, Heidelberg, Germany. 2Institute of Physical Chemistry, Heidelberg, Germany. 3Reutlingen University, Reutlingen, Germany.
O0383 The effect of estrogen withdrawal on osteocyte calcium signaling in vivo Karl J. Lewis1, Joyce Louie2, Samuel Stephen2, David C. Spray3, Mia M. Thi3, Zeynep Seref-Ferlengez3, Robert J. Majeska2, Sheldon Weinbaum2, Mitchell B. Schaffler2
1Indiana University School of Medicine, Indianapolis, USA. 2The City College of New York, New York, USA. 3Albert Einstein College of Medicine, Bronx, USA.
O0384 Preclinical models of post-traumatic osteoarthritis: biomechanical and pathological comparisons of two ACL injury models. Carina Blaker1,2, Sanaa Zaki2, Christopher Little2, Elizabeth Clarke1
1Murray Maxwell Biomechanics Laboratory, Institute of Bone and Joint Research, Kolling Institute, Northern Sydney Local Health District, Sydney Medical School, University of Sydney, St. Leonards, Australia. 2Raymond Purves Bone and Joint Research Laboratories, Institute of Bone and Joint Research, Kolling Institute, Northern Sydney Local Health District, Sydney Medical School, University of Sydney, St. Leonards, Australia.
O0390 Functional determination of a cervical spine joint coordinate system via an optimization approach Matthew Moran1, Paul Ullucci, Jr.1, Frank Tudini2
1Sacred Heart University, Fairfield, USA. 2Campbell University, Buies Creek, USA.
O0392 The Subject-Specific FE Modeling of the Inferior Cervical Spine Maxim Van den Abbeele, Pierre Coloma, Sebastien Laporte, Baptiste Sandoz, Dominique Bonneau, Cedric Barrey, Wafa Skalli
Arts et Metiers ParisTech, Institut de Biomecanique Humaine Georges Charpak, Paris, France.
O0394 Modelling articular cartilage as a dynamic tissue Bruce Gardiner1, David Smith2, Lihai Zhang3, Saeed Miramini3, Alan Grodzinsky4
1Murdoch University, Perth, Australia. 2The University of Western Australia, Perth, Australia. 3Melbourne University, Melbourne, Australia. 4Massachusetts Institute of Technology, Cambridge, USA.
O0396 The aggregate mechanics of cartilage due to nanoscale degradation Tanvir Faisal1,2, Malek Adouni3, Yasin Dhaher1,2,4
1Dept. of Physical Medicine & Rehabilitation, Northwestern University, Chicago, USA. 2Legs + Walking Lab, Shirley Ryan AbilityLab, Chicago, USA. 3Dept. of Mechanical Engineering, Australian College of Kuwait, East Meshrif, Kuwait. 4Dept. of Biomedical Engineering, Northwestern University, Chicago, USA.
O0397 Subchondral bone mass negatively correlates to load-induced cartilage damage in mice Sophia Ziemian1, Mary Goldring2, Steve Goldring2, Marjolein van der Meulen1,2
1Cornell University, Ithaca, USA. 2Hospital for Special Surgery, New York City, USA.
O0398 Experimental investigation of human cartilage multiscale mechanics. Ashvin Thambyah1, Elizabeth Clarke2
1University of Auckland, Auckland, New Zealand. 2Kolling Institute of Medical Research, Sydney, Australia.
O0399 A mechanobiological model to predict proteoglycan loss in injured cartilage: numerical analysis integrated with experimental results Gustavo Orozco1, Petri Tanska1, Cristina Florea1, Alan Grodzinsky2, Rami Korhonen1
1University of Eastern Finland, Kuopio, Finland. 2Massachusetts Institute of Technology, Massachusetts, USA.
O0400 Novel Laser Treatment Modality for Crosslinking and Strengthening Early-Stage Osteoarthritic Cartilage Krista Durney-Antonelli, Chao Wang, Chieh Hou, Brandon Zimmerman, Shivam Sonar, Léa Montégut, Michael Anne Bolene, Sonia Donde, Katherine Guan, Clark Hung, Gerard Ateshian, Sinisa Vukelic
Columbia University, New York City, USA.
O0404 Discrete element method models of deformable cells in 2D and 3D environments to explore traction generation mechanisms Diego A Vargas1, Tommy Heck1, Bart Smeets2, Paul Van Liedekerke3, Herman Ramon2, Hans Van Oosterwyck1,4
1Mechanical Engineering Department, Biomechanics section, KU Leuven, Leuven, Belgium. 2Division of Mechatronics, Biostatistics and Sensors (MeBioS), KU Leuven, Leuven, Belgium. 3Institute National de Recherche en Informatique et en Automatique, Paris, France. 4Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium.
O0405 Pulsatile signaling in active cytoskeletal networks for embryonic tissue folding Michael Mak1, Adam Martin2, Roger Kamm2
1Yale University, New Haven, USA. 2Massachusetts Institute of Technology, Cambridge, USA.
O0406 Mathematical modeling of nonmuscle myosin dependent cortical stability during cytokinesis Matthew R. Bersi, Nilay Taneja, Aidan M. Fenix, John C. Snider, Dylan T. Burnette, W. David Merryman
Vanderbilt University, Nashville, USA.
O0413 Three-dimensional kinematics of temporo-mandibular joints with moderate dysfunctions compared with the asymptomatic behavior Typhaine Koeppel1,2, Emilie Sapin - de Brosses1,2, Anne-Sophie Bonnet1,2
1Laboratoire d'Etude des Microstructures et de Mécanique des Matériaux, Metz, France. 2Université de Lorraine, Metz, France.
O0414 Assessing and improving human movements using sensitivity analysis and digital human simulation Pauline Maurice1, Vincent Padois2, Yvan Measson3, Philippe Bidaud4
1INRIA Nancy Grand Est, Nancy, France. 2Sorbonne Universités, Université Pierre et Marie Curie, Paris, France. 3CEA LIST, Gif sur Yvette, France. 4ONERA, Palaiseau, France.
O0415 Biomechanical study of the action of compression bandages on the lower leg Fanette Chassagne1,2, Pierre Badel1, Reynald Convert2, Pascal Giraux3, Jérôme Molimard1
1Mines Saint-Etienne, CIS-EMSE, SAINBIOSE, Saint-Etienne, France. 2Thuasne, BP243, 92307 Levallois-Perret cedex, France. 3Department of Physical Medicine and Rehabilitation, Faculty of Medicine, University Jean Monnet, Saint-Etienne, France.
O0418 A novel histogram-based thresholding approach for accurate segmentation of osteocyte lacunae in micro-CT images of human bone biopsies Elliott Goff1, Jonathan P. McKinley1,2, Duncan C. Betts1, Patrik Christen1, Ralph Müller1
1Institute for Biomechanics, ETH Zurich, Zurich, Switzerland. 2Orthopaedic Biomechanics Laboratory, Department of Mechanical Engineering, University of California, Berkeley, Berkeley, USA.
O0419 Cellular hallmarks of bone diseases in 3D: A correlative workflow for micro-computed tomography and serial block-face scanning electron microscopy Patricia Goggin1, Richard O.C. Oreffo2, Philipp Schneider1
1Bioengineering Science Research Group, Faculty of Engineering and the Environment, University of Southampton, Southampton, United Kingdom. 2Bone and Joint Research Group, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
O0420 High resolution SPECT-CT statistical analysis platform enabling group comparisons: cemented vs uncemented Unicondylar Knee Arthroplasty Félix Dandois1, Lucas Beckers1, Laura Slane1, Stijn De Buck1,2, Dirk Ooms2, Koen Van Laere1,2, Hilde Vandenneucker1,2, Lennart Scheys1,2
1KU Leuven, Leuven, Belgium. 2University Hospitals Leuven, Leuven, Belgium.
O0421 Contrast Enhanced Computed tomography (CECT): a potent tool for measuring GAG content in tissue engineered constructs Joao Garcia1, Laura Creemers1, Juha Töyräs2, Harrie Weinans1,3, Behdad Pouran1,3
1University Medical Center Utrecht, Utrecht, Netherlands. 2University of Eastern Finland, Kuopio, Finland. 3TU Delft, Delft, Netherlands.
O0422 Real-time 3D photoacoustic imaging for blood flow visualization in skin micro vessels Yoshifumi Saijo, Ryo Nagaoka, Saaya Yokoshiki, Moe Maeda, Shin Yoshizawa, ShinIchiro Umemura
Tohoku University, Sendai, Japan.
O0424 Does measuring in the frequency or strain-rate domain affect mechanical results? Luca Bartolini1, Davide Iannuzzi1, Giorgio Mattei2,1,3
1Biophotonics & Medical Imaging and LaserLaB, Vrije Universiteit, Amsterdam, Netherlands. 2Optics11 B.V, Amsterdam, Netherlands. 3Department of Anatomy and Embryology, LUMC, Leiden, Netherlands.
O0425 Engineering viscoelasticity in biomaterials Ludovica Cacopardo1,2, Nicole Guazzelli1, Giorgio Mattei1,3, Arti Ahluwalia1,2
1Enrico Piaggio Research Center, University of Pisa, Pisa, Italy. 2Information Engineering Department, University of Pisa, Pisa, Italy. 3Optics 11, Amsterdam, Netherlands.
O0426 New force-controlled testing method for real-time viscoelastic measurements in bioreactors Ludovica Cacopardo1,2, Fiorella Riccio1, Giorgio Mattei1, Arti Ahluwalia1,2
1Enrico Piaggio Research Center, University of Pisa, Pisa, Italy. 2Information Engineering Department, University of Pisa, Pisa, Italy.
O0427 Tissue-level control of cell orientation by geometry sensing on a micromesh Kennedy Omondi Okeyo1, Osamu Kurosawa2, Hidehiro Oana3, Masao Washizu3
1Kyoto University, Kyoto, Japan. 2RIKEN, Kobe, Japan. 3The University of Tokyo, Tokyo, Japan.
O0428 Wear in ceramic-on-ceramic hip replacement: ex-vivo and in-vitro expertise Marwa Ben Braham1,2,3, Jean Geringer4, Leyre Brizuela Madrid5, Carole Bougault5, Saida Youjil5, Samir Hamza2, Yves Berthier3, Ana-Maria Trunfio-Sfarghiu3
11 Université de Tunis El Manar, Ecole Nationale d'Ingénieurs de Tunis, Tunis, Tunisia. 2Université de Carthage, Institut National des sciences Appliquées et de Technologie, Laboratoire de Nanobiotechnologies, UR17ES22, Tunis, Tunisia. 3INSA-Lyon, LaMCoS, CNRS UMR5259, Villeurbanne Cedex, France. 4Ecole Nationale Supérieure des Mines, CIS-EMSE, CNRS, Saint-Etienne, France. 5ICBMS Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, Laboratoire Organisation et Dynamique des Membranes Biologiques, Villeurbanne Cedex, France.
O0429 Coiled coils as molecular force sensors for the extracellular matrix Melis Goktas1, Alberto Sanz de Leon1, Patricia Lopez Garcia1, Isabell Tunn1, Emilia Grad1,2, Kerstin G. Blank1
1Max Planck Institute of Colloids and Interfaces, Mechano(bio)chemistry, Potsdam, Germany. 2Radboud University, Nijmegen, Netherlands.
O0430 Piconewton-sensitive biosensors to investigate molecular forces in cells Carsten Grashoff,
Westfälische Wilhelms University, Münster, Germany. Max Planck Institute of Biochemistry, Munich, Germany.
O0431 Munc18-1 and Vps33 catalyze directional SNARE assemblyby templating SNARE associationMunc18-1 and Vps33 catalyze directional SNARE assemblyby templating SNARE association Junyi Jiao1, Sarah A. Port2, Mengze He1, Richard W. Baker1,3, Yonggang Xu1, Hong Qu1, Frederick M. Hughson2, Yongli Zhang1
1Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA. 2Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. 3Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
O0432 Rationally designed synthetic protein hydrogels with predictable mechanical properties based on single molecule protein mechanics Yi Cao1, Junhua Wu1, Pengfei Li1, Chenling Dong2, Heting Jiang1, Bin Xue1, Xiang Gao1, Meng Qin1, Wei Wang1, Bin Chen3
1Nanjing University, Nanjing, China. 2Zhengjiang University, Hangzhou, China. 3Zhejiang University, Hangzhou, China.
O0434 Structural determinants of alpha catenin force transduction at intercellular adhesions Deborah Leckband1, Samantha Barrick1, Jing Li2, Emad Tajkhorshid1
1University of Illinois, Champaign, USA. 2University of Chicago, Chicago, USA.
O0435 Single-molecule mechanical (un)folding of RNA: Unravelling mRNA structure’s role in translational regulation Gang Chen
Nanyang Technological University, Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Singapore, Singapore.
O0441 Temporal differences in hand placement response after a ladder climbing perturbation Erika Pliner1,2, Na Jin Seo3, Kurt Beschorner1
1University of Pittsburgh, Pittsburgh, USA. 2Neuroscience Research Australia, Randwick, Australia. 3Medical University of South Carolina, Charleston, USA.
O0442 Fall risk assessment with gyro and accelerometer sensors: minimum foot clearance and its variability. Zhe Sun1, Gen Masumoto1, Makoto Takada2, Hiroshige Takeichi1, Andrzej Cichocki1, Shigeho Noda1, Ryutaro Himeno1
1RIKEN, Wako, Japan. 2Life Science Institute, Inc., Tokyo, Japan.
O0444 Analysing the synchronisation of COM motion with music in human standing Victor Gonzalez, Alexander Refsum Jensenius
RITMO Centre for Interdisciplinary Studies in Rhythm, Time, and Motion, University of Oslo, Oslo, Norway.
O0445 The relationship between trunk and foot movement variability during walking is sensitive to separate fallers from non-fallers Jordan Craig1,2, Adam Bruetsch2, Sharon Lynch3, Jessie Huisinga3
1University of Kansas, Lawrence, KS, USA. 2Landon Center on Aging, Kansas City, KS, USA. 3University of Kansas Medical Center, Kansas City, KS, USA.
O0446 A comparison of the Rosenstein and Wolf algorithms for the nonlinear analysis of normal and perturbed gait Tim Foran1,2, Katie Sheahan3, John Gormley4, Rose Anne Kenny2,5, Richard Reilly6
1Medical Physics and Bioengineering Department, St. James's Hospital, Dublin, Ireland. 2Mercer's Institute for Successful Ageing, St. James's Hospital, Dublin, Ireland. 3School of Population Health and Environmental Sciences, Kings College London, London, United Kingdom. 4Discipline of Physiotherapy, School of Medicine, Trinity College, The University of Dublin, Dublin, Ireland. 5Discipline of Medical Gerontology, School of Medicine, Trinity College, The University of Dublin, Dublin, Ireland. 6Trinity Centre for Bioengineering, Trinity College, The University of Dublin, Dublin, Ireland.
O0447 Evaluation of a more sensitive measure for prediction of changes in dynamic postural stability and fall risk. Rita Patterson, Evan Papa, Janice Knebl, Nicoleta Bugnariu
University of North Texas Health Science Center, Fort Worth, USA.
O0448 Age effects on body’s center of mass motion in relation to center of pressure during downhill walking Shih-Wun Hong1, Tsai-Hsueh Leu2, Jia-Da Li3, Tung-Wu Lu3,4
1Department of Physical Therapy, Tzu-CHi University, Hualien, Taiwan. 2Department of Orthopaedic Surgery, Wan-Fang Hospital, Taipei Medical University, Taipei, Taiwan. 3Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan. 4Department of Orthopaedic Surgery, School of Medicine, National Taiwan University, Taipei, Taiwan.
O0450 Multiscale mechanics of cardiovascular tissues: from artery tissues to myocardium to filament networks Gerhard Holzapfel,
Graz University of Technology, Institute of Biomechanics, Graz, Austria. Norwegian University of Science and Technology (NTNU), Faculty of Engineering Science and Technology, Trondheim, Norway.
O0452 Multi-modality and multi-scale experimental characterization of aneurysmal aortic tissue under bulge inflation loading Cristina Cavinato1,2,3, Jerome Molimard1,2,3, Clementine Helfenstein-Didier1,2,3, Sabine Rolland du Roscoat4, Laurent Orgéas4, Salvatore Campisi5, Pierre Badel1,2,3
1Ecole Nationale Supérieure des Mines de Saint-Etienne, CIS-EMSE, SAINBIOSE, Saint Etienne, France. 2INSERM U1059, SAINBIOSE, Saint Etienne, France. 3Université de Lyon, Lyon, France. 4Laboratoire Sols-Solides-Structures-Risques (3SR), CNRS/Université de Grenoble (Grenoble INP-UJF), Grenoble, France. 5CHU Hôpital Nord, Saint Etienne, France.
O0454 Fibrous Architecture of the Aortic Valve Aids in Leaflet Mechanics and Hemodynamics Dorma Carl Flemister1, Lakshmi Prasad Dasi1, Jayanthi Parthasarathy2, Brad Hoehne2
1The Ohio State Universty, Columbus, USA. 2Nationwide Children's Hospital, Columbus, USA.
O0456 Evaluation of WIAMan biofidelity during explosive-driven vertical acceleration David Barnes1, Kerry A. Danelson2, Aaron Alai1, Andrew R. Kemper3, Danielle Cristino3, Matthew J. Mason3, Jason Tice4, Patricia Frounfelker4, John H. Bolte, IV5, Warren N. Hardy3
1SURVICE Engineering Company, Belcamp, MD, USA. 2Wake Forest School of Medicine, Department of Orthopaedics, Winston-Salem, NC, USA. 3Virginia Tech, Center for Injury Biomechanics, Blacksburg, VA, USA. 4U.S. Army Research Laboratory, Aberdeen Proving Ground, MD, USA. 5The Ohio State University, Injury Biomechanics Research Center, Columbus, OH, USA.
O0458 Influence of helmet pads in a ballistically-driven blunt impact Karin Rafaels1, Kathryn Loftis1, Nitin Moholkar2, Patrick Gillich1
1United States Army Research Laboratory, APG, MD, USA. 2Altus Engineering, APG, MD, USA.
O0459 Mechanical Properties of Human Skin under Dynamic Indentation Test Kevin Kong, Jason Forman, Matthew B. Panzer
Center for Applied Biomechanics, University of Virginia, Charlottesville, USA.
O0460 Occupant Response to Underbody Blast Kyvory Henderson1, E.Meade Spratley1, Constantine Demetropoulos2, Aaron Alai3, Frederick Hughes3, Robert Salzar1
1University of Virginia Center for Applied Biomechanics, Charlottesville, USA. 2Johns Hopkins Applied Physics Laboratory, Laurel, USA. 3Army Research Laboratory, Aberdeen, USA.
O0461 Influence of Seating Environment on PMHS Response in Physically Simulated Underbody Blast Exposure Constantine Demetropoulos1, Kyle Ott1, Christopher Dooley1, Nathanael Kuo1, Leah Strohsnitter1, Joseph Andrist1, Mary Luongo1, David Drewry1, Andrew Merkle1, Jonathan Rupp2, Lauren Wood Zaseck3, Anne Bonifas3, Carl Miller3, Nichole Ritchie Orton3, Matthew Reed3
1The John Hopkins University Applied Physics Laboratory, Laurel, USA. 2Emory University, Atlanta, USA. 3The University of Michigan, Ann Arbor, USA.
O0462 Male and Female Lumbar Spinal Column Human Injury Probability Curves under vertical Impact Narayan Yoganandan1, Jason Moore2, Frank Pintar1, Jiangyue Zhang3
1MEDICAL COLLEGE OF WISCONSIN, MILWAUKEE, USA. 2Medical College of Wisconsin, M, USA. 3Johns Hopkins University, Laurel, USA.
O0463 Do blast-induced skull flexures result in axonal deformation? Harsha Garimella1, Reuben Kraft2
1CFDRC, Inc., Huntsville, USA. 2Pennsylvania State University, University Park, USA.
O0464 Novel severity measures link fractures from cadaveric experiments to those in battlefield blast cases Kevin N. Dibbern1, Brandon J. Perry2, Edward M. Spratley2, Robert S. Salzar2, Jessica C. Rivera3, Donald D. Anderson1
1University of Iowa, Iowa City, Iowa, USA. 2University of Virginia, Charlottesville, Virginia, USA. 3U.S. Army Institute of Surgical Research, San Antonio, Texas, USA.
O0468 IN Silico trials for treatment of acute Ischemic Stroke (INSIST) Praneeta Konduri1,2, Ed van Bavel1, Aad van der Lugt3, Bastien Chopard4, Laurian Jongejan5,6, Stephen Payne7, Alfons Hoekstra8, Patrick McGarry9, Henk Marquering1,2, Charles Majoie2
1Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands. 2Department of Radiology and Nuclear Medicine, Academic Medical Center, Amsterdam, Netherlands. 3Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, Netherlands. 4Computer Science Department, Universite de Geneve, Geneve, Switzerland. 5Center of Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, Netherlands. 6Experimental Immunology, Academic Medical Center, Amsterdam, Netherlands. 7Engineering Science, Institute of Biomedical Engineering, The Chancellor, Masters and Scholars of the University of Oxford, Oxford, United Kingdom. 8Institute of Informatics, Faculty of Science, Universiteit van Amsterdam, Amsterdam, Netherlands. 9Biomedical Engineering, National University of Ireland, Galway, Ireland.
O0469 Experimental and computational analysis of the mechanical behaviour of thrombus material Sarah Johnson1, Michael Gilvarry2, Patrick McGarry1, Peter McHugh1
1National University of Ireland Galway, Galway, Ireland. 2Neuravi Ltd., Galway, Ireland.
O0470 Characterisation of Strut Indentation during Mechanical Thrombectomy in Acute Ischemic Stroke Clot Analogues Fiona Weafer1,2, Sharon Duffy2, Ines Machado3, Gillian Gunning2, Pasquale Mordasini4, Ellen Roche1, Peter McHugh1, Michael Gilvarry2
1College of Engineering and Informatics, National University of Ireland, Galway, Ireland. 2Neuravi Thromboembolic Initative, Neuravi Ltd, Galway, Ireland. 3Instituto Superior Tecnico, Universidade de Lisboa, Lisbon, Portugal. 4Department of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland.
O0472 Biomechanical Simulations of Progressing Osteoarthritis: Experiments, Theory, Finite Elements, and Preliminary Results David M. Pierce1, Franz Maier1, Borja Rodriguez‑Vila2, Thomas S.E. Eriksson3, Tim Ricken4, Courtland G. Lewis5
1University of Connecticut, Storrs, USA. 2Universidad Europea de Madrid, Madrid, Spain. 3FOI – Swedish Defence Research Agency, Stockholm, Spain. 4Universität Stuttgart, Stuttgart, USA. 5Hartford Healthcare, Hartford, USA.
O0473 Growth and remodeling of human aortic and pulmonary heart valves Sandra Loerakker1, Pim Oomen1, Tommaso Ristori1, Maria Holland2, Ellen Kuhl2, Frank Baaijens1, Carlijn Bouten1
1Eindhoven University of Technology, Eindhoven, Netherlands. 2Stanford University, Stanford, USA.
O0475 Predicting angiogenesis using bone fracture healing outcomes in an in vivo mouse femur defect model. Matthias Graß, Duncan C. Betts, Angad Malhotra, Ralph Müller
Institute for Biomechanics, ETH Zurich, Zurich, Switzerland.
O0476 How does a transcondylar screw enhance healing of subchondral bone cysts? Lance Frazer1, Elizabeth Santschi2, Kenneth Fischer1
1University of Kansas, Lawrence, USA. 2Kansas State University, Manhattan, USA.
O0477 Quantitative computational model of sex hormone effects on tissue remodeling agents after knee injury Bethany Powell1, David Malaspina2, Igal Szleifer1, Yasin Dhaher1
1Northwestern University, Evanston, USA. 2Institut de Ciencia de Materials de Barcelona, Barcelona, Spain.
O0478 Improving bone ingrowth in additive manufactured porous implants using novel adaptive algorithms incorporating osteoconductivity: an experimental and finite element study Vee San Cheong1,2, Paul Fromme2, Aadil Mumith1, Melanie Coathup1, Gordon Blunn1,3
1Institute of Orthopaedics and Musculoskeletal Sciences, University College London, Stanmore, United Kingdom. 2Department of Mechanical Engineering, University College London, London, United Kingdom. 3School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom.
O0479 Load carriage mass and walking speed alter medial compartment knee joint contact forces in soldiers Gavin K Lenton1, Tim LA Doyle2, David G Lloyd1, Peter J Bishop1, Dan Billing3, David J Saxby1
11Gold Coast Orthopaedics Research and Education Alliance, Menzies Health Institute Queensland, Griffith University. 2School of Allied Health Sciences, Griffith University., Gold Coast, Australia. 2Department of Health Professions, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Australia. 3Defence Science and Technology Group, Fisherman's Bend, Australia.
O0480 Quantitative analysis of the stand to sit pelvis kinematics using 3D reconstructions from bi-planar x-rays François Girinon1, Youngwoo Kim1,2, Jean-Yves Lazennec2, Wafa Skalli1
1Institut de Biomecanique Humaine Georges Charpak, Arts et Metiers ParisTech, Paris, France. 2Department of Orthopaedic and Trauma Surgery, Pitié-Salpêtrière Hospital, Assistance Publique–Hôpitaux de Paris, Paris, France.
O0482 Calibration of neuromuscular parameters affects estimation of hip joint contact forces in healthy adults Hoang Hoa1,2, Diamond Laura1,2, Lloyd David1,2, Pizzolato Claudio1,2
1Gold Coast Orthopaedics Research and Education Alliance, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia. 2School of Allied Health Sciences, Griffith University, Gold Coast, Queensland, Australia.
O0483 Validation of a multi-objective optimisation for the estimation of the musculo-tendon, ligament, and joint contact forces during gait Raphael Dumas1, Laurence Cheze1, Florent Moissenet2
1Univ Lyon, Université Claude Bernard Lyon 1, IFSTTAR, LBMC UMR_T9406, Lyon, France. 2Centre National de Rééducation Fonctionnelle et de Réadaptation – Rehazenter, Laboratoire d’Analyse du Mouvement et de la Posture (LAMP), Luxembourg, Luxembourg.
O0484 Preliminary comparison of EOS-derived and geometrically calibrated segment lengths: inter-hip and femur cases Pierre Puchaud1,2, Christophe Sauret3, Antoine Muller2, Hélène Pillet4, Nicolas Bideau5, Georges Dumont6, Charles Pontonnier1,2
1CREC, Ecoles de St-Cyr Coëtquidan, Guer, France. 2Univ Rennes, Inria, CNRS, IRISA, M2S, Rennes, France. 3Institut de Biomécanique Humain Georges Charpak, Arts et Métier ParisTech, Paris, France. 4Institut de Biomécanique Humaine Georges Charpak, Arts et Métier ParisTech, Paris, France. 5Univ Rennes, M2S, Rennes, France. 6Univ Rennes, Inria, CNRS, IRISA , M2S, Rennes, France.
O0485 Knee contact loading differences during over ground and treadmill gait Kate Jones1, Sam Van Rossom2, Ilse Jonkers2, Robert van Deursen1
1Cardiff University, Cardiff, United Kingdom. 2K.U. Leuven, Leuven, Belgium.
O0487 Plantarflexor strength deficits at 12 weeks post-surgery do not influence plantarflexor moments during gait in patients with Achilles tendon rupture Alison Agres1, William Taylor2, Tobias Gehlen3, Adamantios Arampatzis4, Sebastian Manegold3, Georg Duda1
1Julius Wolff Institute, Charité, Berlin, Germany. 2Institute of Biomechanics, ETH Zürich, Zürich, Switzerland. 3Center for Musculoskeletal Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany. 4Dept. for Training and Movement Science, Humboldt University of Berlin, Berlin, Germany.
O0488 A microfluidic model of endothelial metabolism in flow Swathi Swaminathan, Sarah Basehore, Alisa Clyne
Drexel University, Philadelphia, USA.
O0490 3D model of Human Blood-Brain Barrier Microvascular Network including iPS-derived Endothelial Cells, brain Pericytes and Astrocytes Marco Campisi1, Yoojin Shin2, Tatsuya Osaki2, Valeria Chiono3, Roger Kamm2,4
1Department of Mechanical and Aerospace Engineering, politecnico di Torino, Turin, Italy. 2Department of Mechanical engineering, Massachusetts Institute of Technology, Cambridge, USA. 3Department of Mechanical and Aerospace Engineering,politecnico di Torino, Turin, Italy. 4Department of Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA.
O0491 A loss of vascular endothelial barrier function by hypoxic exposure Kenichi Funamoto, Yugo Tabata, Rei Koens, Daisuke Yoshino
Tohoku University, Sendai, Japan.
O0492 Quantitative dynamics of red blood cells passing through biomimetic submicron splenic slits Priya Gambhire1, Alexis Moreau1, Scott Atwell1, Cecile Iss1, Huijie Lu2, Catherine Badens3, Zhangli Peng2, Emmanuèle Helfer1, Annie Viallat1, Anne Charrier1
1CINaM, CNRS, Aix Marseille University, Marseille, France. 2Notre Dame University, Southband, USA. 3Aix Marseille Univ, INSERM, GMGF, Marseille, France.
O0494 A microfluidic platform for high-throughput drug screening on 3D functional microtissues Roberta Visone, Giovanni Stefano Ugolini, Alberto Redaelli, Marco Rasponi
Politecnico di Milano, Milan, Italy.
O0495 Laboratory based quantitative outcome assessment in orthopaedic trials Peter Augat,
Berufsgenossenschaftliche Unfallklinik Murnau, Murnau, Germany. Paracelsus Medical University, Salzburg, Austria.
O0497 Early weight bearing capacity predicts healing outcome after tibia fracture Inga Kröger, Janina Müßig, Robert Pätzold, Isabella Klöpfer-Krämer, Andreas Brand, Hannes Wackerle, Peter Augat
Trauma Center Murnau, Murnau, Germany.
O0498 The AO Fracture monitor Markus Windolf, Manuela Ernst, Dominic Gehweiler, Viktor Varjas, Ronald Schwyn, Geoff Richards, Boyko Gueorguiev
AO Research Institute Davos, Davos, Switzerland.
O0499 Dynamic pedobarographic outcome assessment after geriatric, intertrochanteric femur fractures – Results using a novel monitoring device Benedikt Braun, David Osche, Marcel Orth, Sina Heimueller, Mika Rollmann, Moritz Klein, Steven Herath, Tim Pohlemann
Saarland University Hospital; Trauma Department, Homburg, Germany.
O0500 The use of a wrist-worn accelerometer to objectively measure activity and sleep parameters in patients following total hip arthroplasty. Jasvir Bahl1, John Arnold1, Francois Fraysse1, Lucian Bogdan Solomon2,3, Dominic Thewlis2
1Alliance for Research in Exercise, Nutrition and Activity, University of South Australia, Adelaide, Australia. 2Centre for Orthopaedic & Trauma Research, University of Adelaide, Adelaide, Australia. 3Dept. of Orthopaedics and Trauma, Royal Adelaide Hospital, Adelaide, Australia.
O0502 The effect of cement augmentation on pedicle screw fixation under various load cases: results from a combined experimental, micro-CT and micro finite element analysis Yan Chevalier1, Maiko Matsuura1, Sven Krueger2, Hannes Traxler3, Christoph Fleege4, Michael Rauschmann4, Christoph Schilling2
1Ludwig Maximilians University Munich, Munich, Germany. 2Aesculap AG, Tuttlingen, Germany. 3Medical University of Vienna, Vienna, Austria. 4Orthopädische Universitätsklinik Friedrichsheim GmbH, Frankfurt am Main, Germany.
O0503 Experimental analysis of the lower cervical spine in hyperflexion Christophe Muth-seng1, David Brauge1,2,3, Nicolas Soriau1, Baptiste Sandoz1, Maxim Van den Abbeele1, Wafa Skalli1, Sebastien Laporte1
1Arts et Métiers Paristech, Institut de Biomécanique Humaine George Charpak, Paris, France. 2Pôle Neuroscience-Neurochirurgie, Hôpital de Purpan, Toulouse, France. 3Université Paul Sabatier, Toulouse, France.
O0506 Which material properties and which morphology parameters are most important for numerical models of the lumbar spine? Benedikt Schlager1, Frank Niemeyer1, Fabio Galbusera1,2, David Volkheimer1, Rene Jonas1, Hans-Joachim Wilke1
1Institute of Orthopaedic Research and Biomechanics, Ulm, Germany. 22. IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
O0507 Biomechanical testing of a PCU-based dynamic instrumentation device under physiological conditions. Agnes Beckmann1, Luis Nicolini,1, Christian Herren,2, David Grevenstein3, Stavros Oikonomidis3, Marcus Stoffel1, Bernd Markert1, Jan Siewe3
1Institute of General Mechanics, RWTH Technical University of Aachen, Aachen, Germany. 2Department for Trauma and Re- constructive Surgery, Aachen University Hospital, Aachen, Germany. 3Centre for Orthopedic and Trauma Surgery, University Hospital of Cologne, Cologne, Germany.
O0508 Postural modifications with lung volume variations Louis Clavel1,2, Baptiste Sandoz1, Ségolène Rémy-Néris2, Olivier Jacq2,3, Philippe Rouch1, Thomas Similowski2,3, Wafa Skalli1, Valérie Attali1,2,3
1Arts et Metiers ParisTech, Institut de Biomecanique Humaine Georges Charpak, Paris, France. 2UMRS1158 Neurophysiologie respiratoire expérimentale et Clinique, Sorbonne Universités, INSERM, UPMC, Paris, France. 3Département “RS3”, F-75013, Groupe Hospitalier Pitié-Salpêtrière Charles Fois, Paris, France.
O0509 Influence of osteophytes and regional microstructural heterogeneity on BMD and TBS in human thoracic vertebrae Annika vom Scheidt1, Petar Milovanovic1,2, Eric Flavio Grisolia Seifert1, Carolin Pokrant1, Michael Amling1, Klaus Püschel1, Björn Busse1
1University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 2University of Belgrade, Belgrade, Serbia.
O0510 Vertebral fractures in the neoplastic spine: a finite element investigation Fabio Galbusera1, Tito Bassani1, Gloria Casaroli1, Zhihui Qian2, Benedikt Schlager3, Hans-Joachim Wilke3
1IRCCS Istituto Ortopedico Galeazzi, Milan, Italy. 2Jilin University, Changchun, China. 3Ulm University, Ulm, Germany.
O0514 A population-based principal component analysis of patellofemoral morphology and quadriceps forces on joint contact Justin Fernandez1,2, Sharon Zhu1, Thor Besier1,2, Ju Zhang1
1Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand. 2Department of Engineering Science, University of Auckland, Auckland, New Zealand.
O0515 In vivo tibia deformation regimes and strain distribution in humans during different locomotive activities Peng-Fei Yang1,2, Andreas Kriechbaumer3, Maximilian Sanno4, Bergita Ganse3, Timmo Koy5, Gert-Peter Brüggemann4, Lars Peter Müller5, Jörn Rittweger3
1Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, China. 2Research & Development Institute in Shenzhen, Northwestern Polytechnical University, Xi'an, China. 3Division Muscle & Bone Metabolism, Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany. 4Institute of Biomechanics and Orthopaedics, German Sport University Cologne, Cologne, Germany. 5Department of Orthopaedic and Trauma Surgery, University of Cologne, Cologne, Germany.
O0516 Statistical parametric mapping of hip contact forces in total hip replacement patients stratified by BMI Enrico De Pieri1, David Lunn2, Kasper Rasmussen3, Anthony Redmond2, Stephen Ferguson1
1ETH Zurich, Zurich, Switzerland. 2Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom. 3AnyBody Technology A/S, Aalborg, Denmark.
O0517 An update on the CAMS-Knee Dataset: A Key Dataset for the Comprehensive Assessment of the Musculoskeletal System William R. Taylor1, Pascal Schütz1, Barbara Postolka1, Jörn Dymke2, Verena Schwachmeyer2, Marco Hitz1, Renate List1, Philipp Damm2
1Institute for Biomechanics, ETH Zürich, Zürich, Switzerland. 2Julius Wolff Institute, Charité - Universitätsmedizin Berlin, Berlin, Germany.
O0520 Spatio-temporal analysis of megakaryocyte elongation during platelet production Ilyesse Bihi1, Sonia Poirault-Chassac2, Meryem Lebsir2, Mathilde Reyssat3, Dominique Baruch2, Anne Le Goff1
1Sorbonne Universités, Université de Technologie de Compiègne, UMR CNRS 7338 Biomécanique et Bioingénierie,, Compiegne, France. 2INSERM UMR 1140, Université Paris Descartes, Sorbonne Paris Cité,, Paris, France. 3CNRS UMR 7083 Gulliver, ESPCI,, Paris, France.
O0522 The role of actomyosin contractility on giant vacuole biomechanics in cultured Schlemm’s canal endothelial cells Alice Spenlehauer1, Joseph M. Sherwood1, William D. Stamer2, Chiu Fan Lee1, Darryl R. Overby1
1Imperial College London, London, United Kingdom. 2Duke University, Durham, USA.
O0523 Manipulation of primary cilia mechanotransduction Liam Boyle1,2, Damien Lacroix1,3, Gwendolen Reilly1,2
1INSIGNEO institute for in silico medicine, University of Sheffield, Sheffield, United Kingdom. 2Department of Materials Science and Engineering, University of Sheffield, Sheffield, United Kingdom. 3Department of Mechanical Engineering, University of Sheffield, Sheffield, United Kingdom.
O0524 Microfluidic-integrated microclot array elastometry (clotMAT) to study blood clot micromechanics Zhaowei Chen, Jiankai Lu, Changjie Zhang, Isaac Hsia, Sriram Neelamegham, Ruogang Zhao
State University of New York at Buffalo, Buffalo, NY, USA.
O0525 25 years of physiome: the clinical translation and the Virtual Physiological Human Marco Viceconti,
Insigneo Institute for in silico Medicine, Sheffield, United Kingdom. Department of Mechanical Engineering, University of Sheffield, Sheffield, United Kingdom.
O0529 Model semantics for discovery, composition, and personalisation David Nickerson, Koray Atalag, Reza Kalbasi, Dewan Sarwar, Tommy Yu, Peter Hunter
Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
O0531 Quantitative T1rho measurement of gliomas Toshiaki Akashi1, Hitoshi Nemoto1, Makoto Obara2, Hiroki Kamata1, Shiho Sato1, Kei Takase1
1Tohoku University Hospital, Sendai, Japan. 2Philips Healthcare Japan, Tokyo, Japan.
O0532 Comparison of skin thickness measurement by magnetic resonance, histologic procedure and biopsy freezing Jesica Isaza, Manuela Jaramillo, Melisa Cardona, Juan Ramirez
Universidad Nacional de Colombia, Medellin, Colombia.
O0533 T1ρ Relaxation Modeling via the Stretched Exponential in the Intervertebral Disc Robert Wilson1, Leah Bowen1, Luyao Cai2, Woong Kim2, David Reiter3, Corey Neu1
1University of Colorado, Boulder, USA. 2Purdue University, West Lafayette, USA. 3Emory University, Atlanta, USA.
O0534 Minimum inter-limb difference of tri-compartment knee cartilage T2 values in healthy subjects Jack R. Williams1, Ashutosh Khandha2, Kelsey Neal1, Lynn Snyder-Mackler3, Thomas S Buchanan1
1Mechanical Engineering, University of Delaware, Newark, USA. 2Biomechanics and Movement Science, University of Delaware, Newark, USA. 3Physical Therapy, University of Delaware, Newark, USA.
O0536 Evaluation of bone collagen fibril three-dimensional orientation in nano-CT images using a refined autocorrelation-based method. Daniel Fiole1,2, Boliang Yu1, Alexandra Pacureanu2, Peter Varga3, Cécile Olivier1,2, Pierre-Jean Gouttenoire1,2, Max Langer1, Peter Cloetens2, Françoise Peyrin1,2
1Univ Lyon, CNRS UMR 5220, Inserm U1206, INSA Lyon, Université Claude Bernard Lyon 1, Creatis, Villeurbanne, France. 2European Synchrotron Radiation Facility, Grenoble, France. 3AO Research Institute Davos, Davos, Switzerland.
O0537 Activity Microscopy: Extracting network mechanics from thermal noise Emanuel L Lissek1, Tobias F Bartsch2, Ernst-Ludwig Florin1
1University of Texas at Austin, Austin, TX, USA. 2The Rockefeller University, New York, NY, USA.
O0538 Application of co-occurrence texture statistics analysis of thermogram as a model of the muscle activity Malgorzata Masko1, Malgorzata Domino2, Lukasz Zdrojkowski2, Marta Borowska3, Edward Oczeretko3, Zdzislaw Gajewski2
1Department of Animal Breeding, Faculty of Animal Science, WULS – SGGW, Warszawa, Poland. 2Department of Large Animal Diseases with Clinic, Veterinary Research Centre and Center for Biomedical Research Faculty of Veterinary Medicine, WULS – SGGW, Warszawa, Poland. 3Bialystok University of Technology, Bialystok, Poland.
O0539 A novel automated method for a real-time behavioral pattern analysis of primate using a depth image sensor Sang Kuy Han1, Yejoon Rim2, Manhyung Han2, Keonwoo Kim3,4, Youngjeon Lee3, Philyong Kang3, Yeung Bae Jin3, Jungwha Hong5, Keyoung Jin Chun1, Sang Rae Lee3
1Korea Institute of Industrial Technology, Cheoan, Korea, Republic of. 2Kinetic Lab Inc., Pangyo, Korea, Republic of. 3Korea Research Institute of Bioscience and Biotechnology, Cheongju, Korea, Republic of. 4Inje Universiy, Gimhae, Korea, Republic of. 5Korea University, Sejong, Korea, Republic of.
O0541 Retention of seeded mesenchymal stem cells within an implanted elastomeric vascular scaffold David Vorp1,2,3, Katherine Lorentz1,4, Darren Haskett3, Justin Weinbaum1,4, Antonio D'Amore4, William Wagner1,3,4
1University of Pittsburgh Department of Bioengineering, Pittsburgh, USA. 2University of Pittsburgh Department of Cardiothoracic Surgery, Pittsburgh, USA. 3University of Pittsburgh Department of Sugery, Pittsburgh, USA. 4University of Pittsburgh McGowan Institute for Regenerative Medicine, Pittsburgh, USA.
O0542 Physiologic flow reduces pathologic indications of microvessels cultured in vitro Kristina Haase1, Roberta Visone2,1, Roger Kamm1,3
1Massachusetts Institute of Technology, Cambridge, USA. 2Politecnico di Milano, Milan, Italy. 3Singapore MIT Alliance for Research & Technology, Singapore, Singapore.
O0543 Vascular Redundancy and Damage Tolerance in Microvascular Networks Gabriel Gruionu1, James Baish2, Lucian Gruionu3, Despina Bazou1, Mara Onita-Lenco1, Sean McMahon2, Nir Maimon1, Lance Munn1
1Harvard Medical School and Massachusetts General Hospital, Boston, USA. 2Bucknell University, Lewisburg, PA, USA. 3University of Craiova, Craiova, Romania.
O0544 Effect of age on biomechanics of in situ engineered small diameter vascular grafts Piyusha Gade1, Keewon Lee1, Yadong Wang2, Anne Robertson1,3,4
1Department of Bioengineering, University of Pittsburgh, Pittsburgh, USA. 2Meinig School of Biomedical Engineering, Cornell University, Ithaca, USA. 3Department of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, USA. 4McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, USA.
O0545 Computational modeling of the inflammatory response to implanted polymeric scaffolds to improve tissue engineering of vascular grafts Jason Szafron1, Ramak Khosravi1, Abhay Bangalore Ramachandra1, James Reinhardt2, Cameron Best2, Christopher Breuer2, Alison Marsden3, Jay Humphrey1
1Department of Biomedical Engineering, Yale University, New Haven, CT, USA. 2Tissue Engineering Program, Nationwide Children's Hospital, Columbus, OH, USA. 3Department of Pediatrics (Cardiology), Bioengineering, and ICME, Stanford University, Stanford, CA, USA.
O0546 Arteriole-Scale Human Tissue-Engineered Blood Vessel Models of Healthy and Disease States George Truskey1, Leigh Atchison1, Cristina Fernandez1, Xu Zhang1, Thomas Povsic2
1Duke University, Durham, USA. 2Duke University Medical Center, Durham, USA.
O0547 Nanoscale architecture of cadherin-based cell adhesions Pakorn Kanchanawong,
Mechanobiology Institute, National University of Singapore, 117411, Singapore. Department of Biomedical Engineering, National University of Singapore, 117411, Singapore.
O0548 Mechanics of cell contacts during tissue morphogenesis Pruthvi C. Shivakumar, Eunice H.Y. Chan, Raphaël Clément, Pierre-François Lenne
Aix Marseille Univ, CNRS, IBDM, Marseille, France.
O0550 Mechanics of chromatin in situ Daniel Whitefield1, Travis Armiger1, Li Lan2, Kris Dahl1
1Carnegie Mellon University, Pittsburgh, USA. 2University of Pittsburgh, Pittsburgh, USA.
O0551 Optimal number of SNARE proteins for fast neurotransmetter release Fabio Manca1, Frédéric Pincet1,2,3, Lev Truskinovsky4, James E. Rothman2,3, Lionel Foret1, Matthieu Caruel5
1Laboratoire de Physique Statistique, Ecole Normale Supérieure, CNRS-UMR 8550, Paris, France. 2Department of Cell Biology, School of Medicine, Yale University, New Haven, USA. 3Nanobiology Institute, School of Medicine, Yale University, New Haven, USA. 4PMMH, CNRS UMR 7636, ESPCI, PSL, Paris, France. 5Université Paris Est, Laboratoire Modélisation et Simulation Multi Echelle, MSME-UMR-CNRS-8208, Créteil, France.
O0553 In situ measurement of membrane mechanical moduli using fluorescence lifetime distribution of DiI Seoyoung Son, Hari Muddana, Changjin Huang, Sulin Zhang, Peter Butler
The Pennsylvania State University, University Park, USA.
O0555 Evaluating and interpreting patient-specific neuromuscular control in cerebral palsy Katherine Steele1, Benjamin Shuman1, Marije Goudriaan2,3, Kaat Desloovere2,3, Michael Schwartz4,5
1University of Washington, Seattle, USA. 2KU Leuven, Leuven, Belgium. 3University Hospitals Leuven, Pellenberg, Belgium. 4Gillette Children's Specialty Healthcare, St. Paul, USA. 5University of Minnesota, Minneapolis, USA.
O0557 Changes in muscle synergy weights and activations after Botulinum toxin injections are not related to targeted muscles in children with cerebral palsy. Benjmain Shuman1, Marije Goudriaan2,3, Kaat Desloovere2,3, Michael Schwartz4,5, Kathrine Steele1
1University of Washington, Department of Mechanical Engineering, Seattle, USA. 2KU Leuven, Department of Rehabilitation Science, Leuven, Belgium. 3Clinical Motion Analysis Laboratory, University Hospitals Leuven, Pellenberg, Belgium. 4James R. Gage Center for Gait & Motion Analysis, Gillette Children’s Specialty, St. Paul, USA. 5University of Minnesota, Department of Biomedical Engineering, Minneapolis, USA.
O0558 Neuromuscular Control Changes in Response to Biofeedback on Gait in Children with Cerebral Palsy Adam Booth1,2, Annemieke Buizer1, Frans Steenbrink2, Jaap Harlaar1, Marjolein van der Krogt1
1VU University Medical Center, Amsterdam, Netherlands. 2Motek, Amsterdam, Netherlands.
O0559 Quantifying the separate effects of Botulinum Toxin-A and lower leg casting on ankle joint hyper-resistance in children with cerebral palsy. Lynn Bar-On1,2, Britta Hanssen1, Simon Schless1, Nicky Peeters1, Anja Van Campenhout1, Kaat Desloovere1
1KU Leuven, Leuven, Belgium. 2VU medical center, Amsterdam, Netherlands.
O0560 Investigating cerebral palsy using EMG-informed approaches: a twin case study Giorgio Davico1,2, Claudio Pizzolato1,2, Steven J Obst3, David G Lloyd1,2, Christopher P Carty1,2,4
1Gold Coast Orthopaedics Research and Education Alliance, Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia. 2School of Allied Health Sciences, Griffith University, Gold Coast, Australia. 3School of Health, Medical and Applied Sciences, Central Queensland University, Bundaberg, Australia. 4Queensland Children’s Motion Analysis Service, Children’s Health Queensland, Brisbane, Australia.
O0561 Computation of postural parameters during gait in children with cerebral palsy and typically developing children using a subject-specific skeletal registration technique Ayman Assi1,2, Abir Massaad1, Tristan Hermel2, Fares Yared1, Joeffroy Otayek1, Aren Joe Bizdikian1, Ziad Bakouny1, Nour Khalil1, Ismat Ghanem1, Xavier Bonnet2, Helene Pillet2, Wafa Skalli2
1Faculty of Medicine, University of Saint-Joseph, Beirut, Lebanon. 2Institut de Biomécanique Humaine Georges Charpak, Arts et Métiers ParisTech, Paris, Lebanon.
O0562 Cellular response to changes in interfacial energy at the alveolar level Daniel ISABEY1,2,3, Sofia ANDRE DIAS2, Emmanuelle PLANUS4, Christelle ANGELY2, Gabriel PELLE2, Bruno LOUIS2,1,3, Marcel FILOCHE2,1,5
1CNRS, CRETEIL, France. 2Inserm, CRETEIL, France. 3Université Paris Est, CRETEIL, France. 4Université Grenoble Alpes, Grenoble, France. 5Ecole Polytechnique, Palaiseau, France.
O0564 Interactions between organs via the autonomic nervous system Peter Hunter, David Nickerson, Bernard de Bono
Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
O0565 Hierarchical modeling of the heart within the circulation and cardiopulmonary systems Dominique Chapelle,
Inria, Université Paris-Saclay, Palaiseau, France. LMS, Ecole Polytechnique, CNRS, Université Paris-Saclay, Palaiseau, France.
O0566 Finite element model of work of breathing in six year old children David Wootton1, Michel Behr2,3
1The Cooper Union, New York, USA. 2Aix-Marseille Université, Marseille, France. 3Laboratoire de Biomécanique Appliquée, IFSTTAR, Marseille, France.
O0567 Examination of left ventricular inter-constituent mechanical interaction and its effect on residual stress Marissa Grobbel, Sheikh Mohammad Shavik, Emma Darios, Stephanie Watts, Lik Chuan Lee, Sara Roccabianca
Michigan State University, East Lansing, USA.
O0570 Regulating Redundant Mechanical and Thermal Sensitization Pathways in Discogenic Pain Josh Stover, Corban Bothell, Jared Zitnay, Brandon Lawrence, Jeffrey Weiss, Robby Bowles
University of Utah, Salt Lake City, USA.
O0571 Multiscale Deformation Behavior of Nucleus Pulposus Cells in Pro-inflammatory Conditions Quynhhoa Nguyen1, Andrew Wong2, John Boyle1, Nadeen Chahine1
1Columbia University, New York, USA. 2Feinstein Institute for Medical Research, Manhasset, USA.
O0573 Development and Validation of a High-throughput Bioreactor System for Studying Mechano-sensing within the Intervertebral disc Pavel Sul, Shirley Tang, Katherine Lakstins, Safdar Khan, William Marras, Benjamin Walter, Devina Purmessur
The Ohio State University, Columbus, USA.
O0574 Mechanosensing of Tendon Fatigue Damage: Role of Altered Collagen Organization versus Altered Tissue Mechanics Spencer Szczesny1,2, Tristan Driscoll2, Pen-Hsiu Chao3, Robert Mauck2
1Pennsylvania State University, University Park, USA. 2University of Pennsylvania, Philadelphia, USA. 3National Taiwan University, Taipei, Taiwan.
O0575 Biomechanics of the human ulnar nerve: a comparison between in situ and in vitro strains Carla Barberio1, Tahseen Chaudhry2, Dominic Power2, Simon Tan2, Bernard Lawless3, Daniel Espino3, Joanne Wilton1
1Department of Anatomy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom. 2Hand & Peripheral Nerve Research Network, Birmingham Hand Centre, Queen Elizabeth University Hospital Birmingham, Birmingham, United Kingdom. 3Department of Mechanical Engineering, University of Birmingham, Birmingham, United Kingdom.
O0577 A novel apparatus for the multifaceted evaluation of human brachial artery functions through transmural pressure manipulation: Toward early-stage diagnosis of atherosclerosis Takeo Matsumoto1,2, Toshiyuki Yaguchi2,3, Yalin Cong2, Kenji Shimo2, Takahiro Kurokawa2, Shukei Sugita2, Kazuaki Nagayama2,4, Hiroshi Masuda5
1Nagoya University, Nagoya, Japan. 2Nagoya Institute of Technology, Nagoya, Japan. 3Tokyo Denki University, Hatoyama, Japan. 4Ibaraki University, Hitachi, Japan. 5UNEX Corporation, Nagoya, Japan.
O0578 Multi-Risk-Factor Decision-Making Strategy May Lead to Improved Coronary Plaque Burden Increase Prediction: A Patient-Specific 3D FSI Study Using IVUS Follow-Up Liang Wang1,2, Dalin Tang1,2, Akiko Maehara3, Zheyang Wu2, Chun Yang2, David Muccigrosso4, Jie Zheng4, Kristen Billiar5, Jian Zhu6, Genshan Ma6, Gary Mintz3
1School of Biological Science and Medical Engineering, Southeast University, Nanjing, China. 2Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, USA. 3Cardiovascular Research Foundation, New York, USA. 4Mallinckrodt Institute of Radiology, Washington University, St. Louis, USA. 5Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, USA. 6Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing, China.
O0580 Biomechanical Identification of Atherosclerotic Plaque Rupture Initiation and Propagation Ali Akyildiz1, Daniel Rutten2, Ronald van den Berg2, Frank Gijsen1
1Erasmus Medical Center, Rotterdam, Netherlands. 2Delft University of Technology, Delft, Netherlands.
O0581 On modelling patient-specific carotid atherosclerotic plaque formation and development Patricia Hernández1, Myriam Cilla2,3,4, Miguel A. Martínez1,4, Estefania Peña1,4
1Aragon Institute of Engineering Research, Mechanical Engineering Department. University of Zaragoza, Zaragoza, Spain. 2Centro Universitario de la Defensa. Academia General Militar, Zaragoza, Spain. 3Aragon Institute of Engineering Research. University of Zaragoza, Zaragoza, Spain. 4CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain, Zaragoza, Spain.
O0582 Plaque structural stress in the coronary atherosclerosis: a potential biomarker in predicting myocardial infarction Zhongzhao Teng1,2, Adam Brown3, Stephen Hoole4, Nick West4, Martin Bennett3, Jonathan G1
1Department of Radiology, University of Cambridge, Cambridge, United Kingdom. 2Department of Engineering, University of Cambridge, Cambridge, United Kingdom. 3Division of Cardiovascular Medicine, University of Cambridge, Cambridge, United Kingdom. 4Department of Interventional Cardiology, Papworth Hospital NHS Trust, Cambridge, United Kingdom.
O0583 Voxel size-dependency of a load-adaptive bone remodelling algorithm Nicholas Ohs1, Stephanie Sebastian1, Bert van Rietbergen2, Ralph Müller1, Patrik Christen1
1Institute for Biomechanics, ETH Zurich, Zurich, Switzerland. 2Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
O0584 A biphasic model of trabecular bone to predict the eletric field stimulation António Ramos, Marco Soares dos Santos, Jorge Ferreira, Maria Gomes
Biomechanics research Group, TEMA, University of Aveiro, Aveiro, Portugal.
O0585 Multiscale quantification of biomechanical roles of soft tissues for orthodontics Jingxiao Zhong1, Zhongpu Zhang1, Junning Chen2, Michael Swain1, Qing Li1
1University of Sydney, Sydney, Australia. 2Exeter University, Exeter, United Kingdom.
O0586 Including the Implant Degradation Process in a Fracture Healing Model Martin Pietsch1, Frank Niemeyer2, Karsten Urban3, Anita Ignatius2, Ulrich Simon1
1Scientific Computing Centre Ulm, Ulm, Germany. 2Institute of Orthopaedic Research and Biomechanics, Ulm, Germany. 3Institute for Numerical Mathematics, Ulm, Germany.
O0587 Post-operative bone remodeling and plastic damage in tibial bone Priyanka Srinivasan1, Mark Miller2, Nico Verdonschot1, Kenneth Mann2, Dennis Janssen1
1Radboud university medical center, Nijmegen, Netherlands. 2SUNY Upstate Medical University, Syracuse, USA.
O0589 An agent-based computer modeling approach to investigate the role of VEGFR1 in sprouting angiogenesis Clemens Kühn1, Georg N. Duda1,2, Sara Checa1
1Julius Wolff Institute, Charite Universitätsmedizin Berlin, Berlin, Germany. 2Berlin Brandenburg School of Regenerative Therapies, Berlin, Germany.
O0590 Mechanical Homeostasis in a Morphoelastic Mechanobiological Model of Airway Remodelling Michael Hill, Christopher Philp, Charlotte Billington, Amanda Tatler, Simon Johnson, Reuben O'Dea, Bindi Brook
University of Nottingham, Nottingham, United Kingdom.
O0595 A fast motor control framework for predictive simulation of musculoskeletal systems Reza Sharif Razavian, Borna Ghannadi, Valerie Norman-Gerum, John McPhee
University of Waterloo, Waterloo, Canada.
O0596 Estimation of human-exoskeleton collaborative movement Gil Serrancolí1,2, Antoine Falisse3, Christopher Dembia4, Joris De Schutter2, Friedl De Groote3
1Simulation and Movement Analysis Lab (SIMMA Lab), Department of Mechanical Engineering, Universitat Politècnica de Catalunya, Barcelona, Spain. 2Department of Mechanical Engineering, KU Leuven, Leuven, Belgium. 3Department of Movement Sciences, KU Leuven, Leuven, Belgium. 4Department of Mechanical Engineering, Stanford University, Stanford, CA, USA.
O0597 Contributions of the ankle passive moment increase to the compensatory adaptations in diabetic gait: a predictive simulation study Aline A. Gomes1,2, Gilmar F. Santos3, Marko Ackermann3, Isabel C. N. Sacco2
1Federal University of Amazonas, Physical Education and Physiotherapy Faculty, Manaus, Brazil. 2University of Sao Paulo, School of Medicine, Physical Therapy, Speech and Occupational Therapy Dept, Sao Paulo, Brazil. 3FEI University, Department of Mechanical Engineering, Sao Bernardo, Brazil.
O0598 Optimal control-based prediction of the influence of hip and lumbar flexibility on lifting motions Manish Sreenivasa1, Matthew Millard1, Idsart Kingma2, Jaap H. van Dieen2, Katja Mombaur1
1Optimization, Robotics & Biomechanics, Institute for Computer Engineering (ZITI), Heidelberg University, Heidelberg, Germany. 2Department of Human Movement Sciences, Vrije Universiteit, Amsterdam, Netherlands.
O0602 Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction Dennis Jones1, Eelco Meiijer1, Cedric Blatter1, Shan Liao2, Ethel Pereira1, Echoe Bouta1, Keehoon Jung1, Lance Munn1, Benjamin Vakoc1, Michael Otto3, Timothy Padera1
1Massachusetts General Hospital, Boston, MA, USA. 2University of Calgary, Calgary, AB, Canada. 3National Institutes of Health, Bethesda, MD, USA.
O0603 The relationship between lymphatic pump function and tissue swelling in lymphedema J. Brandon Dixon1, Tyler Nelson2, Matthew Cribb2, Mohammad Razavi2, Rudolph Gleason2
1Georgia Institute of Technology, Atlanta, Georgia. 2Georgia Institute of Technology, Atlanta, USA.
O0604 In vitro and Computational Modelling of the Eye for Evaluating the Delivery of Therapeutics in the Treatment of Retinal Pathologies Alys Davies1, Serban Pop2, Rachel Williams1, Victoria Kearns1
1Eye and Vision Science, University of Liverpool, Liverpool, United Kingdom. 2Computer Science, University of Chester, Chester, United Kingdom.
O0606 Improvement of screw anchorage by augmentation, from macroscopic to nanoscopic level Werner Schmoelz1, Alexander Keiler1, Raul Mayr1, Boyko Gueorguiev-Rüegg2, Michael Goetzen1
1Medical University of Innsbruck, Innsbruck, Austria. 2AO Research Institute, Davos, Switzerland.
O0607 Current Achievements in Hierarchical Bone Biomechanics - the Engineering Mechanics Perspective Christian Hellmich1, Stefan Scheiner1, Claire Morin2, Ales Kurfürst1
1TU Wien - Vienna University of Technology, Vienna, Austria. 2Ecole des Mines de Saint-Etienne, Saint-Etienne, France.
O0609 Finite element analysis on the effect of articular fracture lines for complex tibial plateau fractures Shabnam Samsami1,2, Robert Pätzold2,3,4, Sven Herrmann2, Martin Winkler2, Peter Augat2,3
1Faculty of Medicine, Ludwig Maximilian University of Munich (LMU), Munich, Germany. 2Institute of Biomechanics, Trauma Center Murnau, Murnau, Germany. 3Institute of Biomechanics, Paracelsus Medical University, Salzburg, Austria. 4Department of Trauma Surgery, Trauma Center Murnau, Murnau, Germany.
O0610 Hierarchical Elastoplasticity of Bone: Theory, Algorithm, and experimental Validation Valentina Wittner1, Claire Morin2, Christian Hellmich1
1Institute for Mechanics of Materials and Structures, Vienna University of Technology, Vienna, Austria. 2Ecole Nationale Supérieure des Mines, Saint-Étienne, France.
O0612 Antiangiogenic treatment improves tendon repair in a rat model Herbert Tempfer1,2, Alexandra Kaser-Eichberger1, Stefanie Korntner1, Christine Lehner1, Falk Schroedl1, Ludwig Heindl3, Andreas Traweger1,2
1Paracelsus Medical University, Salzburg, Austria. 2Austrian Cluster for Tissue Regneration, Vienna, Austria. 3University Eyeclinic Cologne, Cologne, Germany.
O0613 Investigation of cognitive stress induced changes in spinal disc forces due to altered kinematics and muscle activity. Franz Suess1,2, Simone Kubowitsch3, Gijsbertus J. Verkerke4,5, Sebastian Dendorfer1,2
1Ostbayerische Technische Hochschule (OTH) Regensburg, Laboratory for Biomechanics, Regensburg, Germany. 2Regensburg Center of Biomedical Engineering, OTH and University Regensburg, Regensburg, Germany. 3University of Regensburg, Institut für Sportwissenschaft, Regensburg, Germany. 4University of Groningen, University Medical Center Groningen (UMCG), Department of Rehabilitation Medicine, Groningen, Netherlands. 5University of Twente, Department of Biomechanical Engineering, Enschede, Netherlands.
O0614 The effects of vertebroplasty on regional load transfer to adjacent levels in cyclic loading Ines Santos1, Nicklas Hagenmayer1, Vanessa Pfahler2, Stefan Milz3, Bernd Wegener1, Christoph Birkenmaier1, Volkmar Jansson1, Yan Chevalier1
1Department of Orthopaedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich (LMU), Munich, Germany. 2Department of Radiology, University Hospital of Munich (LMU), Munich, Germany. 3Department of Anatomy, University Hospital of Munich (LMU), Munich, Germany.
O0616 How do morphological variations influence cervical spine range of motion in physiological loading? Jobin John1,2, Mike Arun2, Gurunathan Saravana Kumar1, Narayan Yoganandan2
1Indian Institute of Technology Madras, Chennai, India. 2Medical College of Wisconsin, Milwaukee, USA.
O0617 Fixation of the sacroiliac joint with posterior thoracolumbar instrumentation: an in silico investigation on four patients Gloria Casaroli1, Ruchi Chande2, Marco Brayda-Bruno1, Derek Lindsey2, Scott Yerby2, Fabio Galbusera1
1IRCCS Istituto Ortopedico Galeazzi, Milano, Italy. 2SI-BONE, Inc., San Jose (CA), USA.
O0618 Characterising human intervertebral discs at a range of strain rates using an inverse finite element approach Nicolas Newell1, Grigorios Grigoriadis1, Alexandros Christou1, Diagarajen Carpanen1, J Paige Little2, Spyros Masouros1
1Imperial College London, London, United Kingdom. 2Queensland University of Technology, Brisbane, Australia.
O0619 An energy approach to explore the spine balance in adolescent idiopathic scoliosis (AIS). Baptiste Brun-Cottan1, Roxane Compagnon1, Jérôme Sales de Gauzy2, Pauline Assemat1, Pascal Swider1
1Institut de Mécanique des Fluides de Toulouse, IMFT, Université de Toulouse, CNRS, Toulouse, France. 2Department of Pediatric Orthopedic Surgery, Children's Hospital, Toulouse, Toulouse, France.
O0624 Cyclic but not static loading increases bone mass in mouse caudal vertebrae Ariane Scheuren1, Angad Malhotra1, Gisela Kuhn1, Yoshitaka Kameo1,2, Ralph Müller1
1Institute for Biomechanics, ETH Zurich, Zurich, Switzerland. 2Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.
O0626 Osteoprogenitor YAP and TAZ combinatorially promote endochondral fracture repair Christopher Kegelman1, Hope Pearson2, James Dawahare2, Joel Boerckel1,2
1University of Pennsylvania, Philadelphia, USA. 2University of Notre Dame, Notre Dame, USA.
O0628 Mechanotransductive Promotion of Bone Tissue Regeneration in Critical Bone Defect byIn VivoFunctional Dynamic Fluid Flow Wonsae Lee1, Edison Sun2,3, Guoxian Feng1, Jian Yang4, Yi-Xian Qin1
1Stony Brook University, Stony Brook, USA. 2Longhua Hospital, Shanghai University of Chinese Traditional Medicine, Shanghai, China. 3Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. 4Penn State University, Old Main, USA.
O0630 Towards elucidating the role of the temporal gradient of wall shear stress in venous intimal hyperplasia development Marco Franzoni, David T. O'Connor, Michael T Walsh
Centre for Applied Biomedical Engineering Research, Health Research Institute, Bernal Institute, School of Engineering, University of Limerick, Limerick, Ireland.
O0631 The role of integrin αvβ3 in osteocyte mechanotransduction during estrogen deficiency Ivor Geoghegan1, David Hoey2, Laoise McNamara1
1NUI Galway, Galway, Ireland. 2Trinity College Dublin, Dublin, Ireland.
O0632 Characterization of the responsiveness of endothelial colony forming cells to flow Thévy Lok1,2, Nassim Arouche3, Georges Uzan3, Olaf Mercier2, Abdul Barakat1
1Hydrodynamics Laboratory (Ecole Polytechnique), Palaiseau, France. 2Marie Lannelongue Hospital, Le Plessis Robinson, France. 3Paul Brousse Hospital, Villejuif, France.
O0634 Binding kinetics and dynamic force spectrum for LFA-1 and Mac-1 to their ligands in neutrophil recruitment Ning Li1,2, Hao Yang1,2, Debin Mao1,2, Manliu Wang1,2, Shouqin Lü1,2, Yan Zhang1,2, Mian Long1,2
1Center of Biomechanics and Bioengineering and Key Laboratory of Microgravity (National Microgravity Laboratory), Beijing Key Laboratory of Engineered Construction and Mechanobiology, Institute of Mechanics, Chinese Academy of Sciences, Beijing, China. 2School of Engineering Science, University of Chinese Academy of Sciences, Beijing, China.
O0635 Heparan Sulfate Proteoglycans Modulates Shear-induced Angiogenesis Ping Zhao1, Xiao Liu1, Hongyan Kang1, Anqiang Sun1, Yubo Fan1,2,3, Xiaoyan Deng1
1Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, China. 2National Research Center for Rehabilitation Technical Aids, Beijing, China. 3Key Laboratory of Rehabilitation Aids Technology and System of the Minisrty of Civil Affairs, Beijing, China.
O0636 Computational study of the nodal flow with a small number of cilia: comparison of mechanosensing and vesicle transport hypotheses Toshihiro Omori1, Kyosuke Shinohara2, Hiroshi Hamada3, Takuji Ishikawa1
1Tohoku University, Sendai, Japan. 2Tokyo University of Agriculture and Technology, Tokyo, Japan. 3RIKEN, Center for Developmental Biology, Kobe, Japan.
O0637 Role of glycocalyx of endothelial cells in LDL concentration polarization and trans-intimaltransport Xuejiao Ma, Hongyan Kang, Xiaoyan Deng
School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
O0638 In-silico observation of bone metabolism and remodeling based on mechano-biochemical coupling models Taiji Adachi1,2, Yuki Miya2, Yoshitaka Kameo1,2, Tomoki Nakashima3
1Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan. 2Department of Micro Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan. 3Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
O0641 Novel application of three-dimensional tissue engineered constructs fabricated by human endometrial stromal cells to facilitate early embryo growth and implantation Jeonghyun Kim1, Takayuki Harada1, Yasushi Hirota2, Takehiro Hiraoka2, Osamu Yoshino3, Shigeru Saito3, Yutaka Osuga2, Takashi Ushida4,5, Katsuko Furukawa4,5
1Department of Bioengineering, Graduate school of Engineering, The University of Tokyo, Tokyo, Japan. 2Department of Obstetrics and Gynecology, School of Medicine, The University of Tokyo, Tokyo, Japan. 3Department of Obstetrics and Gynecology, School of Medicine, The University of Toyama, Toyama, Japan. 4Department of Mechanical Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan. 5Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
O0645 DNA breaks in chondrocyte progenitor cells under cyclic hydrostatic pressure Koichiro Maki1,2,3, Katsuko Furukawa1, Takashi Ushida1
1The University of Tokyo, Tokyo, Japan. 2The University of Helsinki, Helsinki, Finland. 3Max Planck Institute for Biology of Ageing, Cologne, Germany.
O0648 Optical coherence elastography for characterizing a 3D in vitro tumor model structural and mechanical properties David Kingsley, Denzel Faulkner, Nicholas Hugenberg, Cassie Roberge, Assad Oberai, Xavier Intes, David Corr
Rensselaer Polytechnic Institute, Troy, USA.
O0649 Elastic properties of the zygomatic muscle using ultrasound elastography technique Redouane Ternifi1, Philippe Pouletaut1, Adrien Heintz2, Stéphanie Dakpé3, Sylvie Testelin3, Bernard Devauchelle3, Fabrice Charleux4, Jean-Marc Constans2, Sabine F. Bensamoun1
1Sorbonne University, Université de technologie de Compiègne CNRS UMR 7338 Biomechanics and Bioengineering, Compiègne, France. 2CHU Amiens, Institut Faire Faces, EA Chimère, Imagerie et Radiologie Médicale, Amiens, France. 3CHU Amiens, Institut Faire Faces, EA Chimère, Service de Chirurgie Maxillo-Faciale, Amiens, France. 4ACRIM-Polyclinique Saint Côme, Compiègne, France.
O0650 Mechanical characterization of meningioma with multi-frequency magnetic resonance elastography Efe Ozkaya1, Gloria Fabris1, Priti Balchandani2, Yu Sakai2, Alexander Chartrain2, Raj Shrivastava2, Mehmet Kurt1,2
1STEVENS INSTITUTE OF TECHNOLOGY, HOBOKEN, USA. 2ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, USA.
O0651 Modelling Within-Tissue Wave Propagation Generated by The Pressure Pulse in the Carotid Artery Daniela Tommasin1, Benedict Verhegghe1, Stephen Greenwald2, Patrick Segers1
1IBiTech-bioMMeda, Ghent University, Ghent, Belgium. 2Blizard Institute, Queen Mary University of London, London, United Kingdom.
O0652 Inversion Recovery Magnetic Resonance Poro-Elastography for Encoding Solid and Fluid Motion in Biphasic Media. Ledia Lilaj1, Sebastian Hirsch2, Thomas Fischer1, Jürgen Braun3, Ingolf Sack1
1Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany. 2Berlin Center for Advanced Neuroimaging - BCAN, Charité - Universitätsmedizin Berlin, Berlin, Germany. 3Institute for Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
O0656 Development of a hybrid alginate-ECM hydrogel as a potential bioink for 3D bioprinting Martina M. De Santis1,2, Chiharu Ota2, Rita Costa2, Ali Doryab2, Hani N. Alsafadi1,2, Deniz Bölükbas1, Melanie Königshoff3,2, Darcy E. Wagner1,2
1Department of Experimental Medical Sciences, Lund University, Lund, Sweden. 2Comprehensive Pneumology Center (CPC), Lung Regeneration and Repair (LRR), Helmholtz Zentrum, Munich, Germany. 3Department of Medicine, University of Colorado, Denver, USA.
O0658 The Impact of Aging and Mechanical Stretch on Monocyte Recruitment and Macrophage Polarization in Experimental Ventilator-Induced Lung Injury Michael Valentine, Patrick Link, Joseph Herbert, Franck Kamga-Gninzeko, Manav Parekh, Angela Reynolds, Rebecca Heise
Virginia Commonwealth University, Richmond, USA.
O0659 Dynamic imaging of airways during bronchoconstriction in rats Christopher Waters1, Thien-Khoi Phung2, Scott Sinclair3, Patrudu Makena3, Robert Molthen4
1University of Kentucky, Lexington, Kentucky, USA. 2University of Memphis, Memphis, TN, USA. 3University of Tennessee, Memphis, TN, USA. 4Medical College of Wisconsin, Milwaukee, WI, USA.
O0665 The emergence of contractility in biopolymer networks Pierre Ronceray1, Chase Broedersz2, Martin Lenz3
1Princeton University, Princeton, USA. 2LMU, Munich, Germany. 3Université Paris-Sud & CNRS, Orsay, France.
O0666 Equilibrium physics breakdown reveals the active nature of red blood cell flickering Hervé Turlier1, Dmitry Fedosov2, Basile Audoly3, Thorsten Auth2, Nir Gov4, Cécile Sykes5, Jean-François Joanny6, Gerhard Gompper2, Timo Betz7
1Collège de France, Paris, France. 2Forschungszentrum Jülich, Jülich, Germany. 3Université Pierre et Marie Curie, Paris, France. 4Weizmann Institute, Rehovot, Israel. 5Institut Curie, Paris, France. 6ESPCI, Paris, France. 7University of Münster, Münster, Germany.
O0670 Associations of muscle morphology and selective motor control with muscle strength and gait impairment in children with spastic cerebral palsy Britta Hanssen1, Simon-Henri Schless1, Marije Goudriaan1, Nicky Peeters1, Lynn Bar-On1,2, Kaat Desloovere1
1KU Leuven, Leuven, Belgium. 2VU Medical Center, Amsterdam, Netherlands.
O0671 Quantification of stretch reflexes during gait using treadmill perturbations in children with cerebral palsy Lizeth Sloot1,2, Eline Flux3, Jaap Harlaar3, Annemieke Buizer3, Marjolein van der Krogt3
1Harvard University, John A. Paulson School of Engineering and Applied Sciences, Cambridge, USA. 2Wyss Institute for Biologically Inspired Engineering, Boston, USA. 3Dept. Rehabilitation Medicine, MOVE Research Institute Amsterdam, VU University Medical Center, Amsterdam, Netherlands.
O0672 Impaired Selective Motor Control and Gait Temporal-spatial Parameters in Children with Spastic Cerebral Palsy Joanne Zhou1,2, Evan Lowe2, Katelyn Cahill-Rowley1,2, Gordhan Mahtani1,2, Jeffrey Young1,2, Jessica Rose1,2
1Department of Orthopaedic Surgery, Stanford, CA, USA. 2Motion & Gait Analysis Laboratory, Lucile Packard Children’s Hospital, Palo Alto, CA, USA.
O0674 Active (Not Passive) State Mechanics and Intermuscular Interactions Determine the Pathological Knee Joint Condition in Cerebral Palsy for Gait Relevant Knee Positions Cemre Su Kaya1, Fuat Bilgili2, N. Ekin Akalan2,3, Yener Temelli2, Filiz Ates1,4, Can A. Yucesoy1
1Boğaziçi University, İstanbul, Turkey. 2İstanbul University, İstanbul, Turkey. 3İstanbul Kültür University, İstanbul, Turkey. 4Mayo Clinic, Rochester, MN, USA.
O0676 Effects of functional power training on gait in children with cerebral palsy. Laura Oudenhoven1, Liesbeth van Vulpen1,2, Annemieke Buizer1, Marjolein van der Krogt1
1Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam Movement Sciences, Amsterdam, Netherlands. 2Amsterdam Rehabilitation Research Center, Reade, Amsterdam, Netherlands.
O0678 The trunk as locomotor in cerebral palsy Sebastian Wolf, Mirjam Niklasch, Britta Krautwurst, Thomas Dreher, Firooz Salami
Heidelberg University Clinics, Heidelberg, Germany.
O0681 Interventricular rather than intraventricular dyssynchrony is essential to predict response to cardiac resynchronization therapy: a combined clinical - computational evaluation Peter Huntjens1,2,3, Sylvain Ploux2,3, Marc Strik1,2,3, John Walmsley1, Philippe Ritter2,3, Michel Haissaguerre2,3, Frits Prinzen1, Tammo Delhaas1, Joost Lumens1,2,3, Pierre Bordachar2,3
1Cardiovascular Research Institute Maastricht (CARIM), Maastricht, Netherlands. 2IHU Liryc, Electrophysiology and Heart Modeling Institute, Bordeaux, France. 3Bordeaux University Hospital (CHU), Bordeaux, France.
O0685 Particle-based and haemodynamics modeling for assessing the risk of thrombus formation in left atrial appendages Andy Olivares1, Etelvino Silva2, Marta Nuñez-Garcia1, Constantine Butakoff1, Tom de Potter2, Oscar Camara1
1Department of Information and Communication Technologies,Universitat Pompeu Fabra, Barcelona, Spain. 2Arrhythmia Unit, Department of Cardiology, Cardiovascular Center, Aalst, Belgium.
O0687 Headform Mass, Inertia and Oblique Impact Response Thomas Connor1,2, Matt Stewart2, Roy Burek2, Michael Gilchrist1
1UCD, Dublin, Ireland. 2Charles Owen, Wrexham, United Kingdom.
O0688 Effect of head size over the performance of an Advanced Combat Helmet Marta Palomar Toledano1, Estívaliz Lozano-Mínguez1, Marcos Rodríguez-Millán2, María Henar Miguélez2, Eugenio Giner1
1Department of Mechanical Engineering and Materials-CIIM, Universitat Politècnica de València, Valencia, Spain. 2Department of Mechanical Engineering, Universidad Carlos III de Madrid, Madrid, Spain.
O0689 Video analysis of head impact sensor data from adolescent soccer players Declan Patton1,2, Colin Huber1,3, Kristy Arbogast1,4
1Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, PA, USA. 2Sport Injury Prevention Research Centre, University of Calgary, Calgary, AB, Canada. 3Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. 4Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
O0690 A Comparison Between Two Oblique Impact Test Protocols for Cycling Helmets Kevin Adanty1, James Michio Clark2, Andrew Post1, Thomas Blaine Hoshizaki1, Michael Gilchrist2
1University of Ottawa, Ottawa, Canada. 2University College Dublin, Dublin, Ireland.
O0691 Analysis Of Single Head Impacts Collected In Amateur Athletes Adam Bartsch1, Edward Benzel2, Jay Alberts2, Sergey Samorezov2, Rajiv Dama1, Vincent Miele3, Alok Shah4, MIchael Mccrea4, Brian Stemper4
1PREVENT BIOMETRICS, MINNEAPOLIS, USA. 2CLEVELAND CLINIC, CLEVELAND, USA. 3UNIVERSITY OF PITTSBURGH MEDICAL CENTER, PITTSBURGH, USA. 4MEDICAL COLLEGE OF WISCONSIN, MILWAUKEE, USA.
O0693 Factors Affecting Head Impact Exposure in College Football Practices: A Multi-Institutional Study Eamon Campolettano1, Steven Rowson1, Stefan Duma1, Brian Stemper2, Alok Shah2, Jason Mihalik3, Jaroslaw Harezlak4, Thomas McAllister4, Steven Broglio5, Michael McCrea2
1Virginia Tech, Blacksburg, USA. 2Medical College of Wisconsin, Milwaukee, USA. 3University of North Carolina, Chapel Hill, USA. 4Indiana University, Bloomington, USA. 5University of Michigan, Ann Arbor, USA.
O0696 Effects of Ischemic Regurgitation on Mitral Valve Mechanics and Structure Bruno Rego1, Salma Ayoub1, Amir Khalighi1, Robert Gorman2, Joseph Gorman2, Michael Sacks1
1University of Texas at Austin, Austin, USA. 2University of Pennsylvania, Philadelphia, USA.
O0699 Effect of mechanical tension on 3D co-cultured valvular cells with hydroxyapatite Ablajan Mahmut, Xiaoyin Ma, Andrea Lo, Jennifer Richards, Terence W Gee, Jae Woong Jang, Russell A Gould, Jennie Ann Kunitake, Jooho Kim, Eve Donnelly, Lara A Estroff, Jonathan T Butcher
Cornell University, ithaca, USA.
O0700 Flow- and side-dependent regulation of aortic valve calcification by microRNA-483 in aortic valve endothelial cells Joan Fernandez Esmerats1,2, Robert Nerem2, Ajit Yoganathan2, Hanjoong Jo1,2
1Emory University, Atlanta, USA. 2Georgia Institute of Technology, Atlanta, USA.