A reduced fibril-level stiffness in steroid-induced osteoporosis, arising from a combination of altered mineral nanoparticle shape and lowered matrix mineralization, leads to lower bone quality
Paolino de Falco1,3,
Chris T. Esapa7,
Steve D. M. Brown7,
Roger D. Cox7,
Graham R. Davis9,
Nicola M. Pugno1,10,11,
Rajesh V. Thakker12,
Himadri S. Gupta1
1School of Engineering and Materials Science, Queen Mary University of London, London, United Kingdom.
2Department of Nuclear Engineering, North Carolina State University, Raleigh, USA.
3Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany.
4Department of Mathematical Science and Advanced Technology, Japan Agency for Marine-Earth Science and Technology (JAMSTEC), Yokohama, Japan.
5Department of Mechanical Engineering, University of Moratuwa, Moratuwa, Sri Lanka.
6Department of Bioengineering, Imperial College London, London, United Kingdom.
7MRC Mammalian Genetics Unit and Mary Lyon Centre, MRC Harwell, Harwell, United Kingdom.
8Beamline I22, Diamond Light Source Ltd., Harwell, United Kingdom.
9Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Institute of Dentistry, London, United Kingdom.
10Laboratory of Bio-Inspired & Graphene Nanomechanics, Department of Civil, Environmental and Mechanical Engineering, University of Trento, Trento, Italy.
11Ket Lab, Edoardo Amaldi Foundation, Italian Space Agency, Rome, Italy.
12Academic Endocrine Unit, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom.