Topics Index

Awards - ASME Lissner Award
O0104 H.R. Lissner Medal Louis J. Soslowsky
Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Awards - ASME Mow/Fung/Woo/Nerem Awards
O0103 Robert M. Nerem Medal Roger D. Kamm
Massachusetts Institute of Technology, MA, USA.
O0102 Savio L-Y. Woo Medal Kyriacos A. Athanasiou
University of California, Irvine, California, USA.
Awards - ASME Poster Session BS Level: Cardiovascular Biomechanics, Cellular & Tissue Biomechanics, Biofluid & Biotransport, and Emerging Areas
P2501 A Study on the Spatial Variance in the Mechanics and Microstructure of Heart Valves Samuel Jett, Colton Ross, Jacob Richardson, Cortland Johns, Devin Laurence, Yi Wu, Chung-Hao Lee
University of Oklahoma, Norman, USA.
P2508 Coupled optical-mechanical testing device to study layer dependent mechanical properties of aortic aneurysm tissues Donovan Stagg1, Taisya Sigaeva1, Youssef Beauferris1, Cyrus Fiori1, Maria Pino Alban1, Elena S Di Martino2,3,4
1University of Calgary, Calgary, Canada. 2Department of Civil Engineering, University of Calgary, Calgary, Canada. 3Centre for Bioengineering Research and Education, University of Calgary, Calgary, Canada. 4Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Canada.
P2506 Development of a Micro-Particle Image Velocimetry Platform to Study Thrombosis In Vitro Tice Harkins1, Jeremy Myslowski1, Keefe Manning1,2
1Department of Biomedical Engineering, Pennsylvania State University, University Park, USA. 2Department of Surgery, Penn State Hershey Medical Center, Hershey, USA.
P2500 Feasibility assessment for shape replication of the aortic heart valve using syringe based 3D printing Melissa Hendon1, Mohammad Shaver1, Robin Gomez1, Ahmed Ali1, Jenniffer Bustillos2, Arvind Agarwal2, Sharan Ramaswamy1
1Department of Biomedical Engineering, Florida International University, Miami, USA. 2Department of Mechanical and Materials Engineering, Florida International University, Miami, USA.
P2505 Haemodynamics in the feto-placental vasculature of healthy and intrauterine growth restricted fetuses Nikhilesh Bappoo1, Andrew Evans1, Lachlan Kelsey1, Louis Parker1, Yutthapong Tongpob1, Carmel Moran2, Adrian Thomson2, Megan Holmes2, Caitlin Wyrwoll1, Barry Doyle1
1University of Western Australia, Perth, Australia. 2University of Edinburgh, Edinburgh, United Kingdom.
P2512 Interplay between cerebral hemodynamics and pulsatile brain movement through amplified MRI John Martinez1, Efe Ozkaya1, Samantha Jane Holdsworth2, Kambiz Nael3, Mehmet Kurt1,3
1STEVENS INSTITUTE OF TECHNOLOGY, HOBOKEN, USA. 2University of Auckland, Auckland, New Zealand. 3ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, USA.
P2503 Simulating the mechanical effects of diaphragmatic motion on inferior vena cava collapse Philip Crompton1, Keefe Manning1,2
1Department of Biomedical Engineering, The Pennsylvania State University, University Park, USA. 2Department of Surgery, Penn State Hershey Medical Center, Hershey, USA.
P2504 Ultrasound measurements of regional and temporal variations in the murine reproductive system Hamna Qureshi1, Daniel Capone2, Cassandra Conway2, Kristin Miller2, Craig Goergen1
1Purdue University, West Lafayette, USA. 2Tulane University, New Orleans, USA.
Awards - ASME Poster Session BS Level: Locomotion, Musculoskeletal, Sports Biomechanics, and Central Nervous System
P2521 3D Anatomic Model and Quantitative Assessment of 38 Intracranial Cerebrospinal Fluid Cisterns and Cortical Subarachnoid Space Gabryel Conley Natividad1, Lucas R. Sass1, Olivier Baledent2, Nandan Lad3, Martin Mortazavi4,5, R. Shane Tubbs6, Bryn A. Martin1
1University of Idaho, Department of Biological Engineering, Moscow, USA. 2University Hospital, Amiens, France. 3Duke University, Department of Neurological Surgery, Durham, USA. 4National Skull Base Center, Thousand Oaks, USA. 5California Institute of Neuroscience, Thousand Oaks, USA. 6Seattle Science Foundation, Seattle, USA.
P2524 A Dynamic, Mobile Application Controlled, Brace for Stabilization of the Ankle Joint Greg Frasco1, Rabeeh Majidi2, Chen-Hsiang Yu1, Ali Kiapour3
1Department of Computer Science and Networking, Wentworth Institute of Technology, Boston, USA. 2Department of Electrical Engineering, Wentworth Institute of Technology, Boston, USA. 3Department of Biomedical Engineering, Wentworth Institute of Technology, Boston, USA.
P2527 Active bedsore prevention Andrew Nagal, Jonathan M. Gaines
Worcester Polytechnic Institute, Worcester, Massachusetts, USA.
P2522 Asymmetry in peak ground/pedal reaction forces for transtibial amputees in gait, cycling, and elliptical training Greg Orekhov1, Elizabeth Heyde2, A. Matt Robinson3, Scott Hazelwood1,2, Stephen Klisch1,2
1Mechanical Engineering Department, California Polytechnic State University, San Luis Obispo, USA. 2Biomedical Engineering Department, California Polytechnic State University, San Luis Obispo, USA. 3Hanger Clinic, San Luis Obispo, USA.
P2519 Development of a Multi-joint Linkage Head and Neck Impact Model Rosa Hamalainen, Jodie Sheffels, Calvin Kuo, Michael Fanton, Bianca Yu, David Camarillo
Stanford University, Stanford, USA.
P2515 Effects of Microgravity-induced Compromise of Cell Structure on MSC Mechanoresponse Hallie Touchstone, Conner Patricelli, Matthew Goelzer, Stephanie Tuft, Julia Oxford, Gunes Uzer
Boise State University, Boise, USA.
P2520 Efficacy of booster seat design on the response of the 6-year-old crash test dummy in simulated frontal and oblique sled impacts Nhat Duong1,2, Jalaj Maheshwari1,3, Aditya Belwadi1
1Center for Injury Research and Prevention, The Children’s Hospital of Philadelphia, Philadelphia, USA. 2Drexel University, School of Biomedical Engineering Science and Health Systems, Philadelphia, USA. 3University of Pennsylvania, School of Engineering and Applied Sciences, Philadelphia, USA.
P2514 Gait pattern subgrouping based on lower limb joint angle features in healthy subjects Norifumi Fujii1, Nobuhiro Kito2, Kenta Hirohama1, Syogo Takano1, Takumi Iwano3, Junya ozawa2, Shigehiro Uchida2, Junji Matsuba4
1Hiroshima International University Major in Medical Engineering and Technology Graduate School of Medical Technology and Health Welfare Sciences, Hiroshima, Japan. 2Hiroshima International University Faculty of General Rehabilitation, Hiroshima, Japan. 3Department of Rehabilitation, Tokushima Kensei Hospital, Tokushima Healthy Cooperative Association, Tokushima, Japan. 4Tokyo Teikyo University of Science Faculty of Tokyo Rehabilitaton, Tokyo, Japan.
P2525 Quantification of Intrathecal Cerebrospinal Fluid Dynamics in Patients with Amyotrophic Lateral Sclerosis and Comparison to Controls Tavara S. Freeman1, Lucas R. Sass1, Mohammadreza Khani1, Kyle McCain1, Gregory T. Carter2, Douglas L. Weeks2, Brian Petersen3, Bryn A. Martin1
1University of Idaho, Moscow, USA. 2St. Luke's Rehabilitation Institute, Spokane, USA. 3Inland Imaging, Spokane, USA.
P2517 Relationship between bilateral asymmetry of the trunk muscle volume and club head speed in collegiate golfers Yoka Izumoto1,2, Toshiyuki Kurihara1, Tadashi Suga1, Tadao Isaka1
1Ritsumeikan University, Shiga, Japan. 2Japan Society for the Promotion of Science, Tokyo, Japan.
P2518 Role of Cervical Intervertebral Discs in Head Stabilization Ina Bianca Yu, Rosa Hamalainen, Jodie Sheffels, Calvin Kuo, David Camarillo
Stanford University, Stanford, USA.
P2526 Skis and treads: Products to promote independence for manual wheelchair users in winter conditions Anthony Bertocchi, Brian P. Chrzan, Brianna N. Doerfler, Taylor M. Fenoff, Gavin J. Hambrose, Christopher L. Kudlacik, Katherine Slocum
Clarkson University Potsdam, New York, USA.
Awards - ASME Poster Session MS Level: Cardiovascular Biomechanics, Sport Biomechanics, Devices, and Emerging areas
P2549 A comparison of two dynamic computational models for cardiac mechanics and assessment of intra-myocardial injection as a therapeutic strategy for heart failure Yiling Fan1,2, William Ronan2, Irvin Teh3, Jurgen E. Schneider3, Peter E. McHugh2, Sean B. Leen2, Ellen T. Roche1,2
1Massachusetts Institute of Technology, Cambridge, USA. 2National University of Ireland, Galway, Galway, Ireland. 3University of Leeds, Leeds, United Kingdom.
P2553 A Novel Bioreactor that Applies Dynamic Distortion to 3D Cellular Constructs John Everingham, Abdullah Ahmad, Stephanie Tuft, Conner Patricelli, Trevor Lujan
Boise State University, Boise, USA.
P2546 Computational simulation of vascular remodeling of the pancreaticoduodenal arcades in the presence of celiac artery stenosis Changyoung Yuhn1, Kazuhiro Miyahara2, Katsuyuki Hoshina2, Masaharu Kobayashi3, Marie Oshima3
1Department of Mechanical Engineering, The University of Tokyo, Tokyo, Japan. 2Department of Vascular Surgery, The University of Tokyo Hospital, Tokyo, Japan. 3Interfaculty Initiative in Information Studies, The University of Tokyo, Tokyo, Japan.
P2545 Direct comparison of 4D Flow MRI and Tomographic Particle Image Velocimetry on a patient-specific intracranial aneurysm model Katrina Ruedinger1, Rafael Medero2, Huairen Zhou2, Alejandro Roldan-Alzate2,3
1Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, USA. 2Department of Mechanical Engineering, University of Wisconsin-Madison, Madison, USA. 3Department of Radiology, University of Wisconsin-Madison, Madison, USA.
P2548 Effects of Angiotensin Signaling on Multiscale Aortic Valve Mechanical Properties Jessica Perez, Josh Fahy, Prashanth Ravishankar, Taylor Prince, Kartik Balachandran
University of Arkansas, Fayetteville, USA.
P2541 Finite element analysis of tibiofemoral contact mechanics Erika Fojtik1, Andrew Geeslin2, Peter Gustafson1
1Western Michigan University, Kalamazoo, USA. 2Borgess Orthopedics, Kalamazoo, USA.
P2547 Haemodynamics in the thoracic aorta of patients with aortic valve disease Harrison Caddy1, Lachlan Kelsey1, Louis Parker1, James Mallal1, David Newby2, Marc Dweck2, Barry Doyle1
1University of Western Australia, Perth, Australia. 2University of Edinburgh, Edinburgh, United Kingdom.
P2544 Increased hip adduction and internal rotation correlate with decreased hip frontal dynamic joint stiffness during gait in healthy young women Shogo Takano1, Kenta Hirohama1, Norifumi Fujii1, Shigehiro Uchida2, Junya Ozawa2, Nobuhiro Kito2
1Hiroshima International University Major in Medical Engineering and Technology Graduate School of Medical Technology and Health Welfare Sciences, Hiroshima, Japan. 2Hiroshima International University Faculty of General Rehabilitation, Hiroshima, Japan.
P2550 Tensile Properties of Single Vaginal Smooth Muscle Cells Zachary Miller1, Jeffrey McGuire1, Wally Grant1, Barbara Peruzzi2, Raffaella De Vita3
1Virginia Tech, Blacksburg, USA. 2Children Hospital Bambino Gesù, Rome, Italy. 3Virgina Tech, Blacksburg, USA.
P2543 Towards a better understanding of isolated common iliac artery aneurysms: A computational haemodynamics study Brendon Lim1, Louis Parker1, Lachlan Kelsey1, Janet Powell2, Paul Norman1, Barry Doyle1
1University of Western Australia, Perth, Australia. 2Imperial College London, London, United Kingdom.
Awards - ASME Poster Session MS Level: Biofluid & Biotransport, Cellular & Molecular Biomechanics, and Musculoskeletal Biomechanics
P2539 Assessing attenuation coefficient of Magentic nanoparticle infused Tissue mimicking material during High intenisty focused ultrasound sonication Sai Sameer Paruchuri1, Rupak Banerjee1, Prasanna Hariharan2, Matthew Myers2
1University of Cincinnati, Cincinnati, USA. 2Food and Drug Administration, Silverspring, USA.
P2535 Data acquisition process for musculoskeletal model of human shoulder Pavel Jedlička, Tomáš Ryba, Zdeněk Krňoul, Miloš Železný, Jan Špička
University of West Bohemia, Plzeň, Czech Republic.
P2533 Data-driven sonification of CFD aneurysm models Dan MacDonald1, Richard Windeyer1,2, Thangam Natarajan1, Peter Coppin2,1, David Steinman1
1University of Toronto, Toronto, Canada. 2OCAD University, Toronto, Canada.
P2529 Effect of orientation on osteochondral plugs in a biotribological test system Christoph Bauer1, Eugenia Niculescu-Morzsa1, Vivek Jeyakumar1, Daniela Kern1, Hakan Gocerler2, Ivana Toth2, Stefan Nehrer1
1Danube University Krems, Krems, Austria. 2AC2T research GmbH, Wr. Neustadt, Austria.
P2540 Gene expression and cell morphology of a close-pack MSCs/collagen aggregate Masashi Yamazaki1, Hiromi Miyoshi1, Kei Oya2, Manabu Numao1, Hiromichi Fujie1
1Graduate School of System Design, Tokyo Metropolitan University, Hino, Japan. 2Department of Materials and Life Science, Seikei University, Musashino, Japan.
P2534 Influence of hydration structures on the dynamic viscoelastic property of knee menisci: changes due to maturity Reo Tanabe, Seido Yarimitsu, Hiromichi Fujie
Department of Intelligent Mechanical Systems, Graduate School of System Design, Tokyo Metropolitan University, Tokyo, Japan.
P2537 Multivariate Thoracic Deformity Model for Predicting Pulmonary Function in Early Onset Scoliosis Jennifer Sanville1, Oscar Mayer2, Robert Campbell, Jr.2, Shiker Nair1, Shuait Nair1, Ananya Ganesh1, Sriram Balasubramanian1
1Drexel University, Philadelphia, PA, USA. 2Children's Hospital of Philadelphia, Philadelphia, PA, USA.
P2536 Structural Characterization of Human Lamina Cribrosa and Its Correlation to Pressure-induced Strains Yik Tung Tracy Ling1, Ran Shi1,2, Dan Midgett1, Cathy Nguyen3, Elizabeth Cone-Kimball3, Mary Pease3, Harry Quigley3, Thao Nguyen1
1Department of Mechanical Engineering, Johns Hopkins University, Baltimore, USA. 2School of Material Science, Beijing Institute of Technology, Beijing, China. 3Wilmer Ophthalmological Institute, School of Medicine, Johns Hopkins University, Baltimore, USA.
P2530 The Effect of EMG Biofeedback during Scapular Plane Elevation/Lowering and Functional Task in Patients with Subacromial Impingement Syndrome Lin-Ling Huang1, Wan-Yu Du1, Jiu-Jenq Lin1,2
1School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan. 2Department of Physical Medicine & Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan.
Awards - ASME: Biomechanics at the Cell, Tissue and Multiscale Level
O0759 Characterizing the osteovascular network and blood supply in mouse bones Nicholas Hanne1,2, Andrew Steward1, Elizabeth Easter1, Greet Kerckhofs3, Tatjana Parac-Vogt4, Jacqueline Cole1,2
1North Carolina State University, Raleigh, USA. 2University of North Carolina, Chapel Hill, USA. 3Université catholique de Louvain, Louvain-la-Neuve, Belgium. 4KU Leuven, Leuven, Belgium.
O0757 de novo gene transcription is required for persistent cell motility by controlling cytoskeletal dynamics Devon Mason1,2, James Dawahare2, Dung Trung-Nguyen2, Joseph Collins1, Yang Lin3, Sherry Voytik-Harbin4, Pinar Zorlutuna2, Mervin Yoder3, Joel Boerckel1
1University of Pennsylvania, Philadelphia, USA. 2University of Notre Dame, Notre Dame, USA. 3Indiana University, Indianapolis, USA. 4Purdue University, West Lafayette, USA.
Awards - ASME: Biotransport, Cryopreservation and Cardiovascular Modelling
O0766 FSI models of murine hemodynamics in wild type and Fbln5-/- populations Federica Cuomo1, Jacopo Ferruzzi2, Pradyumn Agarwal1, Chen Li1, Zhenwu Zhuang2, Jay D. Humphrey2, C. Alberto Figueroa1,3
1University of Michigan, Ann Arbor (MI), USA. 2Yale University, New Haven (CT), USA. 3King's College London, London, United Kingdom.
O0765 Inductive rewarming improves recovery of cryopreserved arteries Zonghu Han1, Zhe Gao1, Navid Manuchehrabadi2, Kelvin Brockbank3,4, Christy Haynes5, John Bischof1,6
1Department of Mechanical Engineering, University of Minnesota, Minneapolis, USA. 2AngioDynamics Inc, Latham, USA. 3Department of Bioengineering, Clemson University, Clemson, USA. 4Tissue Testing Technologies LLC, North Charleston, USA. 5Department of Chemistry, University of Minnesota, Minneapolis, USA. 6Department of Biomedical Engineering, University of Minnesota, Minneapolis, USA.
Awards - ASME: Cardiovascular Imaging and Modelling
O0875 On the prediction of plaque growth in atherosclerotic coronary arteries in pigs: which hemodynamic metric is the best? Annette M. Kok1, Ayla Hoogendoorn1, Eline M.J. Hartman1, Diede W. Voorrecht1, Claudio Chiastra2, Kim van der Heiden1, Dirk J. Duncker1, Antonius F.W. van der Steen1, Frank J.H. Gijsen1, Jolanda J. Wentzel1
1Erasmus University Medical Center, Rotterdam, Netherlands. 2Politecnico di Milano, Milan, Italy.
O0878 Propagation-based phase-contrast imaging of aortic dissection in mice: from individual elastic lamella to 3D analysis Gerlinde Logghe1, Bram Trachet1,2, Lydia Aslanidou2, Pablo Villaneuva-Perez3,4, Julie De Backer5, Nikolaos Stergiopulos2, Marco Stampanoni3, Hiroki Aoki6, Patrick Segers1
1IbiTech – bioMMeda, Ghent University, Ghent, Belgium. 2STI IBI-STI LHTC, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland. 3Paul Scherrer Institute, Villigen, Switzerland. 4CFEL (DESY), Hamburg, Germany. 5Department of Cardiology and Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium. 6Cardiovascular Research Institute, Kurume University, Kurume, Japan.
O0874 Verifying Monte Carlo simulations of diffusion tensor cardiovascular magnetic resonance using a finite volume method Jan N Rose1, Sonia Nielles-Vallespin2,3, Pedro F Ferreira3, David N Firmin3, Andrew D Scott3, Denis J Doorly1
1Department of Aeronautics, Imperial College London, London, United Kingdom. 2National Institute of Health, Bethesda, MD, USA. 3CMR Unit, Royal Brompton Hospital, London, United Kingdom.
Awards - ASME: Cardiovascular Mechanics and Cell Biomechanics
O0987 Degradation of arterial collagen with applied strain: critical influence of matrix content and collagen crimp Robert Gaul1,2, David Nolan1,2, Tomasso Ristori3, Sandra Loerakker3, Carlijn Bouten3, Caitríona Lally1,2
1Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland. 2School of Engineering, Trinity College Dublin, Dublin, Ireland. 3Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
O0991 Dual functions of fluid shear stress in developmental EndMT David Bassen1, Gretchen Mahler2, Jeffrey Varner1, Jonathan Butcher1
1Cornell University, Ithaca, USA. 2Binghamton University, Binghamton, USA.
O0989 Thermodynamic framework for cell spreading and dynamic contractility Eoin McEvoy1, Siamak Shishvan2, Vikram Deshpande2, Patrick McGarry1
1National University of Ireland Galway, Galway, Ireland. 2University of Cambridge, Cambridge, United Kingdom.
Awards - ASME: Musculoskeletal Mechanics
O0871 A combined statistical shape modelling and musculoskeletal simulation approach to investigate the effect of patellofemoral geometry on joint mechanics in tibial tubercle osteotomy Allison Clouthier1, Dan Borschneck2, Darryl Thelen3, Kevin Deluzio1, Michael Rainbow1
1Queen's University, Kingston, Canada. 2Kingston General Hospital, Kingston, Canada. 3University of Wisconsin-Madison, Madison, USA.
O0872 Changes in bone tissue strength caused by disruption of the gut microbiome depend on stage of skeletal growth Marysol Luna1, Jason Guss1, Remy Walk1, Marjolein van der Meulen1,2, Christopher Hernandez1,2
1Cornell University, Ithaca, USA. 2Hospital for Special Surgery, New York, USA.
O0870 Comparison of knee joint mechanics in concurrent finite element musculoskeletal model of the healthy and mobile bearing prosthesis knee Liming Shu1, Naohiko Sugita1, Jiang Yao2, Ko Yamamoto1, Mamoru Mitsuishi1
1The University of Tokyo, Tokyo, Japan. 2Dassault Systemes Simulia Corp., Johnston, USA.
O0869 ERα deletion from mature osteoblasts increases severity of load-induced osteoarthritis in female mice Sophia Ziemian1, Olufunmilayo Adebayo1, Amanda Rooney1, Natalie Kelly1, Derek Holyoak1, F. Patrick Ross2, Marjolein van der Meulen1,2
1Cornell University, Ithaca, USA. 2Hospital for Special Surgery, New York City, USA.
O0867 Exploring mechanisms for functional changes in the major bundles of the anterior cruciate ligament of the knee during skeletal growth Stephanie Cone1,2, Lynn Fordham1, Jorge Piedrahita2, Jeffrey Spang1, Matthew Fisher1,2
1University of North Carolina, Chapel Hill, USA. 2North Carolina State University, Raleigh, USA.
Awards - ASME: Sports Biomechanics
O0985 Comparison of reaction force generation between initiating manual wheelchair propulsion at self-selected fast speeds Marisa Papp1, Ian Russell1, Philip Requejo2, Jan Furumasu2, Jill McNitt-Gray1
1University of Southern California, Los Angeles, USA. 2Rancho Los Amigos National Rehabilitation Center, Los Angeles, USA.
O0986 Constant force shock absorbers for preventing traumatic brain injury Michael Fanton1, Elliot Hawkes2, Mehmet Kurt3, Mark Cutkosky1, David Camarillo1
1Stanford University, Stanford, USA. 2UC Santa Barbara, Santa Barbara, USA. 3Stevens Institute of Technology, Hoboken, USA.
O0983 Finite element based pelvic injury metric creation and validation in lateral impact for a human body model Caitlin Weaver1,2,3, Alexander Baker2,3, Matthew Davis2,3, Anna Miller4, Joel Stitzel2,3
1Army Research Laboratory, Aberdeen Proving Ground, USA. 2Wake Forest University School of Medicine, Winston-Salem, USA. 3Virginia Tech-Wake Forest University Center for Injury Biomechanics, Winston-Salem, USA. 4Washington University, Department of Orthopaedic Surgery, St. Louis, USA.
O0984 Injury criterion assessment of high rate lateral loading Donald Sherman1, Cynthia Bir2
1Wayne State University, Detroit, USA. 2University of Southern California, Los Angeles, USA.
O0981 Investigating representative whole spinal alignments in a car occupant posture Fusako Sato1,2, Yusuke Miyazaki3, Atsuhiro Konosu2, Kunio Yamazaki2, Mats Svensson1, Karin Brolin1, Shigehiro Morikawa4, Antonio Ferreiro-Perez5
1Chalmers University of Technology, Gothenburg, Sweden. 2Japan Automobile Research Institute, Tsukuba, Ibaraki, Japan. 3Tokyo Institute of Technology, Tokyo, Japan. 4Shiga University of Medical Science, Shiga, Japan. 5Fundación de Investigación HM Hospitales, Madrid, Spain.
Awards - Asian-Pacific Association for Biomechanics: The Yamaguchi Medal for Young Investigators
O0298 Biomechanical effects of ankle arthrodesis and total ankle arthroplasty surgeries on foot Yan Wang1,2, Qitao Tan1,2, Zengyong Li3, Ming Zhang1,2
1Department of Biomedical Engineering, Hong Kong Polytechnic University, Kowloon, Hong Kong. 2The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China. 3Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability, National Research Center for Rehabilitation Technical Aids, Beijing, China.
O0297 Cell adhesion during bullet and rolling motion in capillaries Naoki Takeishi1, Yohsuke Imai2, Roger Kamm3
1Osaka University, Osaka, Japan. 2Tohoku University, Sendai, Japan. 3Massachusetts Institute of Technology, Cambridge, USA.
O0299 Fascicle behavior of human medical gastrocnemius during isometric contraction after stroke Jongsang Son1,2, Fatemeh Saadat1,2, Sabrina S.M. Lee2, William Zev Rymer1,2
1Shirley Ryan AbilityLab (formerly Rehabilitation Institute of Chicago), Chicago, USA. 2Northwestern University, Chicago, USA.
O0300 Static optimization underestimates co-activation during gait in patients with and without neuromuscular impairment Elyse Passmore1,2,3, Morgan Sangeux1,2,3
1Murdoch Children's Research Institute, Melbourne, Australia. 2The Royal Children's Hospital, Melbourne, Australia. 3University of Melbourne, Melbourne, Australia.
O0301 Topological Defects in epithelia govern cell death and extrusion Thuan Beng Saw1,2, Amin Doostmohammadi3, Vincent Nier4, Philippe Marcq4, Chwee Teck Lim1,2, Julia M. Yeomans3, Benoit Ladoux1
1Mechanobiology Institute, National University of Singapore, NUS, Singapore, Singapore. 2Biomedical EngineeringDepartment, NUS, Singapore, Singapore. 3The Rudolf Peierls Centre for Theoretical Physics, University of Oxford, UK, Oxford, United Kingdom. 4Laboratoire Physico-Chimie Curie, Sorbonne Universités, UPMC Université Paris 6, Institut Curie, Paris, France.
Awards - ESB Clinical Biomechanics award finalists
O0838 Gluteal muscle damage leads to higher in vivo hip joint loads 3 months after total hip arthroplasty Philipp Damm1, Jip Zonneveld1, Sophie Brackertz1, Florian Streitparth2, Florian Winkler1,3,4
1Julius Wolff Institute, Charité, Universitätsmedizin Berlin, Berlin, Germany. 2Klinik für Radiologie, Charité, Universitätsmedizin Berlin, Germany, Berlin, Germany. 3Berlin Brandenburg Center for Regenerative Therapies, Charité, Universitätsmedizin Berlin, Berlin, Germany. 4Center for Musculoskeletal Surgery, Charité, Universitätsmedizin Berlin, Berlin, Germany.
O0840 Laying the foundation for healthy gait asymmetry ranges outside the laboratory in everyday life activities Sónia Alves, Thomas Neitmann, Georg N. Duda, Alison N. Agres, Peter C. Raffalt
Julius Wolff Institut - Charité Universitätsmedizin, Berlin, Germany.
O0841 Selective dorsal rhizotomy normalizes muscle forces during walking in children with spastic cerebral palsy Hans Kainz1, Anja Van Campenhout2, Guy Molenaers2, Friedl De Groote1, Kaat Desloovere1,2, Ilse Jonkers1
1KU Leuven, Leuven, Belgium. 2UZ Leuven, Leuven, Belgium.
O0839 The effects of trabecular cutting on the diastolic and systolic function in ex vivo New Zealand rabbits Hai-Chao Han1, Fatemeh Fatemifar1, Meagan Oglesby2, Danny Escobedo2, Gladys Patricia Escobar2, Ender Finol1, Geoffrey Clarke2, Marc Feldman2
1University of Texas at San Antonio, San Antonio, USA. 2University of Texas Health at San Antonio, San Antonio, USA.
Awards - ESB Student Award finalists
O0731 A three-dimensional multiscale model of fracture healing in mice: Sensitivity of callus microstructure to osteoblast polarization and initial MSC density Duncan C Betts, Matthias Graß, Nicholas Ohs, Angad Malhotra, Patrik Christen, Esther Wehrle, Gisela A Kuhn, Ralph Müller
Institute for Biomechanics, ETH Zurich, Zürich, Switzerland.
O0733 Cartilage on chip: hyper-physiological compression in a microscale platform triggers osteoarthritic traits in a cartilage model Andrea Mainardi1,2, Paola Occhetta2, Emiliano Votta1, Martin Ehrbar3, Ivan Martin2, Andrea Barbero2, Marco Rasponi1
1Departments of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy. 2Departments of Surgery and of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland. 3Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland; Zurich Centre for Integrative Human Physiology, Zurich, Switzerland.
O0732 Modelling bone formation at the cranial sutures in normal and craniosynostotic mice Arsalan Marghoub1, Joseph Libby2, Christian Babbs3, Yiannis Ventikos1, Michael J. Fagan2, Mehran Moazen1
1Department of Mechanical Engineering, University College London, Torrington Place, London, United Kingdom. 2Medical and Biological Engineering, School of Engineering and Computer Science, University of Hull, Hull, United Kingdom. 3Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Awards - German Society of Biomechanics session: Experimental Biomechanics
O1103 Do menisci contribute to the overall friction in the knee joint? Daniela Warnecke, Luisa de Roy, Anita Ignatius, Lutz Dürselen
Institute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, Ulm University Medical Centre, Ulm, Germany.
O1104 Effects of a triceps surae muscle-tendon unit exercise on adaptation and retention of gait stability in older adults: a longitudinal investigation over 1.5 years Gaspar Epro1, Andreas Mierau2, Chris McCrum3, Gert-Peter Brüggemann4, Kiros Karamanidis1
1London South Bank University, London, United Kingdom. 2LUNEX International University of Health, Exercise and Sports, Differdange, Luxembourg. 3Maastricht University Medical Centre+, Maastricht, Netherlands. 4German Sport University Cologne, Cologne, Germany.
O1099 Joint movement paths are affected by running induced fatigue Steffen Willwacher1,2, Maximilian Sanno1, Gert-Peter Brüggemann1,2
1German Sport University Cologne, Cologne, Germany. 2Institute of Functional Diagnostics, Cologne, Germany.
O1102 The effect of long-duration space flight on articular cartilage homeostasis Anja Niehoff1,2, Gert-Peter Brüggemann1,2, Frank Zaucke3, Felix Eckstein4,5, Wilhelm Bloch6, Anne Mündermann7, Seungbum Koo8, Jochen Mester9, Anna-Maria Liphardt1,10
1Institute of Biomechanics and Orthopaedics, German Sport University Cologne, Köln, Germany. 2Cologne Center for Musculoskeletal Biomechanics, Medical Faculty, University of Cologne, Köln, Germany. 3Dr. Rolf M. Schwiete Research Unit for Osteoarthritis, Orthopaedic University Hospital Friedrichsheim gGmbH, Frankfurt a.M., Germany. 4Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria. 5Chondrometrics GmbH, Ainring, Germany. 6Institute of Cardiovascular Research and Sport Medicine, Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Köln, Germany. 7Department of Orthopaedics, University Hospital Basel, Basel, Switzerland. 8School of Mechanical Engineering, Chung-Ang University, Seoul, Korea, Republic of. 9Training Science and Sport Informatics, German Sport University Cologne, Köln, Germany. 10Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Awards - JSME session: Commemorative Lectures on Emerging Technologies for Biomechanics: Beyond the 120th anniversary of the JSME
P1502 Age-related alterations in the coordination patterns between the frontal and transverse plane hip and frontal plane knee kinematic joint movement, during gait Kenta Hirohama1,2, Shogo Takano1, Norifumi Fujii1, Shigehiro utida3, Junya Ozawa3, Nobuhiro Kito3
1Hiroshima International University Major in Medical Engineering and Technology Graduate School of Medical Technology and Health Welfare Sciences, Hiroshima, Japan. 2Sakamidorii Hospital Department of Rehabilitation, Hiroshima, Japan. 3Hiroshima International University Faculty of General Rehabilitation, Hiroshima, Japan.
P1506 Comparative analysis of three-dimensional foot bone kinematics in human and African great apes using a biplanar X-ray fluoroscopy system Kohta Ito1, Takuo Negishi1, Koh Hosoda2, Takeo Nagura3, Tomohiko Ota3, Nobuaki Imanishi3, Masahiro Jinzaki3, Motoharu Oishi4, Naomichi Ogihara1
1Department of Mechanical Engineering, Keio University, Yokohama, Japan. 2Graduate School of Engineering Science, Osaka University, Toyonaka, Japan. 3School of Medicine, Keio University, Tokyo, Japan. 4School of Veterinary Medicine, Azabu University, Yokohama, Japan.
P1507 Design of fabrication machine for 3-dimensional hydrogel blood vessel biomodels Yasutomo Shimizu1, Hiroshi Yoshida2, Tadao Matsunaga3, Yoichi Haga3, Makoto Ohta1
1Institute of Fluid Science, Tohoku University, Sendai, Japan. 2Graduate School of Engineering, Tohoku University, Sendai, Japan. 3Graduate School of Biomedical Engineering, Tohoku University, Sendai, Japan.
O0645 DNA breaks in chondrocyte progenitor cells under cyclic hydrostatic pressure Koichiro Maki1,2,3, Katsuko Furukawa1, Takashi Ushida1
1The University of Tokyo, Tokyo, Japan. 2The University of Helsinki, Helsinki, Finland. 3Max Planck Institute for Biology of Ageing, Cologne, Germany.
P1509 Impact of phenotypes on BAV-based hemodynamics in the left ventricle and aorta: patient-specific modeling Takashi Fujiwara1,2,3, Alex Barker4, Koichi Sughimoto5, Fuyou Liang2,3, Hao Liu1,2,3
1Graduate school of Engineering, Chiba University, Chiba, Japan. 2School of Naval Architecture, Ocean & Civil Engineering, Shanghai Jiao Tong University, Shanghai, China. 3Shanghai Jiao Tong University-Chiba University International Cooperative Research Center (ICRC), Shanghai, China. 4Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. 5Division of Cardiothoracic Surgery, British Columbia Children‘s Hospital, Vancouver, Canada.
P1501 In vivo three-dimensional articular cartilage contact behavior of thumb interphalangeal joint using MRI Yusuke Morise1, Makoto Sakamoto2, Kaito Sugita2, Kiyoko Kazama3, Koichi Kobayashi2, Yuji Tanabe1
1Graduate School of Science and Technology, Niigata University, Niigata, Japan. 2Graduate School of Health Sciences, Niigata University, Niigata, Japan. 3Department of Radiology, Niigata Hand Surgery Foundation, Niigata Hand Care Center, Niigata, Japan.
P1511 Incomplete expansion of flow-diverting stent affects aneurysm haemodynamics: a quantitative comparison between treatments with different severities of incomplete expansion occurring within different segments of the parent artery Mingzi Zhang1,2, Yujie Li1,2, Shin-ichiro Sugiyama3,4, David I. Verrelli2, Yi Qian2, Makoto Ohta1
1Institute of Fluid Science, Tohoku University, Sendai, Japan. 2Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia. 3Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan. 4Department of Neuroanesthesia, Kohnan Hospital, Sendai, Japan.
O0638 In-silico observation of bone metabolism and remodeling based on mechano-biochemical coupling models Taiji Adachi1,2, Yuki Miya2, Yoshitaka Kameo1,2, Tomoki Nakashima3
1Department of Biosystems Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan. 2Department of Micro Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan. 3Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
P1503 Multiscale hemodynamics modeling for infants, children, and adolescents Xiancheng Zhang1, Hideaki Haneishi2, Hao Liu1
1Graduate School of Engineering, Chiba University, Chiba, Japan. 2Center for Frontier Medical Engineering, Chiba University, Chiba, Japan.
O0641 Novel application of three-dimensional tissue engineered constructs fabricated by human endometrial stromal cells to facilitate early embryo growth and implantation Jeonghyun Kim1, Takayuki Harada1, Yasushi Hirota2, Takehiro Hiraoka2, Osamu Yoshino3, Shigeru Saito3, Yutaka Osuga2, Takashi Ushida4,5, Katsuko Furukawa4,5
1Department of Bioengineering, Graduate school of Engineering, The University of Tokyo, Tokyo, Japan. 2Department of Obstetrics and Gynecology, School of Medicine, The University of Tokyo, Tokyo, Japan. 3Department of Obstetrics and Gynecology, School of Medicine, The University of Toyama, Toyama, Japan. 4Department of Mechanical Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan. 5Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
P1500 Precision surface machining by using micro-wet blasting for dental ceramics Takashi Baba1, Yuta Nakashima2, Yoshitaka Nakanishi2
1Graduate School of Science and Technology, Kumamoto University, Kumamoto, Japan. 2Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan.
P1508 Relationship between gastric wall motility and mixing of liquid foods in the stomach Taimei Miyagawa1, Shunichi Ishida2, Gregory O’Grady3, Leo Cheng3, Yohsuke Imai2
1Hirosaki University, Hirosaki, Japan. 2Tohoku University, Sendai, Japan. 3University of Auckland, Auckland, New Zealand.
Awards - National Science Foundation / The Summer Biomechanics, Bioengineering & Biotransport Conference (SB3C) Undergraduate Design Competition
O0887 Development of a partial-hand prosthesis for pediatric amputees Tomas Brindisi, Nicholas Costanzo, Meredith Griffin, Jacob Jacques, Taylor Kwiek, Daniel Macko, Matthew McGuffey, Elizabeth Miele, Nathan Starr, Margret Whelly
Clarkson University Potsdam, New York, USA.
O0889 Mechanical umbrella for power wheelchair users with an interchangeable bracket that increases usability for multiple models Jessica Pieczynski, Tess Vessels, Seth Patterson, Gerardo Hernandez-Moreno, Kasie Wright
Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham AL, 35294, USA.
O0888 Rice University senior capstone: Team hippos don’t lie Sebastian Jia, James Phillips, Matthew O’Gorman, Kelsi Wicker, Wesley Yee, Jijie Zhou
Rice University Houston, Texas, USA.
O0886 The GripAssist: An assistive device designed to increase the autonomy of disabled athletes Ian Babcock1,2, Brenna Barber1,2, Rhys Klauss1,2, Lachlan Murphy1,2, Jacob Schmidt1,2, Cullan Sherlock1,2, Kayla Uplinger1,2, Mary E. West1,2
1College of Engineering, The University of Alabama, Tuscaloosa, Alabama, USA. 2Department of Mechanical Engineering, The University of Alabama, Tuscaloosa, Alabama, USA.
O0890 Wearable tremor dampening device Mikaela Hayward, Hyrum Peterson, Kory Cross, Quincy Stevens, Irsyad Badri
University of Utah, Salt Lake City, UT, USA.
Awards - Société de Biomécanique session: Christian Oddou Award lecture and Young Investigator Awards
O0414 Assessing and improving human movements using sensitivity analysis and digital human simulation Pauline Maurice1, Vincent Padois2, Yvan Measson3, Philippe Bidaud4
1INRIA Nancy Grand Est, Nancy, France. 2Sorbonne Universités, Université Pierre et Marie Curie, Paris, France. 3CEA LIST, Gif sur Yvette, France. 4ONERA, Palaiseau, France.
O0415 Biomechanical study of the action of compression bandages on the lower leg Fanette Chassagne1,2, Pierre Badel1, Reynald Convert2, Pascal Giraux3, Jérôme Molimard1
1Mines Saint-Etienne, CIS-EMSE, SAINBIOSE, Saint-Etienne, France. 2Thuasne, BP243, 92307 Levallois-Perret cedex, France. 3Department of Physical Medicine and Rehabilitation, Faculty of Medicine, University Jean Monnet, Saint-Etienne, France.
O0413 Three-dimensional kinematics of temporo-mandibular joints with moderate dysfunctions compared with the asymptomatic behavior Typhaine Koeppel1,2, Emilie Sapin - de Brosses1,2, Anne-Sophie Bonnet1,2
1Laboratoire d'Etude des Microstructures et de Mécanique des Matériaux, Metz, France. 2Université de Lorraine, Metz, France.
Biofluid and transport - Airway flows and lung transport
O1920 A benchmark case for numerical predictions of airflow and regional deposition in the respiratory system Pantelis Koullapis1, Stavros Kassinos1, Jordi Muela2, Carlos Pérez-Segarra2, Joaquim Rigola2, Oriol Lehmkuhl3, Yan Cui4, Martin Sommerfeld5, Jakub Elcner6, Miroslav Jícha6, Igor Saveljic7, Nenad Filipovic7, František Lízal6, Laura Nicolaou8,9
1University of Cyprus, Nicosia, Cyprus. 2Universitat Politècnica de Catalunya, Terrassa, Spain. 3Barcelona Supercomputing Center, Barcelon, Spain. 4Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany. 5Otto von Guericke-University Magdeburg, Halle, Germany. 6Brno University of Technology, Brno, Czech Republic. 7University of Kragujevac, Kragujevac, Serbia. 8Imperial College London, London, United Kingdom. 9Johns Hopkins University, Baltimore, USA.
O1823 A new index for characterizing the efficiency of ciliary beating Mathieu Bottier1, Sylvain Blanchon1,2, Emilie Bequignon1,3, Gabriel Pelle1, Daniel Isabey1, André Coste1,4, Estelle Escudier5,6, Jean-François Papon1,7,8, James Grotberg9, Marcel Filoche1,10, Bruno Louis1
1INSERM U955 and CNRS ERL 7240, Créteil, France. 2CHU Toulouse, Hôpital des Enfants, Service de pneumologie allergologie pédiatrique, Toulouse, France. 3AP-HP, Hôpital H. Mondor-A. Chenevier, Service d'ORL et de chirurgie cervico-faciale, Créteil, France. 4Hôpital intercommunal, Service d'ORL et de chirurgie cervico-faciale, Créteil, France. 5INSERM U933 and Université Pierre et Marie Curie, Paris, France. 6AP-HP, Hôpital Armand-Trousseau, Service de génétique et d'embryologie médicale, Paris, France. 7-HP, Hôpital Bicêtre, Service d'ORL et de chirurgie cervico-faciale, Le Kremlin-Bicêtre, France. 8Faculté de Médecine, Université Paris-Sud, Le Kremlin-Bicêtre, France. 9Department of Biomedical Engineering, University of Michigan, Ann Arbor, USA. 10Physique de la Matière Condensée, Ecole Polytechnique, CNRS, Université Paris-Saclay, Palaiseau, France.
P4508 A Statistical Shape Model of the Human Nasal Cavity Jan Brünung1, Thomas Hildebrandt1, Matthias Bindernagel2, Natalja Amiridze2, Hans Lamecker2, Stefan Zachow3, Leonid Goubergrits1
1Charité – Universitätsmedizin Berlin; Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Berlin, Germany. 21000shapes GmbH, Berlin, Germany. 3Zuse Institute Berlin, Department for Visual Data Analysis, Berlin, Germany.
O1915 Analysis of the aero-acoustic sound sources of phonation in a synthetic larynx model Stefan Kniesburges1,2, Alexander Lodermeyer3, Matthias Tautz3, Michael Döllinger1,2, Stefan Becker3
1University Hospital Erlangen, Division of Phoniatrics and Pediatric Audiology, Department of Otorhinolaryngology, Erlangen, Germany. 2Friedrich-Alexander University Erlangen-Nürnberg, Faculty of Medicine, Erlangen, Germany. 3Friedrich-Alexander University Erlangen-Nürnberg, Faculty of Engineering, Erlangen, Germany.
O1819 Biomechanics of Cough Clearance Peter Krumpe1,2, Cahit A. Evrensel3,4
1VA Medical Center, Reno, NV, USA. 2Professor emeritus, University of Nevada School of Medicine, Reno, NV, USA. 3Department of Mechanical Engineering, University of Nevada, Reno, Reno, NV, USA. 4Department of Biomedical Engineering, Ankara University, Ankara, Turkey.
O1916 Calculating Breathing Effort in Neonates with Tracheomalacia using Computational Fluid Dynamics and High-Resolution MRI Alister Bates, Nara Higano, Erik Hysinger, Robert Fleck, Paul Kingma, Raouf Amin, Jason Woods
Cincinnati Children's Hospital Medical Center, Cincinnati, USA.
P4504 Chaotic features of oscillatory flow in expanding and contracting pulmonary acinus Takashi Mizutani1, Yuri Inagaki1, Yoshimasa Miyachi1, Toshihiro Sera2, Gaku Tanaka1
1Department of Mechanical Engineering, Chiba University, Chiba, Japan. 2Department of Mechanical Engineering, Kyushu University, Fukuoka, Japan.
P4501 Comparative study of grid generation methods for the simulation of nasal airflow during a sniff Shinya Kimura1, Takashi Sakamoto1, Syuta Miura1, Toshihiro Sera2, Kenji Ono3, Gaku Tanaka1, Denis J. Doorly4, Robert C. Schroter5
1Department of Mechanical Engineering, Chiba University, Chiba, Japan. 2Department of Mechanical Engineering, Kyushu University, Fukuoka, Japan. 3Research Institute for Information Technology, Kyushu University, Fukuoka, Japan. 4Department of Aeronautics, Imperial College London, London, United Kingdom. 5Department of Bioengineering, Imperial College London, London, United Kingdom.
O1917 Coupling Hyperpolarized 3He MRI with In Silico Models to Predict Aerosol Dosimetry in Asthmatic Subjects Kamran Poorbahrami1, David Mummy2, Sean Fain2, Jessica Oakes1
1Northeastern University, Boston, USA. 2University of Wisconsin-Madison, Madison, USA.
P4511 Development of CFD methodology to quantify aerosol leakage percentage of N95 respirators Neha Sharma1, Gavin D'Souza1, Matt Myers2, Suvajyoti Guha2, Rupak Banerjee1, Prasanna Hariharan2
1University of Cincinnati, CINCINNATI, USA. 2Food and Drug Administration, silver spring, USA.
P4510 Effect of Surfactant on Split and Rupture of a Liquid Plug at Lung Airway Bifurcation Hideki Fujioka1, Metin Muradoglu2, Shuichi Takayama3, Jean Nemzek4, James Grotberg4
1Tulane University, New Orleans, USA. 2Koc University, Istanbul, Turkey. 3Georgia Tech, Atlanta, USA. 4University of Michigan, Ann Arbor, USA.
P4507 Effect of virtual surgery of the ventricular folds on the airflow through the human respiratory tract Samuel Voß1, Christoph Arens2, Efstathios Papatsoutsos2, Gábor Janiga1
1Laboratory of Fluid Dynamics and Technical Flows, University of Magdeburg “Otto von Guericke”, Magdeburg, Germany. 2Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Magdeburg, Germany.
O1824 Enhancing mucus clearance by cough through repeated pulses Duygu L. Tuna1,2, Altay Ünal3, Fikret Arı4, Peter Krumpe5,6, Cahit A. Evrensel7,8
1Department of Physics, College of Science, Ankara University, Ankara, Turkey. 2Physics Group, College of Engineering, Atılım University, Ankara, Turkey. 3Department Physics Engineering, College of Engineering, Ankara, Turkey. 4Department of Electrical and Electronics Engineering, College of Engineering, Ankara, Turkey. 5VA Medical Center, Reno, NV, USA. 6University of Nevada School of Medicine, Reno, NV, USA. 7Department of Biomedical Engineering, College of Engineering, Ankara University, Ankara, Turkey. 8Department of Mechanical Engineering, College of Engineering, University of Nevada, Reno, NV, USA.
O1922 Evolution of respiratory flow phenomena with age and implications for inhalation aerosol targeting Prashant Das1, Eliram Nof1, Israel Amirav2, Josue Sznitman1
1Technion - Israel Institute of Technology, Haifa, Israel. 2University of Alberta, Edmonton, Canada.
O1821 Flow Instabilities in the Upper Airways During Phonation Lukas Schickhofer, Mihai Mihaescu
KTH Royal Institute of Technology, Stockholm, Sweden.
P4506 Form, flow and function in the nasal airways. Qiwei Xiao1, Denis Doorly1, Alister Bates2, Lulu Ritchie1,3, Raul Cetto1,3, Robert Schroter4, Neil Tolley3
1Aeronautics Department, Imperial College London, London, United Kingdom. 2Cincinnati Children's Hospital Medical Center, cincinnati, USA. 3Faculty of Medicine, Imperial College London, London, United Kingdom. 4Bioengineering Department, Imperial College London, London, United Kingdom.
O1918 Multi-fidelity modeling of ventilation and aerosol in the healthy and diseased lung Irene Vignon-Clementel1,2, Jessica Oakes3, Nicolas Pozin1,2, Céline Grandmont1,2
1Inria, Paris, France. 2Sorbonne Université, Paris, France. 3Northeastern University, Boston, USA.
O1919 Neonatal CPAP respiratory support: Flow and function of the Infant Flow geometry investigated with computational fluid dynamics. Thomas Drevhammar1, Niclas Berg2,3, Markus Falk1, Stevin van Wyk2, Kjell Nilsson1, Lisa Prahl Wittberg2,3
1Dept. of Women’s and Children’s Health, Karolinska Institute, Solna, Sweden. 2Linné FLOW center, KTH Mechanics, Stockholm, Sweden. 3BioMEx center, KTH, Stockholm, Sweden.
P4502 Numerical study of ventricular folds effects on phonation aerodynamics Hossein Sadeghi, Stefan Kniesburges, Anne Schuetzenberger, Michael Doellinger
Department of Phoniatrics and Pediatric Audiology at the Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Erlangen, Medical School at Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
P4503 Procedure for geometry regularisation to separate the effects of torsion and curvature on flow structure Jan N Rose1, Qiwei Xiao1, Charlotte McIntyre1,2, Neil S Tolley2, Denis J Doorly1
1Department of Aeronautics, Imperial College London, London, United Kingdom. 2Faculty of Medicine, Imperial College London, London, United Kingdom.
O1923 Propagation and rupture of a surfactant-laden liquid plug in distal airways Metin Muradoglu1, Hideki Fujioka2, James B. Grotberg3
1Koc University, Istanbul, Turkey. 2Tulane University, New Orleans, USA. 3The University of Michigan, Ann Arbor (and vicinity), USA.
P4509 Rheological characterization of native human mucus Duygu L. Tuna1,2, Altay Ünal3, Elif Şen4, Koray Ceyhan5, Fatma Çiftci4, H. Barbaros Özer6, Sevgi Saryal4, Sehribani U. Oktay7, Cahit A. Evrensel7,8
1Department of Physics, College of Science, Ankara University, Ankara, Turkey. 2Physics Group, College of Engineering, Atılım University, Ankara, Turkey. 3Department Physics Engineering, College of Engineering, Ankara University, Ankara, Turkey. 4Department of Pulmonary Diseases, School of Medicine, Ankara University, Ankara, Turkey. 5Department of Pathology, School of Medicine, Ankara University, Ankara, Turkey. 6Department of Dairy Technology, College of Agriculture, Ankara University, Ankara, Turkey. 7Department of Mechanical Engineering, College of Engineering, University of Nevada, Reno, NV, USA. 8Department of Biomedical Engineering, College of Engineering, Ankara University, Ankara, Turkey.
O1921 Simulation of fluid-structure interaction using high-order methods with application to sleep disorders Knut Emil Ringstad1, Ehsan Khalili1, Bernhard Müller1, Martin Larsson2
1Norwegian University of Science and Technology, Trondheim, Norway. 2Sportradar AS, Trondheim, Norway.
P4674 Space-time-resolved measurements of aerosol deposition in an idealized model of upper airways Olivier Boiron1,2,3, Eric Bertrand1,3, Ira Katz4,5
1IRPHE CNRS UMR7342, Marseille, France. 2Ecole Centrale Marseille, Marseille, France. 3Aix-Marseille University, Marseille, France. 4Air Liquide Sante International, Paris, France. 5Dpt Mech. eng. Lafayette College, Easton PA, USA.
O1822 Spatiotemporal organization of cilia drives multiscale mucus swirls in model human bronchial epithelium Etienne Loiseau1, Delphine Gras2, Pascal Chanez2, Annie Viallat1
1Aix Marseille Univ, CNRS CINAM, Marseille, France. 2Aix Marseille Univ, CNRS, INSERM, LAI, Marseille, France.
P4500 Upper Airway Flow Characteristics of Obstructive Sleep Apnea Patients who underwent Uvulopalatopharyngoplasty Yan Shang1, Jingying Ye2,1, Song Fu3
1School of Clinical Medicine, Tsinghua University, Beijing, China. 2Beijing Tsinghua Changgung Hospital, Beijing, China. 3School of Aerospace Engineering, Beijing, China.
Biofluid and transport - Biolocomotion and flows
O1814 Biomechanics of flocking flight in swifts and shorebirds Tyson Hedrick, Aaron Corcoran
University of North Carolina at Chapel Hill, Chapel Hill, USA.
P4520 Evolution of directed movements in multicellular animals: Stiffness gradient assisted looping locomotion in hydra Shivprasad Patil, Sanjeev Galande, Shatruhan Rajput, Suyash Naik, Arpita Rouchoudhury, M. K. Unni, Apratim Chatterji, Debanshu Sinha
Indian Institute of Science Education and Research, Pune, India.
P4519 Optimal swimming techniques for the intermediate Reynolds number regime: lessons from larval fish Gen Li1,2, Hao Liu1, Ulrike Müller3, Cees Voesenek4, Johan van Leeuwen4
1Chiba University, Chiba, Japan. 2Japan Agency for Marine-Earth Science and Technology (JAMSTEC), Yokohama, Japan. 3California State University, Fresno, USA. 4Wageningen University, Wageningen, Netherlands.
P4513 The performance of a sea lion's foreflipper as a static wing Megan Leftwich1, Aditya Kulkarni1, Frank Fish2
1George Washington University, Washington, USA. 2West Chester University, West Chester, USA.
Biofluid and transport - Biomechanics of the Central Nervous System
P2565 3D Printed In Vitro Platform for Investigation of Cerebrospinal Fluid Solute Transport Within the Intrathecal Spinal Subarachnoid Space Lucas R. Sass1, Shavaine Byass1, Ayesha Arzumand2, Jon Freund2, Deep Singh2, PJ Anand2, Bryn A. Martin1
1University of Idaho, Department of Biological Engineering, Moscow, USA. 2Alcyone Lifesciences, Lowell, USA.
O0830 A personalised multiporoelastic model for exploring the risk factors associated with the early stages of Alzheimer’s disease John Vardakis1, Liwei Guo1, Dean Chou2, Toni Lassila3, Micaela Mitolo4, Nishant Ravikumar5, Matthias Lange3, Ali Sarrami Foroushani3, Brett Tully6, Zeike Taylor5, Susheel Varma3, Annalena Venneri7, Alejandro Frangi3, Yiannis Ventikos1
1Department of Mechanical Engineering, University College London, London, United Kingdom. 2Department of Mechanical Engineering, National Central University, Taoyuan City, Taiwan. 3Centre for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB), Department of Electronic and Electrical Engineering, University of Sheffield, Sheffield, United Kingdom. 4Functional MR Unit, Policlinico S. Orsola e Malpighi, Department of Biomedical and NeuroMotor Sciences (DiBiNeM), Bologna, Italy. 5Centre for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB), Department of Mechanical Engineering, University of Sheffield, Sheffield, United Kingdom. 6Children’s Medical Research Institute and School of Medical Sciences, Sydney Medical School, The University of Sydney, Sydney, Australia. 7Department of Neuroscience, Medical School, University of Sheffield, Sheffield, United Kingdom.
P2562 Biomechanical modeling and Magnetic Resonance Imaging to investigate CSF flow physiology Patricia Cathalifaud1,2, Mokhtar Zagzoule1,2, Olivier Balédent3,4
1IMFT, Toulouse, France. 2Université toulouse 3, Toulouse, France. 3Laboratoire BioFlowImage, Amiens, France. 4Université de Picardie Jules Verne, Amiens, France.
O0828 Biomechanics of the central nervous system in microgravity Donna Roberts, Davus Asemani, Truman Brown
Medical University of South Carolina, Charleston, S.C., USA.
O0827 Brain injury due to blast overpressure Albert King1, John Cavanaugh1, Liying Zhang1, King Yang1, Xin Jin1, Srinivas Kallakuri1, Ke Feng2, Feng Zhu3, Anil Kalra2, Runzhou Zhou1
1Wayne State Universtiy, Detroit, USA. 2Ford Motor Co., Dearborn, USA. 3Embry-Riddle Aeronautical University, Daytona Beach, USA.
P2560 Cardiac and respiratory effects of intracranial pressure gradient pulsatility on cerebrospinal fluid flow Vegard Vinje1, Geir Ringstad2,3, Per Kristian Eide4,3, Kent-Andre Mardal1,3, Marie E. Rognes1
1Simula Research Laboratory, Oslo, Norway. 2Department of Radiology, Oslo University Hospital - Rikshospitalet, Oslo, Norway. 3University of Oslo, Oslo, Norway. 4Department of Neurosurgery, Oslo University Hospital - Rikshospitalet, Oslo, Norway.
O0825 Contribution of Steady-Streaming to the Bulk Motion of the Cerebrospinal Fluid (CSF) in the Spinal Canal Juan Lasheras1, Jenna Lawrence2, Wilfried Coenen3, Antonio Sánchez3, Victor Haughton4, Carlos Martínez -Bazan5
1University of California San Diego, La Jolla , California, USA. 2University of California San Diego, La Jolla, California, USA. 3University of California, San Diego, La Jolla, California, USA. 4University of Wisconsin, Madison, Wisconsin, USA. 5Universidad de Jaen, Jaen, Spain.
P2564 Investigation of the mechanics underlying brain shift: an image-based approach for the measurement of the in-vivo deformation of the brain tissue. Stefano Zappalà1, Nicholas Bennion1, Rob Harrison2, Jing Wu1, Derek Jones1, Sam Evans1, David Marshall1
1Cardiff University, Cardiff, United Kingdom. 2Renishaw plc., Wotton-under-Edge, Gloucestershire, United Kingdom.
P2561 Micromechanical Modelling of Brain White Matter Andrea Bernardini1, Wenbo Zhan1, Suwen Ge1, Marco Vidotto2, Daniele Dini1
1Imperial College London, London, United Kingdom. 2Politecnico di Milano, Milano, Italy.
P2559 Micromechanics of the Drosophila embryonic central nervous system Ignasi Jorba1,2, Katerina Karkali3, Anand P. Singh4, Timothy E. Saunders4, Daniel Navajas1,2,5, Enrique Martin-Blanco3
1Institute for Bioengineering of Catalonia, Barcelona, Spain. 2Unit of Biophysics and Bioengineering, University of Barcelona, Barcelona, Spain. 3Institute of Molecular Biology of Barcelona (IBMB-CSIC), Barcelona, Spain. 4Mechanobiology Institute, National University of Singapore, Singapore, Singapore. 5CIBER de Enfermedades Respiratorias, Madrid, Spain.
O0824 Non-invasive MRI-guided treatments of the brain using focused ultrasound Kullervo Hynynen
Department of Medical Biophysics, University of Toronto and Sunnybrook Research Institute, Toronto, Ontario, Canada.
P2557 Shear-augmented dispersion in porous media in the periarterial and spinal subarachnoid spaces M. Keith Sharp1, Roxana O. Carare2, Bryn Martin3
1University of Louisville, Louisville, USA. 2University of Southampton, Southampton, United Kingdom. 3University of Idaho, Moscow, USA.
O0829 The effects of coughing and Valsalva on cerebrospinal fluid flow and cranial venous drainage Robert Lloyd1, Iain Ball2, Marcus Stoodley3, David Fletcher4, Lynne Bilston1
1Neuroscience Research Australia & University of New South Wales, Sydney, Australia. 2Philips electronics Australia, Sydney, Australia. 3Department of Clinical Medicine, Macquarie University, Sydney, Australia. 4School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, Australia.
P2558 The roles of vessel pulsation and dilation in clearing extracellular waste from the brain Francesco Costanzo1,2,3, Ravi Kedarasetti1, Christina Echagarruga1, Patrick Drew1,2,4, Bruce Gluckman1,2,4
1Center for Neuroscience, The Pennsylvania State University, State College, USA. 2Department of Engineering Science and Mechanics, The Pennsylvania State University, State College, USA. 3Department of Mathematics, The Pennsylvania State University, State College, USA. 4Department of Biomedical Engineering, The Pennsylvania State University, State College, USA.
O0826 Water transport and homeostasis in the brain Chang Sub Park1, Lea Sanchez2, Grant Hartung1, Andreas Linninger1
1University of Illinois at Chicago, Chicago, USA. 2Ecole Polytechnique Feminie, Sceaux, France.
P2563 What is the actual spatial distribution of craniospinal compliance? Marianne Schmid Daners1, Vartan Kurtcuoglu2,3
1Product Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland. 2The Interface Group, Institute of Physiology, University of Zurich, Zurich, Switzerland. 3Neuroscience Center Zurich, and the Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
Biofluid and transport - Biotransport diagnostics and therapeutics
O0939 Arterial wall oxygen transport and vascular disease revisited Colin G. Caro1, John M. Tarbell2
1Imperial College, London, United Kingdom. 2The City College of New York, New York, USA.
O0941 Assessment of Enhanced Thermal Effect due to Gold Nano-Particles during MR-guided High Intensity Focused Ultrasound (HIFU) Procedures using a Mouse-Tumor Model Surendra Devarakonda1, Maria Lehn2, Edith Janssen2, Keith Stringer2, Matthew Myers3, Rupak Banerjee1
1University of Cincinnati, Cincinnati, USA. 2Cincinnati Children’s Hospital Medical Center, Cincinnati, USA. 3U.S. Food and Drug Administration, Silver Spring, USA.
P2570 Characterization of microvascular malformations based on a computational hemodynamic analysis Sabrina Frey1, Tarcisi Cantieni1, Axel Haine2, Rafael Kammer2, Hendrik von Tengg-Kobligk3, Dominik Obrist1, Iris Baumgartner2
1ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland. 2Swiss Cardiovascular Center, Division of Angiology, University of Bern, Bern University Hospital, Bern, Switzerland. 3Department of Diagnostic, Interventional and Pediatric Radiology, University of Bern, Bern University Hospital, Bern, Switzerland.
P2572 Factors influencing blood electrical conductivity at Couette flow Ivan Ivanov1,2, Nadia Antonova3
1Institute of Experimental Morphology, Pathology and Anthropology with Museum, Sofia, Bulgaria. 2National Sports Academy, Sofia, Bulgaria. 3Institute of Mechanics, Sofia, Bulgaria.
P2567 Intravascular Membrane Catheter for CO2 Reduction: In Vitro Tests and First Results Christoph Janeczek1, Alen Karabegovic1, Florentine Huber-Dangl1, Michael Harasek1, Benjamin Lukitsch1, Claus G. Krenn2, Roman Ullrich2, Reinhard Willinger1, Margit Gföhler1
1Technische Universität Wien, Vienna, Austria. 2CCore Technology, Vienna, Austria.
P2569 White matter hydraulic permeability from electron microscopy images Marco Vidotto1, Michele Gazzara1, Daniela Botnariuc2, Andrea Bernardini3, Daniele Dini3, Elena De Momi1
1Politecnico di Milano, Milan, Italy. 2Faculty of Sciences of the University of Lisbon, Lisbon, Portugal. 3Imperial College London, London, United Kingdom.
Biofluid and transport - Brain biotransport
P2576 Assesment of "glymphatic" system using DTI, CSF tracer and finite element computation. Lars Magnus Valnes1, Geir Ringstad2, Per Kristian Eide2, Kent-Andre Mardal1,3
1University of Oslo, Oslo, Norway. 2Oslo University Hospital, Rikshospitalet, Oslo, Norway. 3Simula Research Laboratory, Oslo, Norway.
O0718 Dynamic blood brain barrier regulation in sub-concussive brain injuries Eoin O'Keeffe1, Eoin Kelly2, Eugene Wallace2, Colin Doherty2, Matthew Campbell1
1Trinity College Dublin, Dublin, Ireland. 2St James's Hospital, Dublin, Ireland.
O0717 In vivo imaging of interstitial flow and histological correlation within the brain tumor microenvironment Jennifer Munson1,2, Kathryn Kingsmore2
1Virginia Tech, Blacksburg, USA. 2University of Virginia, Charlottesville, USA.
O0720 Mapping Perivascular Connectome in Whole Rat Brain in 3D Magdoom Kulam1, Thomas Mareci1, Michael King1, Joshua Yarrow2, Malisa Sarntinoranont1
1University of Florida, Gainesville, USA. 2NF/SG Veterans Health System, Gainesville, USA.
P2577 Modelling the global clearance of soluble Aβ from the human brain Roxana Aldea1, Jamie Foster2, Roxana Carare1, Giles Richardson1
1University of Southampton, Southampton, United Kingdom. 2University of Portsmouth, Portsmouth, United Kingdom.
P2575 Novel brain phantoms for neurological catheter development Owen Lewis1,2,3, Max Woolley3, Dave Johnson3, Julia Fletcher3, Johnathan Fenech3,1, Bethany Keenan1, Matthew Potts1, Peter Hobden1, Sam Evans1
1Cardiff University, Cardiff, United Kingdom. 2Bristol University, Bristol, United Kingdom. 3Renisahw PLC, Gloucestershire, United Kingdom.
P2574 Substrate stiffness modulates the route of transport and not the permeability of the human brain endothelium Manasvini Ammanamanchi1, Xiuying Li1, Xiaoqing Li1, Zhenpeng Qin1,2, Heather Hayenga1
1University of Texas, Dallas, Richardson, USA. 2University of Texas, Southwestern, Dallas, USA.
P2573 The role of brain interstitial transport in Alzheimer’s disease Christina Chan1, Neil Wrigth1, Bingmei Fu2
1Michigan State University, East Lansing, USA. 2CCNY, NY, USA.
O0721 Two-photon uncaging of neuropeptides Xitong Li1, Emre Lacin2, Xiuying Li3, David Kleinfeld4, Paul Slesinger2, Zhenpeng Qin1
1University of Texas at Dallas, Richardson, USA. 2Icahn School of Medicine at Mount Sinai, New York, USA. 3University of Texas at Dallas, Richardosn, USA. 4University of California, San Diego, San Diego, USA.
Biofluid and transport - Cancer microenvironments and tumour transport
O0373 Cell-cell junction dynamics and their role in tumor cell transendothelial migration Michelle Chen1,2, Emad Moeendarbary3,1, Roger D. Kamm1
1Massachusetts Institute of Technology, Cambridge, USA. 2Stanford University, Stanford, USA. 3University College London, London, United Kingdom.
O0379 Cytoskeletal and nuclear dynamics during sustained biaxial confined migration Andrew Holle1,2, Annika Meid1, Ralf Kemkemer3, Joachim Spatz1,2
1Max Planck Institute for Medical Research, Heidelberg, Germany. 2Institute of Physical Chemistry, Heidelberg, Germany. 3Reutlingen University, Reutlingen, Germany.
O0376 Overcoming cancer drug resistance by pyruvate-mediated targeted production of reactive oxygen species in mitochondria Hai Wang1,2, Zan Gao3, Xiaodong "Chris" Li3, Xiaoming "Shawn" He1,2
1University of Maryland, College Park, USA. 2Ohio State University, Columbus, USA. 3University of Virginia, Charlottesville, USA.
O0378 Role of vascular decompression and functional normalization in benefit from metronomic chemotherapy: Insights from a mathematical model Fotios Mpekris1, James W. Baish2, Triantafyllos Stylianopoulos1, Rakesh K. Jain3
1Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus. 2Department of Biomedical Engineering, Bucknell University, Lewisburg, PA, USA. 3Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, USA.
O0377 Tumor Microenvironment of Pontine Glioma Using DCE-MRI and DTI Kulam Magdoom1, Francisco Delgado1, Ana Bohorquez1, Alec Brown1, Paul Carney1, Carlos Rinaldi1, Thomas Mareci1, James Ewing2, Malisa Sarntinoranont1
1University of Florida, Gainesville, USA. 2Henry Ford Hospital, Detroit, USA.
Biofluid and transport - Challenges of thrombosis modelling
O1284 A computational model of the biochemomechanics of evolving occlusive thrombus Manuel Rausch1, Jay Humphrey2
1University of Texas at Austin, Austin, USA. 2Yale University, New Haven, USA.
O1287 A Non-Newtonian Thrombosis Numerical Simulation under Pulsatile Inlet Flow Ling Yang1, Joshua Taylor1, Steven Deutsch1, Keefe Manning1,2
1The Pennsylania State University, University Park, USA. 2Penn State Hershey Medical Center, Hershey, USA.
O1283 A predictive multiscale model for simulating platelet activation and aggregation in shear flow Peng Zhang1, Jawaad Sheriff1, Prachi Gupta2, Marvin J. Slepian3,4, Yuefan Deng2, Danny Bluestein1
1Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA. 2Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA. 3Department of Biomedical Engineering, University of Arizona, Tucson, AZ, USA. 4Sarver Heart Center, University of Arizona, Tucson, AZ, USA.
P3501 Acoustic radiation force induced resonance elastography of coagulating blood: first results from modelling and experiments with six human blood samples Manish Bhatt1, Emmanuel Montagnon1, François Destrempes1, Boris Chayer1, Siavash Kazemirad2, Guy Cloutier1
1University of Montreal Hospital, Montreal, Canada. 2Iran University of Science and Technology, Tehran, Iran, Islamic Republic of.
O1286 Advanced Bioengineering Approaches For The Comprehensive Analysis Of The Thrombogenic Potential Of Frequency Component Elements Of Hemodynamic Shear Stress Profiles Relevant To Cardiovascular Implantable Therapeutic Devices Filippo Consolo1,2, Silvia Bozzi2, Jawaad Sheriff3, Gianfranco Fiore2, Danny Bluestein3, Marvin Slepian4, Alberto Redaelli2
1Università Vita Salute San Raffaele, Milano, Italy. 2Politecnico di Milano, Milano, Italy. 3Stony Brook University, Stony Brook, USA. 4Sarver Heart Center, The University of Arizona, Tucson, USA.
P3502 Cell-free volume and high shear rate as markers for thrombus initiation Britt van Rooij1, Gábor Závodszky1, Victor Azizi1, Alfons Hoekstra1,2
1University of Amsterdam, Amsterdam, Netherlands. 2ITMO University, Saint Petersburg, Russian Federation.
P3500 Continuum Models of Intravascular Blood Clots in Arteries Aaron Fogelson1, Jian Du2, David Ku3
1University of Utah, Salt Lake City, UT, USA. 2Florida Institute of Technology, Melbourne, FL, USA. 3Georgia Institute of Technology, Atlanta, GA, USA.
P3506 Hemodynamics and the Adhesion Kinetics of Platelet Mimetic NanoparticlesHemodynamics and the Adhesion Kinetics of Platelet Mimetic Nanoparticles Yathreb Asaad1, Moran Levi1, Mark Epshtein1, Andrew Yee2,3, David Ginsburg2, Netanel Korin1
1Technion, Haifa, Israel. 2University of Michigan, Ann Arbor, USA. 3Baylor College of Medicine, Houston, USA.
O1282 Hemodynamics controls thrombosis to cause heart attacks and strokes David Ku, Michael Griffin, Yuanzheng Zhu, Cyrus Aidun
Georgia Institute of Technology, Atlanta, USA.
P3507 Influence of intraluminal thrombus on axial features and expansion rate of abdominal aortic aneurysm: computational case study using 3D finite elements Nino Horvat1, Lana Virag1, Jay Humphrey2,3, Igor Karšaj1
1Faculty of Mechanical Engineering and Naval Architecture, University of Zagreb, Zagreb, Croatia. 2Department of Biomedical Engineering, Yale University, New Haven, USA. 3Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, USA.
P3505 Modeling platelet activation in the ECMO circuit Niclas Berg1,2, Gabriel Fuchs3, Mikael Broman4, Lisa Prahl Wittberg1,5
1Linné FLOW center, KTH Mechanics, Stockholm, Sweden. 2BioMEx KTH, Stockholm, Sweden. 3Karolinska Institute, Solna, Sweden. 4ECMO centre Karolinska University Hosptial, Solna, Sweden. 5BioMEx KTH, stockholm, Sweden.
P3503 Numerical simulation of shear-induced platelet activation under high shear flow Denis Pushin1,2, Tatiana Ivanko2, Oleksii Rukhlenko3, Ksenia Zlobina1, Georgy Guria1,2
1National Research Center for Hematology, Moscow, Russian Federation. 2Moscow Insitute of Physics and Technology, Dolgoprudny, Russian Federation. 3University College Dublin, Dublin, Ireland.
P3504 Quantification of Thrombus Formation in Malapposed Coronary Stents Deployed in-vitro Through Imaging Analysis and Computational Fluid Dynamics Simulation Jonathan Brown1, Caroline O'Brien2, Augusto C. Lopes1, Kumaran Kolandaivelu1,3, Elazer Edelman1,3
1Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, USA. 2Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Camrbidge, USA. 3Brigham and Women's Hosptial, Boston, USA.
O1285 Towards Developing Hybrid Particle-continuum Computational Frameworks For Thrombosis And Embolization Biomechanics In Large Arteries Debanjan Mukherjee1, Scott L. Diamond2, Shawn C. Shadden1
1University of California, Berkeley, Berkeley, USA. 2University of Pennsylvania, Philadelphia, USA.
Biofluid and transport - Cryotherapy and cryopreservation (Boris Rubinsky 70th birthday session)
O0147 Cryosurgery and electrolysis - Cryoelectrolysis Franco Lugnani1,2, Boris Rubinsky3
1Hippocrates DOO,, Divaca, Slovenia. 2Clinica Santa Elena, Malaga, Spain. 3University of California Berkeley, Berkeley, USA.
Biofluid and transport - Fluid-structure interactions in cardiovascular mechanics
P4530 3-D mechanical characterization of the bifurcated carotid artery Joerik de Ruijter1, Frans van de Vosse1, Marc van Sambeek2,1, Richard Lopata1
1Eindhoven University of Technology, Eindhoven, Netherlands. 2Catharina Hospital, Eindhoven, Netherlands.
O1716 A comprehensive parametric study of aortic valve function:why is it the way it is? Rana Zakerzadeh1, Ming-Chen Hsu2, Michael Sacks1
1University of Texas at Austin, Austin, USA. 2Iowa State University, Ames, USA.
O1717 A Multi-Patient 3D CT-based Fluid-Structure Interactions Study Comparing Pressure Difference and Shear Stress on Mitral Valve Leaflets in Hypertrophic Obstructive Cardiomyopathy Xueying Huang1,2, Long Deng3, Chun Yang4, Yunhu Song3, Dalin Tang2,5
1Xiamen University, Xiamen, China. 2Worcester Polytechnic Institute, Worcester, China. 3Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. 4China Information Technology Designing & Consulting Institute Co., Ltd., Beijing, China. 5Southeast University, Nanjing, China.
O1605 A new explicit fluid-structure scheme for cardiac valves simulation Ludovic Boilevin-Kayl1,2, Miguel Fernández1,2, Jean-Frédéric Gerbeau1,2
1Inria, Paris, France. 2Sorbonne Université, Paris, France.
P4522 A numerical approach for the analysis of carotid atherosclerosis severity Lina Zouggari1,2, Benyebka Bou-Said2, Antonio Culla1, Francesco Massi1
1DIMA, Sapienza Università di Roma, Roma, Italy. 2LaMCoS, INSA de Lyon, Villeurbanne, France.
O1719 A semi-automated work-flow to perform patient-specific fluid-structure interaction analysis to investigate the mechanics of the mitral valve Benedetta Biffi1,2, Hamad Alkhareef1, Maurizio Gritti3, Marianna Fontana3, Agata Grasso4, Silvia Schievano1, Claudio Capelli1
1Centre for Clinical Cardiovascular Engineering, UCL Institute of Cardiovascular Science & Great Ormond Street Hospital for Children, London, United Kingdom. 2Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom. 3The National Amyloidosis Centre, Division of Medicine, UCL Medical School, Royal Free Hospital, London, United Kingdom. 4Department of Cardiology, Royal Free Hospital, London, United Kingdom.
O1718 Comparing the ‘gold standard’ fluid-structure interaction vs a novel moving-boundary method in blood flow simulations of aortic dissection Mirko Bonfanti1, Stavroula Balabani1, Mona Alimohammadi1, Obiekezie Agu2, Shervanthi Homer-Vanniasinkam1,3,4, Vanessa Díaz-Zuccarini1
1University College London, London, United Kingdom. 2University College London Hospital, London, United Kingdom. 3Leeds Teaching Hospitals, Leeds, United Kingdom. 4University of Warwick Medical School, Warwick, United Kingdom.
O1604 Comparison of Hemodynamic and Structural Indices of Ascending Thoracic Aortic Aneurysm as predicted by 2-way FSI, CFD Rigid Wall Simulation and Displacement-Based FEA Salvatore Pasta1,2, Antonio Condipodero1, Vincent Mendez3, Valentina Agnese2, Diego Bellavia2, Giovanni Gentile2, Giuseppe M Raffa2, Michele Pilato2
1Fondazione RiMED, Palermo, Italy. 2IRCCS Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), Palermo, Italy. 3Ecole Polythechnique Fédérale de Lausanne, Lausanne, Switzerland.
P4527 Computational Fluid Dynamics with Fluid-Structure Interaction in FEBio Jay Shim1, Steve Maas2, Jeffrey Weiss2, Gerard Ateshian1
1Columbia University, New York, USA. 2University of Utah, Salt Lake City, USA.
O1603 Computational fluid-structure interaction methods and their use inthe design of cardiovascular assist devices Yuri Bazilevs1, David Kamensky2, Ming-Chen Hsu3
1School of Engineering, Brown University, Rhode Island, USA. 2Department of Structural Engineering University of California, San Diego, USA. 3Department of Mechanical Engineering Iowa State University, Iowa, USA.
P4526 Computational modeling of repaired coarctation of the aorta: a pilot study to assess the impact of treatment modality José D. Martins1, Diana Oliveira2, Ashwin Prakash3, Justin Zachariah4, Elif Seda Selamet Tierney5, Uyen Truong6, Shaine Morris4, Shelby Kutty7, Sarah D. de Ferranti3, Adélia Sequeira2, Fátima F. Pinto F.1, Tal Geva3, Jorge Tiago2, Miguel M. Carmo8
1Serviço de Cardiologia Pediátrica - Hospital de Santa Marta, Lisboa, Portugal. 2CEMAT - Instituto Superior Técnico, Lisboa, Portugal. 3Department of Cardiology - Boston Children’s Hospital, Harvard Medical School, Boston, USA. 4Division of Pediatric Cardiology - Texas Children's Hospital, Baylor College of Medicine, Houston, USA. 5Division of Pediatric Cardiology, Department of Pediatrics - Lucile Packard Children's Hospital, Stanford University, Palo Alto, USA. 6Division of Pediatric Cardiology - Children's Hospital Colorado, Aurora, USA. 7Joint Division of Pediatric Cardiology Children's Hospital and Medical Center University of Nebraska College of Medicine, Omaha, USA. 8CEDOC Chronic Diseases, Nova Medical School, Lisboa, Portugal.
O1714 Effect of Raphe Extent on the Functionality of Bicuspid Aortic Valves: A Computational Study. Mehdi Ramezanpour1, Farhad Rikhtegar Nezami2, Elazer R. Edelman2,3
1Department of Mechanical Engineering, Tarbiat Modares University, Tehran, Iran, Islamic Republic of. 2Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, USA. 3Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA.
P4534 Effects of Atrial Fibrillation on Haemodynamics in the Left Atrium using 4D PC-MRI Data and Computational Fluid Dynamics Amin Deyranlou1, Alistair Revell1, Josephine Naish1, Christopher Miller2, Amir Keshmiri1
1The University of Manchester, Manchester, United Kingdom. 2Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.
O1606 Fluid-Structure Interaction analysis of a total artificial heart Giulia Luraghi1, Wei Wu1,2, Hector De Castilla3, José Fèlix Rodriguez Matas1, Gabriele Dubini1, Pascal Dubuis3, Marc Grimmé3, Francesco Migliavacca1
1Politecnico di Milano, Milano, Italy. 2University of Texas at San Antonio, San Anonio, USA. 3Carmat, Vélizy-Villacoublay, France.
O1711 Fluid-structure interaction in vascular physiopathology: a multiscale computational approach Daniele Bianchi1, Alessio Gizzi2, Michele Marino3, Giuseppe Vairo1
1University of Rome Tor Vergata, Rome, Italy. 2University Campus Bio-Medico of Rome, Rome, Italy. 3Leibniz Universitat Hannover, Hannover, Germany.
O1712 FSI modelling of a patient-specific AVF. A comparison follow-up study on hemodynamical changes Nicolas Aristokleous, Daniel Moran, Michael T. Walsh
Centre for Applied Biomedical Engineering and Research, School of Engineering, Bernal Institute and the Health Research Institute, University of Limerick, Limerick, Ireland.
P4533 Hemodynamics and Wall Mechanics after Surgical Repair of Aortic Arch: Implication for Better Clinical Decisions Siyeong Ju1, Linxia Gu1, Ibrahim Abdullah2
1University of Nebraska at Lincoln, Lincoln, USA. 2University of Nebraska Medical Center, Omaha, USA.
O1608 Image-Based Mechanical Characterization of Large Blood Vessels for Patient-Specific Simulations Benigno Marco Fanni1, Emanuele Gasparotti1, Francesco Faita2, Nicole Di Lascio2, Silvia Schievano3, Luigi Landini1,4, Simona Celi1, Vincenzo Positano1, Claudio Capelli3
1BioCardioLab, Fondazione CNR-Regione Toscana "G. Monasterio", Massa, Italy. 2CNR Institute of Clinical Physiology, Pisa, Italy. 3Institute of Cardiovascular Science, University College of London, London, United Kingdom. 4Department of Information Engineering, University of Pisa, Pisa, Italy.
O1715 Impact of left ventricular torsion on flow dynamics: a CFD modeling study using the overset mesh method. Federico Canè1, Joris Degroote2, Gianluca De Santis3, Patrick Segers1
1Ghent University, bioMMeda, Ghent, Belgium. 2Ghent University, Ghent, Belgium. 3FEops, Ghent, Belgium.
P4523 Instability of elastic tubes conveying power law fluids Anastasia Poroshina, Vasily Vedeneev
Institute of Mechanics Lomonosov Moscow State University, Moscow, Russian Federation.
P4531 Modelling of a continuous tornado-like blood flow in the channel of left atrium, left ventricle, and aorta Alexander Gorodkov, Eugeny Talygin, Shota Zhorzholiani, Andrey Agafonov, Gennady Kiknadze, Leo Bokeria
Bakulev Research Center for Cardiovascular Surgery, Moscow, Russian Federation.
O1607 Modelling of a human mitral valve within left ventricle with fluid-structure interaction Hao Gao1, Liuyang Feng1, Colin Berry2, B. E. Griffith3, Xiaoyu Luo1
1School of Mathematics and Statistics, University of Glasgow, Glasgow, United Kingdom. 2Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow, United Kingdom. 3University of North Carolina, Chapel Hill, USA.
O1713 Numerical evaluation of the atherosclerosis risk in patient specific aortas: influence of healthy, diseased and prosthetic aortic valve Adrián Herrera-Amaya1, Agustín Vidal-Lesso1, Antonio Aguilera-Cortés1, Miguel Angel Martínez2, Mauro Malvè3
1University of Guanajuato, Guanajuato, Mexico. 2University of Zaragoza, Zaragoza, Spain. 3Public University of Navarra, Pamplona, Spain.
P4521 On the chordae structure and dynamic behaviour of mitral valve Liuyang Feng1, Nan Qi1, Hao Gao1, Wei Sun2, Mariano Vazquez3, Boyce Griffith4, Xiaoyu Luo1
1School of mathematics & statistics, University of Glasgow, Glasgow, United Kingdom. 2Georgia Institute of Technology, Atlanta, USA. 3Barcelona Supercomputing Centre, Barcelona, Spain. 4Departments of Mathematics, Applied Physical Sciences, and Biomedical Engineering and McAllister Heart Institute, University of North Carolina, Chapel Hill, USA.
P4529 The effect of chordae tendineae rupture on left ventricle-valve dynamics: a fluid-structure interaction analysis Andres Caballero1, Wenbin Mao1, Raymond McKay2, Wei Sun1
1Georgia Institute of Technology, Atlanta, USA. 2The Hartford Hospital, Hartford, USA.
P4525 The nonlinear dynamics of Woven Dacron Aortic Prostheses conveying pulsatile blood flow Eleonora Tubaldi, Giovanni Ferrari, Prabakaran Balasubramanian, Michael P. Paidoussis, Marco Amabili
McGill University, Montreal, Canada.
Biofluid and transport - From the microcirculation to large artery flows: Challenges for clinical applications
O1050 Autodigestion: A Missing Link for Biomechanical Analysis of Cardiovascular Dysfunction and Disease Erik B. Kistler1, Geert Schmid-Schönbein2
1Department of Anesthesiology University of California San Diego, La Jolla, California, USA. 2Department of Bioengineering University of California San Diego, La Jolla California, USA.
P2585 Can We Detect Carotid Artery Stenosis From Skin Vibrations: A Computational Investigation of High-Frequent Flow Under Physiological Varying Flow Conditions. Viviana Mancini1, Aslak Bergersen2, Jan Vierendeels3, Patrick Segers1, Kristian Valen-Sendstad2
1Ghent University, bioMMeda, Ghent, Belgium. 2Simula Research Laboratory, Computational Cardiac Modelling, Lysaker, Norway. 3Ghent University, Department of Flow, heat and combustion mechanics, Ghent, Belgium.
P2579 Chordae tendineae rupture alters dynamic deformation of porcine tricuspid valves Keyvan Amini Khoiy1, Samuel Salinas1, Kourosh Asgarian2, Francis Loth1, Rouzbeh Amini1
1The University of Akron, Akron, USA. 2St. Joseph's Regional Medical Ctr., Paterson, USA.
P2590 Clinical applications of flow MRI in head and neck surgery. Jérémie Bettoni1,2, Gwénael Pagé3, Anne-Virginie Salsac4, Agnès Paasche1,2, Sylvie Testelin1,2, Jean-Marc Constans1,5, Bernard Devauchelle1,2, Olivier Balédent3,1, Stéphanie Dakpé1,2
1EA CHIMERE, Amiens, France. 2Maxillo-facial surgery department, University hospital Amiens, France. 3BioFlowImage, Amiens, France. 4UTC, Compiègne, France. 5Clinical Radiology department, University hospital Amiens, France.
P2589 Computational wall shear stress quantification with models derived from X-ray angiogram: exploration for a simpler predictor of coronary atherosclerotic disease progression Ryo Torii1, Anatharaman Ramaswamy2, Alexios Karagiannis3, Antonis Sakellarios4, Thomas Zanchin5, Kyohei Yamaji5, Masanori Taniwaki5, Dik Heg3, Aris Moschovitis5, Maria Radu6, Dimitrios Fotiadis4, Lampros Michalis4, Anthony Mathur2, Patrick Serruys7, Hector Garcia-Garcia8, Christos Bourantas2, Stephan Windecker5, Lorenz Raber5
1University College London, London, United Kingdom. 2Barts Health NHS Trust, London, United Kingdom. 3University of Bern, Bern, Switzerland. 4University of Ioannina, Ioannina, Greece. 5University Hospital of Bern, Bern, Switzerland. 6Copenhagen University Hospital, Copenhagen, Denmark. 7Imperial College London, London, United Kingdom. 8Washington Hospital Center, Washington, USA.
P2584 Effect of a downstream lesion on the apparent fractional flow reserve of a left main coronary artery stenosis: in vitro parametric study Ricardo Coppel1,2, Gérard Finet3,4, François Dérimay3,4, Saami K. Yazdani5, Mauro Malvé6, Jacques Ohayon1,7, Manuel Lagache2,7
1Laboratory TIMC-IMAG/DyCTiM, UGA, CNRS UMR 5525, In3S, Grenoble, France. 2Laboratory SYMME, Annecy-Le-Vieux, France. 3Department of Hemodynamics and Interventional Cardiology, Hospices Civils de Lyon, Lyon, France. 4Claude Bernard University Lyon1; INSERM Unit 886, Lyon, France. 5Department of Mechanical Engineering, University of South Alabama, Mobile, USA. 6Department of Mechanical and Material Engineering, University of Navarra, Pamplona, Spain. 7University Savoie Mont-Blanc, Polytech Annecy-Chambéry, Le Bourget du Lac, France.
P2580 Effects of RBC aggregation and deformability on blood flow in stenosed microvessels Lanlan Xiao1, Jingyu Cui2, Yang Liu2, Shuo Chen3, Bingmei Fu4
1Automotive Engineering College, Shanghai University of Engineering Science, Shanghai, China. 2Department of Mechanical Engineering, The Hong Kong Polytechnic University, Hong Kong, China. 3School of Aerospace Engineering and Applied Mechanics, Tongji University, Shanghai, China. 4Department of Biomedical Engineering, The City College of the City University of New York, New York, USA.
O1052 In vitro biomimetic blood microcirculatory assays for cardiovascular targeted drug carrier design Meirav Belenkovich1, Alison Banka2, Mario Gutierrez2, Netanel Korin1, Lola Eniola-Adefeso2, Josue Sznitman1
1Technion - Israel Institute of Technology, Haifa, Israel. 2University of Michigan, Ann Arbor, USA.
O1048 Model-based personalized Decision Support for heart valve interventions David Rodney Hose1,2,3, Krzysztof Czechowicz1, Gareth Archer4, Patricia V Lawford1,5
1University of Sheffield, Sheffield, United Kingdom. 2Norwegian University of Science and Technology, Trondheim, Norway. 3Insigneo Institute for In Silico Medicine, Sheffield, United Kingdom. 4Sheffield Teaching Hospitals Foundation Trust, Sheffield, United Kingdom. 5Insigneo Institute for in Silico Medicine, Sheffield, United Kingdom.
P2583 Path selection of a spherical capsule in a branched channel: effect of the side branch geometry Z Wang1, Y Sui1, A-V Salsac2, D Barthes-Biesel2, W Wang1
1Queen Mary University of London, London, United Kingdom. 2Universite de Technologie de Compiegne - Sorbonne Universites, Compiegne, France.
P2587 Real-time prediction of capsule deformation using Proper Orthogonal Decomposition Carlos Quesada1, Pierre Villon2, Anne-Virginie Salsac1
1Biomechanics and Bioengineering Laboratory, CNRS - Université de Technologie de Compiègne, Sorbonne Universités, Compiègne, France. 2Roberval Laboratory, CNRS - Université de Technologie de Compiègne, Sorbonne Universités, Compiègne, France.
O1054 Rigidity-induced margination Revaz Chachanidze1,2,3, Othmane Aouane4, Christian Wagner2, Marc Leonetti3
1IRPHE, Marseille, France. 2Universität des Saarlandes, Saarbrücken, Germany. 3LRP, Gières, France. 4Forschungszentrum Jülich, Jülich, Germany.
P2593 Sensitivity of Computationally-Derived Fractional Flow Reserve to GlobalCoronary Flow Reserve Values Jackson Hair1, David Molony2, Habib Samady2, John Oshinski3,1
1Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, USA. 2Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, USA. 3Department of Radiology & Imaging Sciences, Emory University School of Medicine, Atlanta, USA.
P2578 Visualization and quantification of in-vitro bioprosthetic heart valve performance Nina Ebel1, Stefan Kniesburges2, Michael Döllinger2, Michael Weyand1, Markus Kondruweit1
1University Hospital Erlangen, Department of Cardiac Surgery, Erlangen, Germany. 2University Hospital Erlangen, Department of Otorhinolaryngology, Division of Phoniatrics and Pediatric Audiology, Erlangen, Germany.
Biofluid and transport - Hyperthermia and heat-mediated transport
O0038 Molecular Hyperthermia to Manipulate Individual Proteins: Feasibility and Non-Arrhenius Kinetics Daipayan Sarkar1, Peiyuan Kang1, Zhenpeng Qin1,2
1The University of Texas at Dallas, Richardson,TX, USA. 2The University of Texas at Soutwestern Medical Center, Dallas, TX, USA.
Biofluid and transport - Microfluidics
O0490 3D model of Human Blood-Brain Barrier Microvascular Network including iPS-derived Endothelial Cells, brain Pericytes and Astrocytes Marco Campisi1, Yoojin Shin2, Tatsuya Osaki2, Valeria Chiono3, Roger Kamm2,4
1Department of Mechanical and Aerospace Engineering, politecnico di Torino, Turin, Italy. 2Department of Mechanical engineering, Massachusetts Institute of Technology, Cambridge, USA. 3Department of Mechanical and Aerospace Engineering,politecnico di Torino, Turin, Italy. 4Department of Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA.
O0491 A loss of vascular endothelial barrier function by hypoxic exposure Kenichi Funamoto, Yugo Tabata, Rei Koens, Daisuke Yoshino
Tohoku University, Sendai, Japan.
O0488 A microfluidic model of endothelial metabolism in flow Swathi Swaminathan, Sarah Basehore, Alisa Clyne
Drexel University, Philadelphia, USA.
O0494 A microfluidic platform for high-throughput drug screening on 3D functional microtissues Roberta Visone, Giovanni Stefano Ugolini, Alberto Redaelli, Marco Rasponi
Politecnico di Milano, Milan, Italy.
P1522 Cellular and biophysical microenvironmental cues synergistically modulates breast cancer cell migration in a 3D microfluidic culture Karina M. Lugo-Cintron, Maria Virumbrales, Max M. Gong, Lucas Tomko, Patrick N. Ingram, Suzanne M. Ponik, Patricia Keely, David J. Beebe
University of Wisconsin-Madison, Madison, USA.
P1520 Development of a platform for real-time measurement of endothelial hydraulic conductivity under physiological mechanical stimuli Josefin Jansson-Edqvist1,2, Darryl R. Overby2, Anna M. Randi1, Joseph M. Sherwood2
1Vascular Sciences, Imperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom. 2Department of Bioengineering, Faculty of Engineering, Imperial College London, London, United Kingdom.
P1519 Lymphatic microphysiological system recapitulates lymphatic vascular physiology and tumor microenvironmental interactions in vitro Karina M. Lugo-Cintron1, Max M. Gong1, Bridget R. White2, David J. Beebe1
1University of Wisconsin-Madison, Madison, USA. 2University of Wisconsin-Platteville, Platteville, USA.
P1518 Numerical study of a pre-deformed confined spherical capsule relaxing in a fluid at rest Bruno Sarkis1,2, Anne-Virginie Salsac1, Jose-Maria Fullana2
1Laboratoire BioMécanique et BioIngénierie, Université de Technologie de Compiègne, CNRS, Sorbonne Universités, Compiègne, France. 2Institut Jean Le Rond ∂’Alembert, Université Pierre et Marie Curie, CNRS, Sorbonne Universités, Paris, France.
O0492 Quantitative dynamics of red blood cells passing through biomimetic submicron splenic slits Priya Gambhire1, Alexis Moreau1, Scott Atwell1, Cecile Iss1, Huijie Lu2, Catherine Badens3, Zhangli Peng2, Emmanuèle Helfer1, Annie Viallat1, Anne Charrier1
1CINaM, CNRS, Aix Marseille University, Marseille, France. 2Notre Dame University, Southband, USA. 3Aix Marseille Univ, INSERM, GMGF, Marseille, France.
P1521 Unexpected distribution of erythrocytes: when dilute suspensions meet microfluidics Qi Zhou1, Joana Fidalgo2, Lavinia Calvi1, Miguel O. Bernabeu3, Peter R. Hoskins4, Mónica S. N. Oliveira2, Timm Krüger1
1School of Engineering, Institute for Multiscale Thermofluids, The University of Edinburgh, Edinburgh EH9 3FB, United Kingdom. 2James Weir Fluids Laboratory, Department of Mechanical & Aerospace Engineering, University of Strathclyde, Glasgow G1 1XJ, United Kingdom. 3Centre for Medical Informatics, Usher Institute, The University of Edinburgh, Edinburgh EH16 4UX, United Kingdom. 4Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.
Biofluid and transport - Modelling of biofluid transport
O1708 A Canonical Correlation Analysis on the Relationship between Patient-Specific Clinical Attributes and Computational Fluid Dynamics Features in Pulmonary Hypertension Senol Piskin1,2, Sourav Patnaik1, Alifer Bordones1, Srinivas Murali3, Ender Finol1
1University of Texas at San Antonio, San Antonio, USA. 2Koc University Rumelifeneri Kampusu, Istanbul, Turkey. 3Allegheny Health Network, Pittsburgh, USA.
O1601 A poroelastic model of interstitial fluid transport in the limb with gravity effects James Baish1, Timothy Padera2, Lance Munn2
1Bucknell Univesity, Lewisburg PA, USA. 2Massachusetts General Hospital/Harvard Medical School, Boston MA, USA.
O1600 Blood flow and oxygen transfer in feto-placental capillary networksBlood flow and oxygen transfer in feto-placental capillary networks Alexander Erlich1, Philip Pearce2, Romina Plitman Mayo3, Oliver E. Jensen1, Igor L. Chernyavsky1
1University of Manchester, Manchester, United Kingdom. 2Massachusetts Institute of Technology, Cambrdige, MA, USA. 3University of Cambridge, Cambridge, United Kingdom.
O1709 Can morphology or haemodynamic characteristics of vertebrobasilar system be an identifier of hypertension severity? A retrospective study of 43 cases diagnosed with hypertension. Yujie Li1,2, Mingzi Zhang1,2, Ko Kitamura3, Hitomi Anzai4, Shunji Mugikura5, Yi Qian2, Makoto Ohta1
1Institute of Fluid Science, Tohoku University, Sendai, Japan. 2Faculty of Health and Medical Sciences, Macquarie University, Sydney, Australia. 3School of Engineering, Tohoku University, Sendai, Japan. 4Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan. 5Department of Diagnostic Radiology, Tohoku University Hospital, Sendai, Japan.
P4548 CFD Simulation of blood gas transport in a hollowfiber membrane packing for design optimization of intracorporal CO2 removal catheters Benjamin Lukitsch1, Michael Harasek1, Margit Gfoehler1, Christoph Janeczek1, Alen Karabegovic1, Florentine Huber-Dangl1, Claus Krenn2, Roman Ullrich2
1Vienna University of Technology, Vienna, Austria. 2CCORE Technology Gmbh, Vienna, Austria.
P4553 Collateral revascularization: the effect of collateral vasculature presence on hemodynamic metrics in coronary artery bypass grafts Victoria Plyler1, Jacob Key1, Nadia Francis2, Bruce Ferguson1, Stephanie George1
1East Carolina University, Greenville, USA. 2Fisk University, Nashville, USA.
P4561 Craniospinal Model of Blood and Cerebrospinal Fluid: A Biomechanical Approach Karla E. Sanchez-Cazares, Kim H. Parker, Jennifer H. Tweedy
Imperial College London, London, United Kingdom.
P4556 Effects of fixations on haemodynamics of bioprosthetic valves Emilie Sauvage1, Ahmed Khalil1, Stephane Couvreur1, Silvia Schievano1, Gaetano Burriesci2, Martin Andreas3, Claus Rath3, Günther Laufer3, Claudio Capelli1
1Institute of Cardiovascular Science, University College London, London, United Kingdom. 2Department of Mechanical Engineering, University College London, London, United Kingdom. 3Department of Surgery, Division of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
P4544 Experimental flow studies in a model of the left descending coronary artery with Newtonian and non-Newtonian fluids Dieter Liepsch1, Sergey Sindeev2, Sergey Frolov2
1Munich University of Applied Sciences, Munich, Germany. 2Tambov State Technical University, Tambov, Russian Federation.
P4552 Exploring flow disturbances at the carotid bifurcation through an integrated computational hemodynamics & complex networks-based approach Karol Calò1, Muhammad Owais Khan2, Diego Gallo1, Stefania Scarsoglio1, David A. Steinman3, Luca Ridolfi1, Umberto Morbiducci1
1PoliToBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy. 2Cardiovascular Biomechanics Computation Lab, Department of Paediatric Cardiology, Stanford University, Stanford, USA. 3Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada.
P4559 Feasibility of numerical assessment of mitral valve regurgitation using computational fluid dynamics Pavlo Yevtushenko, Katharina Vellguth, Jan Brüning, Leonid Goubergrits, Titus Kühne
Charité - Universitätsmedizin Berlin, Berlin, Germany.
O1594 Fluid mechanics of ureteroscopes Jessica Williams1, Ben Turney2, Derek Moulton1, Sarah Waters1
1Mathematical Institute, University of Oxford, Oxford, United Kingdom. 2Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
O1706 Helical flow assessment in coronary arteries in vivo and its instrumental role in suppressing disturbed shear stress features. An exploratory study. Giuseppe De Nisco1, Annette Kok2, Claudio Chiastra3, Diego Gallo1, Assunta Fabiola Tomeo3, Giuliana Segreto3, Francesco Migliavacca3, Jolanda Wentzel2, Umberto Morbiducci1
1PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy. 2Department of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, Netherlands. 3Laboratory of Biological Structure Mechanics (LaBS), Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Milan, Italy.
O1597 Investigation on the interaction between Nanoparticles and pulmonary membrane Kai Yue, Xiucheng Jin, Jue Tang, Xinxin Zhang
University Of Science and Technology Beijing, Beijing, China.
P4555 Limitations of porous media approach for hollow fiber bundles numerical modelling in blood oxygenators Ricardo Gomez1, Gabriele Dubini1, Beatriz Eguzkitza2, Giancarlo Pennati1
1Politecnico di Milano, Milano, Italy. 2Barcelona Supercomputing Center - Centro Nacional de Supercomputación, Barcelona, Spain.
O1598 Linking flow conditions in membrane oxygenators to arrangements of multimeric von-Willebrand-factor as indication for coagulation Clemens Birkenmaier1,2, Lars Krenkel1,2, Karla Lehle3
1Ostbayerische Technische Hochschule (OTH) Regensburg, Department of Biofluid Mechanics, Regensburg, Germany. 2Regensburg Center of Biomedical Engineering, OTH and University Regensburg, Regensburg, Germany. 3University Medical Center Regensburg, Department of Cardiothoracic Surgery, Regensburg, Germany.
O1704 Mathematical model of fluid status after intravenous fluid infusion Tilaï Rosalina1, Arthur Bouwman2, Wouter Peeters3, Peter Bovendeerd1
1University of Technology Eindhoven, Eindhoven, Netherlands. 2Catharina Hospital Eindhoven, Eindhoven, Netherlands. 3Philips Research, Eindhoven, Netherlands.
P4564 Mathematical modelling of ureteroscope irrigation Jessica Williams, Sarah Waters, Derek Moulton, Ben Turney
University of Oxford, Oxford, United Kingdom.
O1595 Modelisation of blood perfusion into a whole reconstructed adipose tissue vascular network reveals structural and functional heterogeneities Jules Dichamp1, Pol Kennel1, Corinne Barreau2, Christophe Guissard2, Jacques Rouquette3, Anne Lorsignol2, Franck Plouraboué4, Louis Casteilla5
1Institut de mécanique des fluides de Toulouse (IMFT), Université de Toulouse, CNRS, INPT, UPS, Toulouse, France. 2CNRS 5273; UMR STROMALab, BP 84225, F-31 432, Toulouse, France. 3Université de Toulouse ;CNRS; ITAV-USR 3505 ; F31106, Toulouse, France. 4Institut de Mécanique des Fluides de Toulouse (IMFT), Université de Toulouse, CNRS, INPT, UPS, Toulouse, France. 5CNRS 5273; UMR STROMALab, BP 84225, F-31 432 Toulouse Cedex 4, France, Toulouse, France.
P4560 Modelling synovial fluid rheology in elasto-hydrodynamic lubrication Lee Nissim, Hamza Butt, Leiming Gao, Connor Myant, Robert Hewson
Imperial College London, London, United Kingdom.
O1702 Modelling the effect of RBC concentration distributions on microhaemodynamics Joseph Sherwood1, Stavroula Balabani2
1Imperial College London, London, United Kingdom. 2University College London, London, United Kingdom.
P4557 Multiscale modeling of the Glycocalyx Layer: Its impact on hemodynamics Vlasis Mitsoulas, Konstantinos Giannokostas, Yiannis Dimakopoulos, John Tsamopoulos
University of Patras, Patras, Greece.
P4563 Novel and automatic conversion of image-based models into analysis-suitable representations Adam Updegrove1, Nathan Wilson2,3, Jessica Zhang4, Shawn Shadden1
1University of California, Berkeley, Berkeley, USA. 2Open Source Medical Software Corporation, Santa Monica, USA. 3University of California, Los Angeles, Los Angeles, USA. 4Carnegie Mellon University, Pittsburgh, USA.
P4545 Numerical simulation of Blood Flow and LDL Transport in Rabbit Aorta Xiaoyin Li1,2,3, Xiao Liu1,2,3, Anqiang Sun1,2,3, Hongyan Kang1,2,3, Xiaoyan Deng1,2,3, Yubo Fan1,2,3
1Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, China. 2National Research Center for Rehabilitation Technical Aids, Beijing, China. 3Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, China.
P4550 Realistic parametrization for designing hemodynamically optimized arteriovenous grafts Sjeng Quicken1, Barend Mees2, Jan Tordoir2, Tammo Delhaas1, Wouter Huberts1
1CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands. 2Department of Vascular Surgery, Maastricht University Medical Centre, Maastricht, Netherlands.
O1596 The effect of Chiari malformation and syringomyelia on perivascular flow Robert Lloyd1, David Fletcher2, Elizabeth Clarke3, Lynne Bilston1
1Neuroscience Research Australia & University of New South Wales, Sydney, Australia. 2School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, Australia. 3Murray Maxwell Biomechanics Laboratory, Institute for Bone and Joint Research, Kolling Institute of Medical Research, Sydney Medical School, University of Sydney, Sydney, Australia.
P4541 The Influence of Pulsatility on the Flow in a Patient-Specific AV Fistula Neda Alam1, Sita Drost2, David Newport1
1University of Limerick, Limerick, Ireland. 2Delft University of Technology, Delft, Netherlands.
O1599 Transient Effects of NO Production/Diffusion in Microvessels Konstantinos Giannokostas, Yiannis Dimakopoulos, John Tsamopoulos
University of Patras, Patras, Greece.
Biofluid and transport - Nanotherapeutics and nanoparticle transport
O0262 Augmented brain-penetrating nanoparticle dispersion and non-viral transfection via brain tissue pre-treatment with pulsed focused ultrasound Colleen T. Curley1, Brian P. Mead1, Namho Kim2, Karina Negron2, Ji Song1, G. Wilson Miller1, William Garrison1, Alexander Klibanov1, Jung Soo Suk2, Justin Hanes2, Richard J. Price1
1University of Virginia, Charlottesville, USA. 2Johns Hopkins University, Baltimore, USA.
O0266 Development of a Gene-Activated Nerve Guidance Conduit for Peripheral Nerve Repair William Lackington1,2,3, Rosanne Raftery1,2,3, Fergal O'Brien1,2,3
1Tissue Engineering Research Group, Royal College of Surgeons in Ireland, Dublin, Ireland. 2Trinity Center for Bioengineering, Trinity College Dublin, Dublin, Ireland. 3Advanced Materials and Bioengineering Research Center, Dublin, Ireland.
P1525 Metallic-based nanoparticles and blood-brain barrier: present and future perspectives Aisling Ross1,2, David McNulty3, Colm O'Dwyer3,4, Andreas M. Grabrucker1,5, Patrick Cronin1,6, John J. M. Mulvihill1,2
1Bernal Institute, University of Limerick, Limerick, Ireland. 2School of Engineering, University of Limerick, Limerick, Ireland. 3School of Chemistry, University College Cork, Cork, Ireland. 4Micro-Nano Systems Centre, Tyndall National Institute, Cork, Ireland. 5Department of Biological Sciences, University of Limerick, Limerick, Ireland. 6School of Natural Sciences, University of Limerick, Limerick, Ireland.
P1524 Numerical simulations of blood flow-mediated nanoparticles transport into tumour tissue Veronica Carla Gonella1, Diego Gallo2, Michael Handler1, Friedrich Hanser1, Umberto Morbiducci2, Daniel Baumgarten1
1Institute of Electrical and Biomedical Engineering, UMIT - Private University for Health Sciences, Medical Informatics and Technology, Hall in Tirol, Austria. 2PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Torino, Italy.
O0263 Shear-responsive DNA-origami nano-carriers for targeted drug delivery applications Oren M. Rotman1, Matan Yah Ben-Zion2, Shmuel Einav1, Nadrian C. Seeman3, Danny Bluestein1
1Biomedical Engineering Department, Stony Brook University, Stony Brook, NY, USA. 2Department of Physics, New York University, New York, NY, USA. 3Department of Chemistry, New York University, New York, NY, USA.
O0264 Ultrafast pulsed laser induced nanocrystal transformation in colloidal plasmonic vesicles Mohammad Rezaul Karim1, Xiuying Li1, Peiyuan Kang1, Jaona Randrianalisoa2, Zhenpeng Qin1,3, Dong Qian1
1University of Texas at Dallas, Richardson, USA. 2University of Reims Champagne-Ardenne, Reims, France. 3University of Texas Southwestern Medical Center, Dallas, USA.
O0265 Vascularized Liver and Tumor Microenvironments for Determination of Transport and Delivery of Drugs Alican Ozkan1, Neda Ghousifam1, Rhys Michna1, Marissa Nichole Rylander1,2,3
1Department of Mechanical Engineering, The University of Texas at Austin, Austin, TX, USA. 2Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA. 3Institute of Computational Engineering and Sciences, The University of Texas at Austin, Austin,TX, USA.
Biofluid and transport - Vascular, lymphatic, and ocular transport
P1528 A Computational Model Of An Initial Lymphatic Network. Bernard Ikhimwin1, Samira Jamalian2, Charlie Macaskill1, Christopher Bertram1
1University of Sydney, Sydney, Australia. 2Johns Hopkins University, Baltimore, USA.
P1535 A lumped parameter model of mechanically mediated acute and long-term adaptations of contractility and geometry in lymphangions and lymphatic chains. Mohammad Razavi1, Alexander Caulk2, Tyler Nelson1, Zhanna Nepiyushchikh1, J. Brandon Dixon1, Rudolph Gleason1
1Georgia Institute of Technology, Atlanta, GA, USA. 2Yale University, New Haven, CT, USA.
O0604 In vitro and Computational Modelling of the Eye for Evaluating the Delivery of Therapeutics in the Treatment of Retinal Pathologies Alys Davies1, Serban Pop2, Rachel Williams1, Victoria Kearns1
1Eye and Vision Science, University of Liverpool, Liverpool, United Kingdom. 2Computer Science, University of Chester, Chester, United Kingdom.
O0602 Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction Dennis Jones1, Eelco Meiijer1, Cedric Blatter1, Shan Liao2, Ethel Pereira1, Echoe Bouta1, Keehoon Jung1, Lance Munn1, Benjamin Vakoc1, Michael Otto3, Timothy Padera1
1Massachusetts General Hospital, Boston, MA, USA. 2University of Calgary, Calgary, AB, Canada. 3National Institutes of Health, Bethesda, MD, USA.
P1534 Modeling the interaction between the lymphatic capillaries and the interstitium in normal and lymphedema conditions Ghazal Adeli Koudehi1, Carlos Alejandro Silvera Delgado2, Charlotte Debbaut1, Christophe Casteleyn1, Pieter Cornillie1, Patrick Segers1
1Ghent University, Ghent, Belgium. 2Politecnico Di Torino, Torin, Italy.
P1530 Multi-scale modelling of lymphatic muscle Christopher Morris, James Moore Jr
Imperial College London, London, United Kingdom.
P1531 Physical and electrical analogs of multi-lymphangion systems Benjamin Derleth1, Benjamin Twigg1, Luke Riexinger1, Lance Munn2, James Baish1
1Bucknell University, Lewisburg PA, USA. 2Massachusetts General Hospital/Harvard Medical School, Boston MA, USA.
P1537 The Effect of Valve Mechanics on Collecting Lymphatic Transport: a Mathematical Model Huabing Li1,2, Yumeng Mei1, Timothy Padera3, James Baish4, Lance Munn2
1Guilin University of Electronic Technology, Guilin, China. 2Massachusetts General Hospital, Charlestown, USA. 3Massachusetts General Hospital, Boston, USA. 4Bucknell University, Lewisburg, PA, USA.
O0603 The relationship between lymphatic pump function and tissue swelling in lymphedema J. Brandon Dixon1, Tyler Nelson2, Matthew Cribb2, Mohammad Razavi2, Rudolph Gleason2
1Georgia Institute of Technology, Atlanta, Georgia. 2Georgia Institute of Technology, Atlanta, USA.
Biofluid and transport - Verification, validation and uncertainty quantification in cardiovascular CFD
P3512 Analysis of Inlet Velocity Profile Boundary Conditions in Numerical Assessment of Fontan Hemodynamics Connor Huddleston1, Zhenglun (Alan) Wei1,2, Phillip Trusty1, Shelly Singh-Gryzbon1, Mark Fogel3, Alessandro Veneziani4, Ajit Yoganathan1
1Georgia Institute Technology, Atlanta, USA. 2Nanjing Medical University, Nanjing, China. 3Children's Hospital of Philadelphia, Philadelphia, USA. 4Emory University, Atlanta, USA.
O1502 Cerebral aneurysm hemodynamic comparison between computational fluid dynamics and dual-venc 4D Flow MRI Joseph Muskat1, Sean Rothenberger1, Ahmadreza Baghaie1, Susanne Schnell2, Michael Markl2,3, Craig Goergen1, Vitaliy Rayz1
1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA. 2Radiology, Northwestern University, Chicago, Illinois, USA. 3Biomedical Engineering, Northwestern University, Evanston, Illinois, USA.
P3509 Computational and Ultrasound Flow Field Correlation within Embryonic Cord Models Sara Naftali, Amir Twil-Cohen, Anat Ratnovsky
School of Medical Engineering, Afeka, Tel Aviv Academic College of Engineering, Tel Aviv, Israel.
O1505 Impact of uncertainties in inlet conditions on the predictions of hemodynamic simulations in ascending thoracic aortic aneurysms Alessandro Boccadifuoco1, Alessandro Mariotti2, Simona Celi3, Katia Capellini3, Maria Vittoria Salvetti2
1Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy. 2Dipartimento di Ingegneria Civile e Industriale, Università di Pisa, Pisa, Italy. 3BioCardioLab - Bioengineering Unit, Ospedale del Cuore, Fondazione CNR - Regione Toscana G. Monasterio, Massa, Italy.
O1504 Modelling the effect of flow variability on intracranial aneurysms with Gaussian processes and lumped parameter models Ali Sarrami-Foroushani, Toni Lassila, Alejandro F. Frangi
Centre for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB), University of Sheffield, Sheffield, United Kingdom.
P3510 Numerical analysis of transitional and turbulent flow features in a patient-specific aorta with severe aortic stenosis Emily Manchester1, Selene Pirola1, Zhao F. Tian2, Omar A. Jarral3, Thanos Athanasiou3, Xiao Yun Xu1
1Department of Chemical Engineering, South Kensington Campus, Imperial College London, London, United Kingdom. 2School of Mechanical Engineering, The University of Adelaide, Adelaide, Australia. 3Department of Surgery and Cancer, St. Mary's Hospital, Imperial College London, London, United Kingdom.
O1506 Reduced models for uncertainty quantification in the cardiovascular network via domain decomposition Sofia Guzzetti1, Luis A Mansilla Alvarez2, Pablo J Blanco2, Kevin T Carlberg3, Alessandro Veneziani1
1Emory University, Department of Mathematics and Computer Science, Atlanta GA, USA. 2Laboratório Nacional de Computação Científica, Petrópolis, Brazil. 3Sandia National Laboratories, Livermore CA, USA.
P3514 Uncertainty in 1D fluid dynamics networks of pulmonary vasculature Mette Olufsen1, Mitchel Colebank1, M Umar Qureshi1, Dirk Huismeier2, Naomi Chesler3
1NC State University, Raleigh, USA. 2University of Glasgow, Glasgow, United Kingdom. 3University of Wisconsin, Madison, USA.
O1503 Uncertainty Quantification in drug-induced arrhythmias Francisco Sahli Costabal1, Kristen Matsuno1, Jiang Yao2, Paris Perdikaris3, Ellen Kuhl1
1Stanford University, Stanford, USA. 2Dassault Systèmes, Providence, USA. 3University of Pennsylvania, Philadelphia, USA.
Biomedical engineering education - Biomedical engineering education 1
P3515 Addressing biomedical diversity via eLearning - an example from a physiology curriculum David Granjon1, Olivier Bonny2,3, François Verrey1, Vartan Kurtcuoglu1, Diane de Zélicourt1
1Institute of Physiology, University of Zurich, Zurich, Switzerland. 2Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland. 3Service of Nephrology, Lausanne University Hospital, Lausanne, Switzerland.
O1274 Differential effects of public and private funding in the medical device industry David N. Ku1, Hyunsung D. Kang2, Elazer R. Edelman3
1Georgia Institute of Technology, Atlanta, USA. 2Berry College, Mount Berry, USA. 3Massachusetts Institute of Technology, Cambridge, USA.
O1273 Effectiveness of a flipped classroom environment adopted in an undergraduate biomedical engineering module – A case study in a South-East Asian cohort Vivek Vasudevan, Alberto Corrias, Martin Buist, Hwa Liang Leo, Choon Hwai Yap
Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore.
P3517 Towards Development of a Novel Dual Workshop Approach to Promote Active Learning in Upper Level Biomedical Engineering Classes Alexander Kotelsky1, Robin Frye1, Jane Buckley2, Mark Buckley1
1University of Rochester, Rochester, USA. 2JCB Consulting, Rochester, USA.
Biomedical engineering education - Biomedical engineering education 2
O1381 The design of a biomedical engineering programme at Queen Mary, University of London Julia C. Shelton1, Daniel L. Bader2, Martin M Knight1, Hazel C Screen1
1School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, United Kingdom. 2Faculty of Health Sciences University of Southampton, Tremona Road, Southampton, SO16 6YD, United Kingdom.
Biomedical engineering education - Public engagement with biomechanics
O1487 Applying a science capital approach to increase engagement with biomechanics Laura-Anne Furlong,
Loughborough University, Loughborough, United Kingdom. National Centre for Sport and Exercise Medicine, Loughborough, United Kingdom.
O1488 Finding the balance between education outreach and research goals Sarah Shultz1, Kelly Sheerin2, Geoffrey Handsfield3, Denny Wells2, Kim Hebert-Losier4, Philip Fink5, Jenny Clarke6, Melanie Bussey7, Robin Queen8
1Massey University, Wellington, New Zealand. 2Auckland University of Technology, Auckland, New Zealand. 3University of Auckland, Auckland, New Zealand. 4University of Waikato, Tauranga, New Zealand. 5Massey University, Manawatu, New Zealand. 6University of Canterbury, Canterbury, New Zealand. 7University of Otago, Dunedin, New Zealand. 8Virginia Tech, Blacksburg, USA.
O1489 National Biomechanics Day: STEM outeach for high school students through the 21st century's breakthrough science Paul DeVita1, Ashley Moulder1, Olukunle Akindahunsi1, Chris Curran1, Erica Bell1, Katherine Knaus2, Anahid Ebrahimi3, Dan Kuhman4, John Drazan5, Max Paquette6, Jason Franz7,8, Teal Darkenwald1, Scott Breloff9,10, Felipe Carpes11, Jill McNitt-Gray12, Rich Willy13, Janet Dufek14, Ross Miller15
1East Carolina University, Greenville, USA. 2University of Virgina, Charlottesville, USA. 3University of Delaware, Newark, USA. 4University of Alabama, Birmingham, USA. 5Rensselaer Polytechnic Institute, Rochester, USA. 6University of Memphis, Memphis, USA. 7North Carolina State Universiy, Raleigh, USA. 8University of North Carolina at Chapel Hill, Chapel Hill, USA. 9Centers For Disease Control & Prevention, Morgantown, USA. 10National Institute for Occupational safety and Health, Morgantown, USA. 11University of Pampa, Uruguaiana, Brazil. 12USC Los Angeles, Los Angeles, USA. 13University of Montana, Missoula, USA. 14University of Nevada, Las Vegas, Las Vegas, USA. 15University of Maryland, College Park, USA.
O1490 Using Sports to Engage Youth in Science, Technology, Engineering and Mathematics (STEM) Outreach John Drazan1, Amy Loya1, Benjamin Horne1, Joan Bechtold2, Robin Queen3,4
1Rensselaer Polytechnic Institute, Troy, USA. 2University of Minnesota, Minneapolis, USA. 3Virginia Tech, Blacksburg, USA. 4Virginia Tech Carilion School of Medicine, Roanoke, USA.
Cardiovascular - Abdominal aortic aneurysms
P3519 A numerical study assessing the hemodynamic differences between two different configurations of ‘visceral hybrid’ repairs of thoracoabdominal aneurysms ChiWei Ong1, Andris Piebalgs2, Claudia Menichini2, Ian Wee3, XiaoYun Xu4, Richard Gibbs5, Arthur Mark Richards6,7,8, HwaLiang Leo1, Andrew MTL Choong6,9,10
1Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore. 2Department of Chemical Engineering, Imperial College London, London, United Kingdom. 3Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. 4Department of Biomedical Engineering, National University of Singapore, London, United Kingdom. 5Department of Surgery and Cancer, Imperial College London, London, United Kingdom. 6Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore. 7Department of Cardiology, National University Heart Centre, Singapore, Singapore. 8Christchurch Heart Institute, University of Otago, Christchurch, New Zealand. 9Division of Vascular Surgery, National University Heart Centre, Singapore, Singapore. 10Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
P3529 A quantitative and qualitative analysis of calcification in abdominal aortic aneurysm Zinan He1, Rosaire Mongrain1, Simon Lessard2, Gilles Soulez2,3
1McGill University, Montréal, Canada. 2Centre de Recherche du CHUM, Montréal, Canada. 3Université de Montréal, Montréal, Canada.
P3527 Analysis of shape variability of abdominal aortic aneurysms Marina Bassilious, Michael W. Gee
Mechanics and High Performance Computing Group, Technische Universität München, Munich, Germany.
O1482 Biomechanical Approach is superior to maximum diameter criterion in predicting Abdominal Aortic Aneurysm rupture - Blinded Study Stanislav Polzer1, T.Christian Gasser2, Robert Vlachovský3, Luboš Kubíček3, Lukáš Lambert4, Vojtěch Man5, Kamil Novák5, Pavel Skácel5, Martin Slažanský5, Jiří Burša5, Michal Tichý6, Robert Staffa3
1Department of Applied Mechanics, VSB-Technical University of Ostrava, Ostrava, Czech Republic. 22 KTH Solid Mechanics, School of Engineering Sciences, KTH Royal Institute of Technology, Stockholm, Sweden. 32nd Department of Surgery, St. Anne's University Hospital, and Faculty of Medicine, Masaryk University, Brno, Czech Republic. 4Department of Radiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic. 5Institute of Solid Mechanics, Mechatronics and Biomechanics, Brno University of Technology, Brno, Czech Republic. 61st Department of Pathology and Anatomy, St. Anne's University Hospital, Brno, Czech Republic.
O1483 Changes in the biomechanical properties of abdominal aortic aneurysm over the time course of expansion Christopher Miller1, Raoul R.F Stevens2,3,1, Andrii Grytsan1, Jacopo Biasetti4, Joy Roy5, Moritz Lindquist5, T. Christian Gasser1
1KTH, Stockholm, Sweden. 2University of Technology, Eindhoven, Netherlands. 3Maastricht University, Maastricht, Netherlands. 4Johns Hopkins University, Baltimore, USA. 5Karolinska Institute, Stockholm, Sweden.
P3521 Comparing hemodynamic and geometric profiles of commercial devices for endovascular AAA repair Paola Tasso1, Anastasios Raptis2, Michalis Xenos3, Maurizio Lodi Rizzini1, Francesca Garelli1, Diego Gallo1, Miltiadis Matsagkas4, Umberto Morbiducci1
1PoliToBIOMed Lab, Departement of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy. 2Institute of Vascular Diseases Laboratory for Vascular Simulations Ioannina, Greece, Ioannina, Greece. 3Department of Mathematics University of Ioannina, Greece, Ioannina, Greece. 4Department of Vascular Surgery, Faculty of Medicine, University of Thessaly, Greece, Thessaly, Greece.
O1376 Development of abdominal aortic aneurysm modeling and elucidating the role of hemodynamic variables in thrombus formation Huan Do1, Byron Zambrano2, Jongeun Choi3, Whal Lee4, Seungik Baek2
1University of Adelaide, Adelaide, Australia. 2Michigan State University, East Lansing, USA. 3Yonsei University, Seoul, Korea, Republic of. 4Seoul National University, Seoul, Korea, Republic of.
O1479 Does aneurysm development weaken the abdominal aortic wall? Results of a 10-year investigation with age-matched controls Suresh M.L. Raghavan1, Alexandre Queiróz Silva2, Gina Camillo Rocha Silvestre2, Erasmo Simão da Silva2
1University of Iowa, Iowa City, USA. 2University of São Paulo Medical School, São Paulo, Brazil.
O1484 Effects of Arterial Morphology on Outcomes for Isolated Common Iliac Artery Aneurysms: A Computational Fluid Dynamics Study of Ruptured and Intact Cases Louis Parker1,2, Lachlan Kelsey1,2, Brendon Lim1,2, Janet Powell3, Ray Ashleigh4, Maarit Venermo5, Igor Koncar6, Paul Norman1,7, Barry Doyle1,2,8
1Vascular Engineering Laboratory, Harry Perkins Institute of Medical Research, Perth, Australia. 2School of Mechanical and Chemical Engineering, The University of Western Australia, Perth, Australia. 3Vascular Surgery Research Group, London, United Kingdom. 4University Hospital of South Manchester, Manchester, United Kingdom. 5Division of Vascular Surgery, Helsinki University Central Hospital, Helsinki, Finland. 6Clinic for Vascular and Endovascular Surgery, Belgrade, Serbia. 7Medical School, The University of Western Australia, Perth, Australia. 8BHF Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, United Kingdom.
P3528 Experimentally validated fluid-structure interaction computational models of abdominal aortic aneurysms Hannah Safi1,2, Nathan Phillips1, Yiannis Ventikos2, Richard Bomphrey1
1Royal Veterinary College, London, United Kingdom. 2University College London, London, United Kingdom.
O1486 Finite element analysis-derived peak wall rupture index is increased in AAA patients prior to rupture and correlates to time to rupture Antti Siika1, Moritz Lindquist Liljeqvist1, Christian Gasser2, Rebecka Hultgren1, Joy Roy1
1Karolinska Institutet, Stockholm, Sweden. 2KTH Royal Institute of Technology, Stockholm, Sweden.
O1481 How Calcifications Can Be Used to Predict Abdominal Aortic Aneurysm Rupture Hilary Barrett1, Eoghan Cunnane1, Julie O'Brien2, Michael Moloney3, Eamon Kavanagh3, Michael Walsh1
1Health Research Institute, School of Engineering, Bernal Institute, University of Limerick, Limerick, Ireland. 2Departments of Radiology,University Hospital Limerick, Limerick, Ireland. 3Department Vascular Surgery, University Hospital Limerick, Limerick, Ireland.
P3525 Impact of backbone on stresses in abdominal aortic aneurysms Ondrej Lisicky1, Stanislav Polzer2, Jiri Bursa1
1Institute of Solid Mechanics, Mechatronics and Biomechanics, Faculty of Mechanical Engineering, Brno University of Technology, Brno, Czech Republic. 2Department of Applied Mechanics, Faculty of Mechanical Engineering, VSB – Technical University of Ostrava, Ostrava, Czech Republic.
O1480 Impact of constitutive descriptions on calculated peak wall stress in abdominal aortic aneurysms Vojtech Man1, Stanislav Polzer2, Thomas Christian Gasser3, Tomas Novotny4, Ondrej Lisicky1, Jiri Bursa1
1Institute of Solid Mechanics, Mechatronics and Biomechanics, Brno University of Technology, Brno, Czech Republic. 2Department of Applied Mechanics, VSB Technical University of Ostrava, Ostrava, Czech Republic. 3KTH Solid Mechanics, School of Engineering Sciences, KTH Royal Institute of Technology, Stockholm, Sweden. 42nd Department of Surgery, St. Anne’s University Hospital and Faculty of Medicine, Masaryk Universityity, Brno, Czech Republic.
P3520 Impact of mechanical properties of intraluminal thrombus on stress prediction in the wall of abdominal aortic aneurysm Michal Hriciste1, Stanislav Polzer2, Vojtech Man1, Jiri Bursa1
1Institute of Solid Mechanics, Mechatronics and Biomechanics, Faculty of Mechanical Engineering, Brno University of Technology, Brno, Czech Republic. 2Department of Applied Mechanics, Faculty of Mechanical Engineering, VSB – Technical University of Ostrava, Ostrava, Czech Republic.
P3523 Inclusion of surrounding tissue in the patient-specific, ultrasound-based modelling of abdominal aortic aneurysms Niels Petterson1, Emiel van Disseldorp1,2, Frans van de Vosse1, Marc van Sambeek1,2, Richard Lopata1
1Eindhoven University of Technology, Eindhoven, Netherlands. 2Catharina Hospital Eindhoven, Eindhoven, Netherlands.
O1478 Influence of multiple overlapping uncovered stents on the local mechanical environment: porosity and cross-stent structure Shuo Wang1, Yongxue Zhang2, Jiaxuan Feng2, Yuan Huang1, Aziz Tokgoz3, Umar Sadat4, Jonathan Gillard1, Qingsheng Lu2, Zhongzhao Teng1
1Department of Radiology, University of Cambridge, Cambridge, United Kingdom. 2Division of Vascular Surgery, Changhai Hospital, Shanghai, China. 3Department of Engineering, University of Cambridge, Cambridge, United Kingdom. 4Cambridge Vascular Unit, Addenbrooke’s Hospital, Cambridge, China.
O1373 Micro-structural damage during the early phase of Angiotensin II-induced dissecting aortic aneurysm: the role of aortic biomechanics Lydia Aslanidou1, Mauro Ferraro1, Bram Trachet1,2, Patrick Segers2, Nikolaos Stergiopulos1
1EPFL, Lausanne, Switzerland. 2Ghent University, Ghent, Belgium.
P3526 Modelling of large abdominal aortic aneurysms using multi-perspective 3D ultrasound Emiel van Disseldorp1,2, Niels Petterson1, Frans van de Vosse1, Marc van Sambeek1,2, Richard Lopata1
1Eindhoven University of Technology, Eindhoven, Netherlands. 2Catharina Hospital, Eindhoven, Netherlands.
P3524 On the Role of Morphological Measures in Abdominal Aortic Aneurysm Rupture Risk Assessment for the Asian and Caucasian Patient Populations Tejas Canchi1,2, Hong Nguyen1, Wei Wu1, Sourav Patnaik1, Eddie Y.K. Ng2, Sriram Narayanan3, Ender Finol1
1University of Texas at San Antonio, San Antonio, USA. 2Nanyang Technological University, Singapore, USA. 3Tan Tock Seng Hospital, Singapore, Singapore.
O1485 Patient-Specific Computational Analysis of the Impact of Fenestrated and Chimney Endovascular Aortic Repair on Haemodynamics in Renal Arteries Sabrina Ben Ahmed1,2,3, Francesca Condemi3,2, Jean-Pierre Favre4,2, C. Alberto Figueroa5,6, Jean-Noel Albertini4,2, Eugenio Rosset1,2, Stephane Avril3,2
1Service de Chirurgie Vasculaire, CHU Clermont-Ferrand, Clermont-Ferrand, France. 2INSERM U1059 SAINBIOSE, Saint-Etienne, France. 3Mines Saint-Étienne CIS-EMSE, Saint-Etienne, France. 4Service de Chirurgie Cardiovasculaire, CHU Saint-Etienne, Saint-Etienne, France. 5Department of Biomedical Engineering, University of Michigan, Ann Arbor, USA. 6Department of Surgery, University of Michigan, Ann Arbor, USA.
O1374 The role of tissue re-modelling in mechanics and pathogenesis of abdominal aortic aneurysms J.A. Niestrawska1, P. Regitnig2, C. Viertler2, T.U. Cohnert3, G.A. Holzapfel1,4
1Institute of Biomechanics, Graz University of Technology, Graz, Austria. 2Institute of Pathology, Medical University of Graz, Graz, Austria. 3Clinical Department of Vascular Surgery, Medical University of Graz, Graz, Austria. 4Faculty of Engineering Science and Technology, Norwegian University of Science and Technology, Trondheim, Norway.
O1377 Thrombus Promotes Vessel Wall Oxygen Starvation in Abdominal Aortic Aneurysms Sudharsan Madhavan1, Robert Peattie2,1, Robert Fisher3, Erica Kemmerling1
1Tufts University, Medford, MA, USA. 2Tufts Medical Center, Boston, MA, USA. 3Massachusetts Institute of Technology, Cambridge, MA, USA.
O1375 Ultrasound-based Biomechanical Modeling of Abdominal Aortic Aneurysms for Clinical Decision Support Richard G.P. Lopata1, Emiel M.J. van Disseldorp1, Niels J. Petterson1, Marcel C.M. Rutten1, Marc. R. van Sambeek2,1, Frans N. van de Vosse1
1Cardiovascular Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands., Eindhoven, Netherlands. 2Dept. of Vascular Surgery, Catharina Hospital Eindhoven, Eindhoven, Netherlands.
Cardiovascular - Arterial pulse wave mechanics and ventriculo-arterial interaction
P3535 A comparison of reduced-order computational models for central blood pressure estimation Jorge Mariscal-Harana1, Peter Charlton1, Samuel Vennin1, Arna van Engelen1, Torben Schneider2, Mateusz Florkow1,2, Hubrecht de Bliek3, Bram Ruijsink1, Israel Valverde1, Marietta Charakida1, Kuberan Pushparajah1, Spencer Sherwin4, Rene Botnar1, Jordi Alastruey1
1King's College London, London, United Kingdom. 2Philips Healthcare, Guildford, United Kingdom. 3Philips Healthcare, Best, Netherlands. 4Imperial College London, London, United Kingdom.
O1395 A numerical study of pulmonary vascular efficiency and right ventricular afterload during hypoxia induced pulmonary hypertension in mice M. Umar Qureshi1, Mansoor A. Haider1,2, Mette Olufsen1,2
1Department of Mathematics, North Carolina State University, Raleigh, USA. 2Biomathematics Graduate Program, North Carolina State University, Raleigh, USA.
P3539 An analysis on the level of truncation of arterial branching in distributed 1D models: Important determinants of pressure/flow waveforms and validity of reduced models. Fredrik E. Fossan1, Jorge M. Harana2, Jordi Alastruey2, Leif R. Hellevik1
1Norwegian University of Science and Technology (NTNU), Trondheim, Norway. 2King's College London (KCL), London, United Kingdom.
O1391 Aortic Arches after Coarctation Repair - Geometry and Haemodynamics Michael Quail1, Patrick Segers2, Vivek Muthurangu1
1University College London, London, United Kingdom. 2Gent University, Gent, Belgium.
P3541 Aortic cross-clamping during vascular surgery analyzed by the diastolic time-constant of arterial pressure waves Jeanne Ventre1, Maria Teresa Politi2, Juan Manuel Fernández2, Arthur Ghigo3, Sandra Wray4, Julien Gaudric5, Ismaïl Khelifa5, Ricardo Armentano6, Pierre-Yves Lagrée1, Claudia Capurro2, José María Fullana1
1Sorbonne Universités, UPMC Univ Paris06, CNRS, UMR7190, Institut Jean Le Rond d’Alembert, Paris, Argentina. 2Laboratorio de Biomembranas. Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO Houssay). Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina. 3Institut de Mécanique des Fluides de Toulouse, Toulouse, France. 4Universidad Favaloro, Buenos Aires, Argentina. 5Hôpitaux Universitaires La Pitié-Salpêtrière, Paris, France. 6Departamento de Ingeniería Biológica, Universidad de la República, Montevideo, Uruguay.
O1397 Arterial hemodynamics in the horse: insights from a 1D arterial network model Daimé Campos1,2, Lisse Vera3, Sofie Muylle4, Nikos Stergiopulos5, Gunther van Loon3, Patrick Segers1
1Ghent University, IBiTech-bioMMeda, Ghent, Belgium. 2Cujae, Cemat, BioMec, Havana, Cuba. 3Ghent University, Dept. of Large Animal Internal Medicine, Ghent, Belgium. 4Ghent University, Dept. of Morphology, Ghent, Belgium. 5LHTC, EPFL, Lausanne, Switzerland.
P3533 Augmentation index acts as ventricular-arterial coupling parameter but not as proxy for wave reflection magnitude Maarten Heusinkveld1, Wouter Huberts1, Joost Lumens1, Alun Hughes2, Tammo Delhaas1, Koen Reesink1
1CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands. 2Institute of Cardiovascular Science, University College London, London, United Kingdom.
P3542 Automatic identification of mechanical inhomogeneities in atherosclerotic human carotid arteries in-vivo Grigorios Marios Karageorgos1, Iason Zacharias Apostolakis1, Pierre Nauleau1, Elisa Konofagou1,2
1Department of Biomedical Engineering Columbia University, NEW YORK, USA. 2Department of Radiology Columbia University, NEW YORK, USA.
O1393 Evolution of aortic pressure and wave reflections during normal ageing: a computational study Stamatia Pagoulatou, Nikolaos Stergiopulos
Laboratory of Hemodyanmics and Cardiovascular Technology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
P3538 Improved diagnosis of cerebral vasospasm through a sensitivity analysis of a 1D cerebral circulation model Alessandro Melis1,2, Fernando Moura3, Ignacio Larrabide4, Richard Clayton5,2, Ana Paula Narata6, Alberto Marzo1,2
11. Department of Mechanical Engineering, The University of Sheffield, Sheffield, United Kingdom. 22. INSIGNEO Institute for in silico medicine, The University of Sheffield, Sheffield, United Kingdom. 34. Engineering, Modeling and Applied Social Sciences Center, Federal University of ABC, Sao Paulo, Brazil. 45. Pladema-CONICET-UNICEN, Tandil, Argentina. 53. Department of Computer Science, The University of Sheffield, Sheffield, United Kingdom. 66. University Hospital of Tours, UMR “Imagerie et Cervau”, Inserm U930, Universite` Francois-Rabelais, Tours, France.
P3534 Modelling and simulation of arterial wave reflections using difference equations Bernhard Hametner1, Laura Lotteraner1,2, Siegfried Wassertheurer1
1AIT Austrian Institute of Technology, Vienna, Austria. 2Vienna University of Technology, Vienna, Austria.
O1396 Modelling arterial pulse wave propagation during healthy ageing Peter Charlton1, Jorge Mariscal Harana1, Samuel Vennin1, Marie Willemet2, Phil Chowienczyk1, Jordi Alastruey1
1King's College London, London, United Kingdom. 2Nokia Technology, Paris, France.
P3537 Numerical assessment and comparison of pulse wave velocity methods aiming at measuring aortic stiffness Hasan OBEID1,2, Gilles SOULAT3, Elie MOUSSEAUX3, Stephane LAURENT4, Nikos STERGIOPULOS5, Pierre BOUTOUYRIE2, Patrick SEGERS1
1bioMMeda – Institute Biomedical Technology, Ghent University, Ghent, Belgium. 2Inserm U970, Paris Descartes University, Paris, France. 3Hôpital Européen Georges Pompidou- bDepartment of Radiology, Paris, France. 4dInserm U970, Paris-Descartes University, Paris, France. 5cLaboratory of Hemodynamics and Cardiovascular Technology, Ecole Polytechnique Fédérale de Lausanne EPFL, Lausanne, Switzerland.
P3540 Regional and local aortic pulse wave velocity in rats depend on heart rate and blood pressure Bart Spronck1,2,3, Isabella Tan1, Koen D. Reesink2, Dana Georgevsky1, Tammo Delhaas2, Alberto P. Avolio1, Mark Butlin1
1Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia. 2Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands. 3Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, CT, USA.
O1394 Tackling a clinical conundrum: the effect of repaired aortic coarctation on arterial hemodynamics and ventriculo-arterial interactions Elena G Milano1,2, Froso Sophocleous3, Sandra Neumann3, Chiara Bucciarelli-Ducci3,1, Massimo Caputo3,1, Giovanni Biglino3,4
1University Hospitals Bristol, Bristol, United Kingdom. 2University of Verona, Verona, Italy. 3University of Bristol, Bristol, United Kingdom. 4Great Ormond Street Hospital for Children, London, United Kingdom.
P3532 The Alterations of the cardiac hemodynamic in elders changing posture from the head-up to head-down tilt Ming Yun Sun1, Wen Sheng Huang2, Ya Ling Bao2, Xiao Wu He2, Nian En Yang1, Duo Qi Zhou1, Lei Lu1, Yu Hua Zhou1, Bai Ren Du1, Zhen Yu Qian1, Shu jun Zhang1
1Institute of Physical Education, Anqing Normal University, AnQing, China. 2Department of Cardio-cerebrovascular Internal Medicine , the PLA Navy Anqing Hospital, AnQing, China.
P3530 The low frequency signal of vasomotion is induced by the variation of heart period Suhong Liu, Tianxi Chi, Yang Liu
Department of Mechanical Engineering, The Hong Kong Polytechnic University, Hongkong, Hong Kong.
P3531 Understanding the role of blood pressure, wall shear stress and arterial wall stiffness in flow mediated dilation: A computational and in-vivo study Weiwei Jin1, Phil Chowienczyk2, Jordi Alastruey1
1Department of Biomedical Engineering, King's College London, London, United Kingdom. 2King’s College London British Heart Foundation Centre, Department of Clinical Pharmacology, London, United Kingdom.
O1392 Ventricular wave reflection and its effects on outflow patterns and external work Jonathan Mynard1,2,3, Joseph Smolich1,2
1Murdoch Children's Research Institute, Melbourne, Australia. 2University of Melbourne, Melbourne, Australia. 3Royal Children's Hospital, Melbourne, Australia.
Cardiovascular - Arterial stiffness and disease
P4567 4D Flow MRI Pulse Wave Velocity for Assessing Arterial Stiffness – In Vitro Validation Timothy Ruesink1, Rafael Medero1, Klarka Mendrisova1, Alejandro Roldán-Alzate1,2,3
1Mechanical Engineering, University of Wisconsin Madison, Madison, USA. 2Radiology, University of Wisconsin Madison, Madison, USA. 3Biomedical Engineering, University of Wisconsin Madison, Madison, USA.
O1805 A new method for non-invasive measurement of arterial wave speed, intensity and reflection Ethan Rowland, Kai Riemer, Kevin Lichtenstein, Mengxing Tang, Peter Weinberg
Imperial College, London, United Kingdom.
O1811 A structure-based constitutive model of arterial tissue Alexander Rachev1,2, Tarek Shazly1
1University of South Carolina, College of Engineering and Computing, Biomedical Engineering Program, Columbia, USA. 2Institute of Mechanics, Sofia, Bulgaria.
P4570 Altered adventitial collagen fibril mechanics and morphology in patients with high pulse wave velocity Zhuo Chang1, Paolo Paoletti1, Steve Barrett1, Ya Hua Chim1, Maria Lyck Hansen2, Hans Christian Beck2, Lars Melholt Rasmussen2, Riaz Akhtar1
1University of Liverpool, Liverpool, United Kingdom. 2University of Southern Denmark, Odense, Denmark.
P4568 Arterial ageing in middle-aged subjects: initial insights from follow-up measurements in the Asklepios study Daimé Campos1,2, Marc De Buyzere1, Julio Chirinos3, Ernst Rietzschel1, Patrick Segers1
1Ghent University, Gent, Belgium. 2CUJAE, Havana, Cuba. 3University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
P4572 Biomechanical Changes in the Porcine Abdominal Aorta after Treatment with Pentagalloyl Glucose Senol Piskin1, Sourav Patnaik1, Miguel Guerrero1, Gladys Escobar2, Eugene Sprague2, Ender Finol1
1University of Texas at San Antonio, San Antonio, USA. 2University of Texas Health at San Antonio, San Antonio, USA.
O1810 Characterization of the Mechanical Behavior and Microstructural Properties of Partially Ligated Common Carotid Arteries from Wild Type Mice Anastassia Pokutta-Paskaleva1, Luke Brewster2,1, Rudy Gleason1
1Georgia Institute of Technology, Atlanta, USA. 2Emory University, Atlanta, USA.
O1806 Coupling between the micro-structure of the cerebral aneurysm wall and its stiffness and failure properties Anne Robertson1, Sepideh Amin-Hanjani2, Khaled Aziz3, Juan R. Cebral4, Fady Charbel2, Ronald Fortunato1, Juhana Frösen5, Piyusha Gade1, Behnam Rezai Jahromi6, Spandan Maiti1, Mika Niemelä6, Chao Sang1, Yasutaka Tobe1, Riikka Tulamo6, Alexander Yu3, Richard Williamson3
1University of Pittsburgh, Pittsburgh, USA. 2University of Illinois at Chicago, Chicago, USA. 3Allegheny General Hospital, Pittsburgh, USA. 4George Mason University, Fairfax, USA. 5Kuopio University Hospital, Kuopio, Finland. 6Helsinki University Hospital, Helsinki, Finland.
O1809 Elastin deficiency affects arterial stiffness in aged mice Jie Hawes, Robert Mecham, Jessica Wagenseil
Washington University in St. Louis, St. Louis, USA.
P4571 Friction characterization between catheters and vascular tissue for Newtonian and non-Newtonian fluids Rosaire Mongrain1, Zinan He1, Hossein Mohammadi1, Jennifer Frattolin1, Gilles Soulez2
1McGill University, Montreal, Canada. 2University of Montreal, Montreal, Canada.
P4565 Intrinsic stiffness of the carotid arterial wall is not increased in hypertensives compared to normotensives: validation using shear wave elastography Louise Marais1,2, Mathieu Pernot3, Hakim Khettab1, Mickaël Tanter3, Emmanuel Messas1, Mustapha Zidi2, Stéphane Laurent1, Pierre Boutouyrie1
1INSERM U970 - PARCC - Hôpital Européen Georges Pompidou, Paris, France. 2EA 7377 - BIOTN - Université Paris-Est Créteil, Créteil, France. 3Institut Langevin - ESPCI-ParisTech - CNRS UMR 7587 - INSERM U979, Paris, France.
P4566 Model-based prediction of changes in geometry and mechanical properties of arteries due to progressive elastin degradation Alexander Rachev1,2, Tarek Shazly1, Nikolaos Stergiopulos3
1University of South Carolina, College of Engineering and Computing, Biomedical Engineering Program, Columbia, USA. 2Institute of Mechanics, Sofia, Bulgaria. 3Laboratory of Hemodynamics and Cardiovascular Technology, Swiss Federal Institute of Technology, Lausanne, Switzerland.
O1807 NON-CONTACT LOCAL PULSE WAVE VELOCITY ESTIMATION ON IN-VITRO NECK MODELS Daniela Tommasin1, Yanlu Li2,3, Jonathan Reeves4,5, Roel Baets2,3, Patrick Segers1, Stephen Greenwald4
1IBiTech-bioMMeda, Ghent University, Ghent, Belgium. 2Photonics Research Group, INTEC -department, Ghent University -IMEC, Ghent, Belgium. 3Center for Nano- and Biophotonics, Ghent, Belgium. 4Blizard Institute, Queen Mary University of London, London, United Kingdom. 5Clinical Physics, Barts Health Trust, London, United Kingdom.
O1808 Normal aging induces altered cardiac function, hemodynamics, and central artery stiffness in mice independent of hypertension Jacopo Ferruzzi1,2, Alexander W. Caulk1, Duane Madziva1, Guangxin Li3, George Tellides3,4, Jay D. Humphrey1,4
1Department of Biomedical Engineering, Yale University, New Haven, CT, USA. 2Department of Biomedical Engineering, Boston University, Boston, MA, USA. 3Department of Surgery, Yale University School of Medicine, New Haven, CT, USA. 4Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA.
Cardiovascular - Atherosclerotic plaque: Mechanism and modelling
O0577 A novel apparatus for the multifaceted evaluation of human brachial artery functions through transmural pressure manipulation: Toward early-stage diagnosis of atherosclerosis Takeo Matsumoto1,2, Toshiyuki Yaguchi2,3, Yalin Cong2, Kenji Shimo2, Takahiro Kurokawa2, Shukei Sugita2, Kazuaki Nagayama2,4, Hiroshi Masuda5
1Nagoya University, Nagoya, Japan. 2Nagoya Institute of Technology, Nagoya, Japan. 3Tokyo Denki University, Hatoyama, Japan. 4Ibaraki University, Hitachi, Japan. 5UNEX Corporation, Nagoya, Japan.
O0580 Biomechanical Identification of Atherosclerotic Plaque Rupture Initiation and Propagation Ali Akyildiz1, Daniel Rutten2, Ronald van den Berg2, Frank Gijsen1
1Erasmus Medical Center, Rotterdam, Netherlands. 2Delft University of Technology, Delft, Netherlands.
P1543 Calcification Volume Reduces Stretch Capability and Predisposes Plaque toRupture in: An in vitro Model of Carotid Artery Mechanical Mechanisms Hilary Barrett1, Eoghan Cunnane1, Julie O'Brien2, Michael Moloney3, Eamon Kavanagh3
1Health Research Institute, School of Engineering, Bernal Institute, University of Limerick, Limerick, Ireland. 2Departments of Radiology, University Hospital Limerick, Limerick, Ireland. 3Departments of Vascular Surgery, University Hospital Limerick, Limerick, Ireland.
P1541 Combining Plaque Burden, Components and Stress/Strain Conditions for Optimal Carotid Plaque Progression and Regression Prediction Qingyu Wang1, Gador Canton2, Kristen L Billiar3, Thomas S. Hatsukami4, Zheyang Wu5, Chun Yuan6, Dalin Tang1,5
1School of Biological Science & Medical Engineering, Southeast University, Nanjing, 210096, China. 2Department of Mechanical Engineering, University of Washington, Seattle, WA 98195, USA. 3Biomedical Engineering Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA. 4Division of Vascular Surgery, University of Washington, Seattle, WA 98195, USA. 5Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA. 6Department of Radiology, University of Washington, Seattle, WA 98195, USA.
P1539 Compressive stiffness of human coronary arteries in the development of atherosclerosis: an atomic force microscopy study Alireza Rezvani-Sharif1,2, Mohammad Tafazzoli-Shadpour2, Amirnader Emami Razavi3, Alberto Avolio1
1Macquarie University, Sydney, Australia. 2Amirkabir University of Technology, Tehran, Iran, Islamic Republic of. 3Tehran University of Medical Sciences, Tehran, Iran, Islamic Republic of.
P1545 Ex-vivo arteries components involved in thrombus formation Simona Seminati1, Marco Piola1, Maria Lombardi2, Gianfranco Beniamino Fiore1, Chiara Foglieni2, Monica Soncini1
1Department of Electronics, Informatics and Bioengineering, Politecnico di Milano, Milano, Italy. 2Cardiovascular Research Area, IRCCS San Raffaele Scientific Institute, Milano, Italy.
P1546 FSI modeling of an atherosclerotic murine carotid artery instrumented with a blood flow-modifying cuff Miten B. Patel1, Fotios Savvopoulos1, Ranil de Silva1, Vikram V. Mehta1, Avinash Kondiboyina1, Caleb C. Berggren2, Lydia Aslanidou3, Lucas H. Timmins4, Rob Krams1, Ryan M. Pedrigi2
1Imperial College London, London, United Kingdom. 2University of Nebraska-Lincoln, Lincoln, USA. 3École polytechnique fédérale de Lausanne, Lausanne, Switzerland. 4University of Utah, Salt Lake City, USA.
O0578 Multi-Risk-Factor Decision-Making Strategy May Lead to Improved Coronary Plaque Burden Increase Prediction: A Patient-Specific 3D FSI Study Using IVUS Follow-Up Liang Wang1,2, Dalin Tang1,2, Akiko Maehara3, Zheyang Wu2, Chun Yang2, David Muccigrosso4, Jie Zheng4, Kristen Billiar5, Jian Zhu6, Genshan Ma6, Gary Mintz3
1School of Biological Science and Medical Engineering, Southeast University, Nanjing, China. 2Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, USA. 3Cardiovascular Research Foundation, New York, USA. 4Mallinckrodt Institute of Radiology, Washington University, St. Louis, USA. 5Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, USA. 6Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing, China.
O0581 On modelling patient-specific carotid atherosclerotic plaque formation and development Patricia Hernández1, Myriam Cilla2,3,4, Miguel A. Martínez1,4, Estefania Peña1,4
1Aragon Institute of Engineering Research, Mechanical Engineering Department. University of Zaragoza, Zaragoza, Spain. 2Centro Universitario de la Defensa. Academia General Militar, Zaragoza, Spain. 3Aragon Institute of Engineering Research. University of Zaragoza, Zaragoza, Spain. 4CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain, Zaragoza, Spain.
P1544 Phase shifts of radial and longitudinal displacements along the carotid atheromatous plaque from B-mode ultrasound images in asymptomatic subjects with high and low stenosis lesions Spyretta Golemati1,2, Eleni Patelaki1, Aimilia Gastounioti3, Konstantina Nikita1
1National Technical University of Athens, Athens, Greece. 2National and Kapodistrian University of Athens, Athens, Greece. 3University of Pennsylvania, Philadelphia, USA.
O0582 Plaque structural stress in the coronary atherosclerosis: a potential biomarker in predicting myocardial infarction Zhongzhao Teng1,2, Adam Brown3, Stephen Hoole4, Nick West4, Martin Bennett3, Jonathan G1
1Department of Radiology, University of Cambridge, Cambridge, United Kingdom. 2Department of Engineering, University of Cambridge, Cambridge, United Kingdom. 3Division of Cardiovascular Medicine, University of Cambridge, Cambridge, United Kingdom. 4Department of Interventional Cardiology, Papworth Hospital NHS Trust, Cambridge, United Kingdom.
P1540 Rupture-induced geometry of carotid atherosclerotic plaque with intraplaque hemorrhage: Finite element study Hiroshi Yamada1, Hamed Esmaeili Monir1, Omi Senju2, Toshiyasu Ogata2, Tooru Inoue2, Noriyuki Sakata2
1Kyushu Institute of Technology, Kitakyushu, Japan. 2Fukuoka University, Fukuoka, Japan.
P1542 Stenosis in renal arteries – a numerical study Alexander Fuchs, Niclas Berg, Lisa Prahl Wittberg
KTH (Royal Institute of technology), Department of Mechanics, Stockholm, Sweden.
Cardiovascular - Beyond vFFR: Emerging clinical applications of multiscale vascular biomechanics
O0790 Closed-loop lumped parameter model for hepatic and systemic hemodynamics including different vascular regulatory mechanisms. Chloe Audebert1,2, Noemie Boissier3,4,5, Lorena Romero Medrano3,4, Eric Vibert6,7, Dirk Drasdo3,4, Irene E. Vignon-Clementel8,4
1Inria Grenoble-Rhône-Alpes, Lyon, France. 2ICJ, Univ. Lyon 1, Lyon, France. 3Inria Paris, MAMBA, Paris, France. 4Sorbonne Univ. LJLL, Paris, France. 5Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany. 6Centre hépato-biliaire, hôpital Paul-Brousse, Villejuif, France. 7Inserm U1993, Villejuif, France. 8Inria Paris, REO, Paris, France.
P2598 Generating Patient Specific Blood Flow Simulations through Analysis of Contrast Motion during Cardiac Catheterization Stephen Moore1, Sergiy Zhuk2, Vikas Thondapou3, Kerry Halupka1
1IBM Research, Melbourne, Australia. 2IBM Research, Dublin, Ireland. 3University of Melbourne, Melbourne, Australia.
P2596 Model complexity reduction for computational fractional flow reserve in coronary arteries Kujtim Gashi1, Marielle Bosboom1, Marcel van 't Veer2, Sjeng Quicken3, Wouter Huberts3, Frans van de Vosse1
1Eindhoven University of Eindhoven, Eindhoven, Netherlands. 2Catharina Hospital Eindhoven, Eindhoven, Netherlands. 3Maastricht University, Maastricht, Netherlands.
O0792 Physiological measures of mechanical stimuli derived from coronary CTA in saphenous vein grafts with and without stenosis M. Owais Khan1, René Packard2, Ronald Karlsberg3,4, Andrew Kahn5, Alison Marsden1
1Stanford University, Stanford, USA. 2University of California Los Angeles, Los Angeles, USA. 3Cardiovascular Research Foundation of Southern California, Los Angeles, USA. 4Heart Institute - Cedars-Sinai, Los Angeles, USA. 5University of California San Diego, San Diego, USA.
O0788 Quantifying Blood Flow and Pressure in the Coronary Arteries of Patients with Nonobstructive Coronary Artery Disease Charles Taylor1, Jonathon Leipsic2, Bjarne Nørgaard3
1HeartFlow, Inc., Redwood City, USA. 2Department of Radiology and Division of Cardiology, St. Paul’s Hospital, Vancouver, Canada. 3Department of Cardiology, Aarhus University Hospital Skejby, Aarhus, Denmark.
P2595 Real-Time Patient-Specific Transaortic Pressure Gradient Computation from Parameterized Aortic Valve Geometries Martijn Hoeijmakers1,2, Michel Rochette2, Jürgen Weese3, Rod Hose4, Frans van de Vosse1
1Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands. 2ANSYS Inc., Lyon, France. 3Philips Research Laboratories, Hamburg, Germany. 4Medical Physics Group, University of Sheffield, Sheffield, United Kingdom.
P2594 Virtual Fractional Flow Reserve derived from Computed Tomographic Angiography By Using a Vessel Length Method Kyung Eun Lee1, Eun-Seok Shin2, Eun Bo Shim1
1Kangwon National University, Chuncheonsi, Korea, Republic of. 2University of Ulsan College of Medicine, Ulsan, Korea, Republic of.
O0789 What is needed to make cardiovascular models suitable for clinical decision support? Wouter Huberts1,2, Stefan Heinen3, Niek Zonnebeld1, Daniel van den Heuvel3, Jean-Paul de Vries3, Jan Tordoir1, Rod Hose4, Tammo Delhaas1, Frans van de Vosse2
1Maastricht University Medical Center, Maastricht, Netherlands. 2Eindhoven University of Technology, Eindhoven, Netherlands. 3Sint Antonius Hospital Nieuwegein, Nieuwegein, Netherlands. 4Sheffield University, Sheffield, United Kingdom.
Cardiovascular - Biomechanics of cardiovascular tissues
O0239 A constituent specific study of damage accumulation in arterial tissue Milad Ghasemi1,2, David Nolan1,2, Caitríona Lally1,2
1Trinity Centre for Bioengineering, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland. 2Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Dublin, Ireland.
P1570 A numerical method for the implementation of discrete fibre dispersion Catherine O'Connor, Eoin McEvoy, Patrick McGarry
National University of Ireland Galway, Galway, Ireland.
O0241 A One Fiber Family Constitutive Model of the Right Pulmonary Artery Erica Pursell1,2, Daniela Valdez-Jasso1,2
1University of Illinois at Chicago, Chicago, USA. 2University of California San Diego, San Diego, USA.
P1567 A rapid and accurate assessment of aortic valve leaflet curvature Daniel Chaparro, Melake Tesfamariam, Sharan Ramaswamy, Joshua Hutcheson
Florida International University, Miami, USA.
O0020 Application of Digital Image Correlation to determine the multiaxial mechanical properties of ascending, descending and abdominal porcine aorta. Juan A Peña1, Miguel A Martínez2,3, Estefania Peña2,3
1Aragon Institute of Engineering Research, Department of Management and Manufacturing Engineering,. University of Zaragoza, Zaragoza, Spain. 2Aragon Institute of Engineering Research, Mechanical Engineering Department. University of Zaragoza, Zaragoza, Spain. 3CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain, Zaragoza, Spain.
P1564 Artificial Neural Networks to Characterize the Mechanical Response of Soft Biological Tissues Myriam Cilla1,2, Ignacio Pérez-Rey3, Miguel Angel Martínez1, Estefanía Peña1, Javier Martínez3,4
1Aragon Institute of Engineering Research (I3A). University of Zaragoza, Zaragoza, Spain. 2Centro Universitario de la Defensa. Academia General Militar, Zaragoza, Spain. 3Department of Natural Resources and Environmental Engineering. University of Vigo, Vigo, Spain. 4Centro Universitario de la Defensa (CUD). Escuela Naval Militar, Marín, Spain.
P1566 Biaxial mechanical testing of human pericardium to inform surgical reconstruction of heart valves Sophie C Hofferberth, David M Hoganson, Pedro J del Nido, Peter E Hammer
Department of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, USA.
P1559 Biomechanical assessment of mitral valve myxomatous leaflets tissue Omar Antonio Pappalardo1,2, Matteo Selmi2,1, Yasmine L. Hiemstra3, Boudewijn Kruithof4, Martin J. Schalij3, Giuseppe Faggian2, Nina AJMONE MARSAN3, Emiliano Votta1
1Politecnico di Milano, DEIB, Milano, Italy. 2Università di Verona, Division of Cardiac Surgery, Verona, Italy. 3Leiden University Medical Center, Department of Cardiology, Leiden, Netherlands. 4Leiden University Medical Center, Leiden, Netherlands.
P1555 Bovine Pericardium Durability, Stiffness, and Ultimate Tensile Strength are Governed by Collagen Fibre Orientation and Dispersion Alison Whelan1,2,3, John Duffy1,2, Paul Gunning4, David Nolan1,2, Bruce Murphy1,2, Caitriona Lally1,2
1Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. 2Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Dublin, Ireland. 3Structural Heart, Boston Scientific Corporation, Galway, Ireland. 4Structural Heart, Boston Scientific Corporation, Los Gatos, USA.
P1552 Cardiac muscle samples working against a real-time model of the vasculature dynamic impedance Amy Garrett, Toan Pham, Denis Loiselle, June-Chiew Han, Andrew Taberner
The University of Auckland, Auckland, New Zealand.
O0244 Changes in the material properties of aorta due to trauma Kurosh Darvish, Ali Hemmasizadeh, Soroush Assari
Temple University Biomechanics Lab, Philadelphia, USA.
P1557 Comparative mechanical, morphological, and microstructural properties of the mitral and tricuspid valve leaflets and chordae tendinae Fatiesa Sulejmani1, Anastassia Pokutta-Paskaleva1, Marissa DelRocini2, Wei Sun1
1The Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Atlanta, USA. 2Department of Biomedical Engineering, Rutgers, The State University of New Jersey,, Piscataway, USA.
P1549 Computational Study of Altered Pressure induced Arterial Remodeling Shijia Zhao1, Linxia Gu2
1University of Nebraska Medical Center, Omaha, USA. 2University of Nebraska, Lincoln, USA.
O0126 Determination of In-Vivo Mechanical Properties in Lower Extremity Arteries Rossella Colli1, Francesco Migliavacca1, Scott Berceli2, Jose F Rodriguez Matas1
1Politecnico di Milano, Milano, Italy. 2University of Florida, Gainesville, USA.
P1562 Development of a polyvinyl alcohol viscoelastic aortic reconstruction graft Christopher Zikry1,2, Raymond Cartier2,3, Gilles Soulez4, Rosaire Mongrain5,2
1Department of Biomedical Engineering, McGill University, Montreal, Canada. 2Research Center, Montreal Heart Institute, Montreal, Canada. 3Department of Cardiac Surgery, Montreal Heart Institute, Montreal, Canada. 4Département de Radiologie, Radio-Oncologie et Médecine Nucléaire, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, Canada. 5Department of Mechanical Engineering, McGill University, Montreal, Canada.
P1558 Effect of atrial fibrillation on the biomechanical properties of the left atrial appendage Giampaolo Martufi1,2, David Schwartzman3, Federica Boschetti4, Elena S. Di Martino2
1Royal Institute of Technology, Stockholm, Sweden. 2University of Calgary, Calgary, Canada. 3University of Pittsburgh, Pittsburgh, USA. 4Politecnico di Milano, Milan, Italy.
P1563 Estimating material properties of stenosed arteries using ultrasound functional imaging in combination with finite element modeling Joerik de Ruijter1,2, Frans van de Vosse1, Marc van Sambeek2,1, Richard Lopata1
1Eindhoven University of Technology, Eindhoven, Netherlands. 2Catharina Hospital, Eindhoven, Netherlands.
P1553 Extracellular matrix micromechanics of zebrafish heart Anna Garcia-Puig1,2, Ignasi Jorba3,4, Daniel Navajas3,4,5, Ángel Raya1,2,6
1Center of Regenerative Medicine in Barcelona (CMRB), Barcelona, Spain. 2Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. 3Institute for Bioengineering of Catalonia, Barcelona, Spain. 4Unit of Biophysics and Bioengineering, University of Barcelona, Barcelona, Spain. 5CIBER de Enfermedades Respiratorias, Madrid, Spain. 6Center for Networked Biomedical Research on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.
O0125 Finite element implementation of growth induced three-dimensional residual stress in the aortic wall Haofei Liu1, Ming Zhang1, Minliang Liu2, Caitlin Martin2, Wei Sun2
1Tianjin University, Tianjin, China. 2Georgia Institute of Technology, Atlanta, USA.
O0240 Fracture behaviour and microstructure-mechanics relationship of human aortic aneurysms Aziz Tokgoz1, Shuo Wang2, Priya Sastry3, Chang Sun2, Nichola Figg3, Martin R. Bennett3, Sanjay Sinha3, Jonathan H. Gillard2, Michael P. F. Sutcliffe1, Zhongzhao Teng2,1
1Department of Engineering, University of Cambridge, Cambridge, United Kingdom. 2Department of Radiology, University of Cambridge, Cambridge, United Kingdom. 3Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
O0021 Identification of regional mechanical properties in murine thoracic aortic aneurysms Matthew R. Bersi1,2, Chiara Bellini3,2, Jay D. Humphrey2, Stéphane Avril4
1Vanderbilt University, Nashville, USA. 2Yale University, New Haven, USA. 3Northeastern University, Boston, USA. 4École des Mines de Saint-Étienne, Saint-Étienne, France.
O0245 Impact of assumption of affine deformation on constitutive models of arterial tissue Martin Slazansky1, Stanislav Polzer2, Jiri Bursa1
1Institute of Solid Mechanics, Mechatronics and Biomechanics, Faculty of Mechanical Engineering, Brno University of Technology, Brno, Czech Republic. 2Department of Applied Mechanics, Faculty of Mechanical Engineering, VSB – Technical University of Ostrava, Ostrava, Czech Republic.
O0127 Machine-learning investigation of relationship between strength and response features in ascending thoracic aneurysm tissue Yuanming Luo1, Zhiwei Fan2, Stephen Baek1, Jia Lu1
1The University of Iowa, Iowa City, IA, USA. 2University of Wisconsin-Madison, Madison, WI, USA.
P1569 Measurements of delamination characteristics of thoracic aortic tissue in glycation process Shohei Nakagawa, Takeshi Moriwaki, Kazuhiro Fujisaki, Kazuhiko Sasagawa
Department of Intelligent Machines and System Engineering, Hirosaki University, Hirosaki, Japan.
P1556 Mechanical and visual assessment of uniaxial experimental parameters and their effect on bovine pericardial tissue. Karl Joyce1,2, Yury Rochev1, Sohail Rahmani2
1School of Chemistry, National University of Ireland, Galway, Ireland. 2Boston Scientific, Galway, Ireland.
P1554 Mechanical characterization and numerical modeling of porcine aortic valve tissues Colin Laville, Yannick Tillier
CEMEF Centre de Mise en Forme des Matériaux MINES ParisTech, PSL Research University, Sophia Antipolis, France.
P1560 Mechanisms of vascular endothelial denudation during balloon angioplasty Xiuyu WANG, Olga CHASHCHINA, Belén Rodríguez García, Abdul BARAKAT
Ecole Polytechnique, Palaiseau, France.
O0018 Microscopic deformation of the aorta during pressurization based on SHG and two-photon microscopy Shukei Sugita1, Masaya Katoh1, Masanori Nakamura1, Takeo Matsumoto2,1
1Nagoya Institute of Technology, Nagoya, Japan. 2Nagoya University, Nagoya, Japan.
O0122 Multiscale and multiaxial mechanics of vascular smooth muscle contractility Sae-Il Murtada1, Jay Humphrey1, Gerhard Holzapfel2,3
1Yale University, New Haven, USA. 2Graz University of Technology, Graz, Austria. 3Norwegian University of Science and Technology, Trondheim, Norway.
O0237 Numerical modeling of rupture in human arterial walls Osman Gültekin1, Hüsnü Dal2, Gerhard Holzapfel1,3
1Institute of Biomechanics, TU Graz, Graz, Austria. 2Mechanical Engineering Department, METU, Ankara, Turkey. 3Faculty of Engineering Science and Technology, NTNU, Trondheim, Norway.
O0123 On a three-dimensional mechano-electrochemical model for smooth muscle contraction Robert Seydewitz1, Enrique Morales1, Tobias Siebert2, Markus Böl1
1Institute of Solid Mechanics, Braunschweig, Germany. 2Institute of Sport and Motion Science, Stuttgart, Germany.
P1548 Peel studies on diseased thoracic aortic dissections Anju R. Babu1, Namrata Gundiah2
1University of Oklahoma, Norman, USA. 2Indian Institute of Science, Bangalore, India.
O0243 Postnatal melatonin treatment improves compliance of conductance arteries in chronic hypoxic lambs Eugenio Rivera1, Claudio Garcia-Herrera1, Daniel Cañas1, Emilio Herrera2
1Universidad de Santiago de Chile, Santiago, Chile. 2Universidad de Chile, Santiago, Chile.
P1568 Predicting individual aortic tissue material behaviour: Does patient specific characterization matter? Miriam Nightingale1,2,3, Michel Labrosse4, Elena Di Martino5,2,3
1The Biomedical Engineering Graduate Program, Calgary, Canada. 2Libin Cardiovascular Institute of Alberta, Calgary, Canada. 3University of Calgary, Calgary, Canada. 4University of Ottawa, Ottawa, Canada. 5Centre for Bioengineering Research and Education, Calgary, Canada.
P1572 Shear strain in the carotid artery of young and elderly subjects using B-mode ultrasound: a pilot study Spyretta Golemati1, Demosthenes Cokkinos2, Spyros Zakynthinos1
1National Kapodistrian University of Athens, Athens, Greece. 2Evangelismos Hospital, Athens, Greece.
P1551 Small amplitude oscillations of a damaged Demiray tube under pressure Kriti Arya, Somnath Sarangi
Indian Institute of Technology Patna, Depratment of Mechanical Engineering, Bihta, Patna, India.
P1550 The mechanical characterisation of bovine embolus analogues under various loading conditions. Fiona Malone1, Paul Fahy1, James Kennedy2,3, Andrew Fagan4, Liam Morris1
1GMedTech, Department of Mechanical and Industrial Engineering, Galway-Mayo Institute of Technology, Galway, Ireland. 2Materials Research Institute, Athlone Institute of Technology, Athlone, Ireland. 3Mazars, Harcourt Centre, Block 3, Harcourt Road, Dublin 2, Ireland. 4National Centre for Advanced Medical Imaging, St. James’s Hospital / School of Medicine, Trinity College, Dublin, Ireland.
O0017 Unravelling the aortic microstructure: synchrotron-based quasi-static pressure inflation of the mouse carotid artery Bram Trachet1,2, Mauro Ferraro1, Lydia Aslanidou1, Patrick Segers2, Nikolaos Stergiopulos1
1EPFL, Lausanne, Switzerland. 2Ghent University, Ghent, Belgium.
Cardiovascular - Biomechanics of the Cardiovascular System: The Tarbell effect (John Tarbell 70th birthday session)
O1012 Biomechanics of the Vascular System: The Role of the Glycocalyx Eno Ebong1,2, Solomon Mensah1, Ian Harding1, Ming Cheng1
1Northeastern University, Boston, USA. 2Albert Einstein College of Medicine, New York, USA.
O1009 The exquisit design of the endothelial glycocalyx and its amazing application to a jet ski train Sheldon Weinbaum1, Yiannis Andreopoulos1, Quinhong Wu2, Parisa Mirbod3
1The City College of New York, CUNY, New York, USA. 2Villamova University, Villanova, USA. 3Clarkson University, Potsdam, USA.
Cardiovascular - Cardiac growth and remodelling mechanics
O0805 A finite element implementation of growth and remodeling based on the homogenized constrained mixture model S. Jamaleddin Mousavi1,2,3, Stéphane Avril1,2,3
1Mines Saint-Etienne, CIS-EMSE, F-42023, Saint-Etienne, France. 2INSERM, U1059, SAINBIOSE, F-42023, Saint-Etienne, France. 3Université de Lyon, F-69000, Lyon, France.
O0807 A microstructure-based model of passive myocardial mechanics Abdallah Hasaballa1, Vicky Wang1, Gregory Sands1, Alexander Wilson1, Alistair Young1,2, Ian LeGrice3,1, Martyn Nash4,1
1Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand. 2Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand. 3Department of Physiology, The University of Auckland, Auckland, New Zealand. 4Department of Engineering Science, University of Auckland, Auckland, New Zealand.
P2601 A novel multiscale model of cardiac hypertrophy incorporating intracellular signaling Ana Estrada, Matthew Sutcliffe, Colleen Witzenburg, Jeffrey Saucerman, Jeffrey Holmes
University of Virginia, Charlottesville, USA.
O0806 Pathophysiological micro-mechanical viscoelastic properties of developing, ageing and infarcted myocardium Giorgio Mattei1,2,3, Saskia Maas3, Daniela Salvatori3, Christine Mummery3
1Optics11 B.V., Amsterdam, Netherlands. 2Biophotonics & Medical Imaging and LaserLaB, Vrije Universiteit, Amsterdam, Netherlands. 3Department of Anatomy and Embryology, LUMC, Leiden, Netherlands.
P2603 Predicting the collagen expression levels in early aortic arches for normal and instrumented embryos Gürsan ÇOBAN, Samane Lashkari Nia, Merve Çelik, Cansu Karakaya, Erhan Ermek, A. İdil Çakıroğlu, Kerem Pekkan
koç university, istanbul, Turkey.
O0804 Significant differences in the mechanical modeling of confined growth predicted by the Lagrangian and Eulerian formulations Mahmoud Safadi1,2, Miles B. Rubin1
1Technion – Israel Institute of Technology, Haifa, Israel. 2Azrieli College of Engineering Jerusalem, Jerusalem, Israel.
P2602 The Adaptation of a Hypertrophic Heart Emanuele Rondanina, Nick van Osta, Loes van der Donk, Frans van de Vosse, Peter Bovendeerd
Eindhoven University of Technology, Eindhoven, Netherlands.
Cardiovascular - Cardiac mechanics and heart modelling
O1246 A Biomechanical Analysis of Suture Retention in Human Atrioventricular Valve Annuli Immanuel David Madukauwa-David1, Eric Pierce2, Fatiesa Sulejmani2, Joshua Pataky2, Wei Sun2, Ajit Yoganathan2
1George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, USA. 2Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, USA.
P3560 A novel imaged-based approach for tricuspid valve biomechanical evaluation through finite element modeling Matteo Selmi1,2, Omar Antonio Pappalardo2,1, Angela Aversa2, Eleonora Careddu2, Michal Jaworek2, Riccardo Vismara2, Giovanni Battista Luciani1, Giuseppe Faggian1, Alberto Redaelli2, Emiliano Votta2
1Division of Cardiac Surgery, Department of Surgery, Università di Verona, Verona, Italy. 2Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy.
P3548 An in-vitro assessment of blood clot trajectory pattern through patient specific vasculature under various flow conditions Fiona Malone1, Jan-Hendrik Buhk2, Fiehler Jens2
1GMedTech, Department of Mechanical and Industrial Engineering, Galway-Mayo Institute of Technology, Galway, Ireland. 2Imaging SC of University Medical Center Hamburg Eppendorf, Department of Diagnostic and Interventional Neuroradiology,, Hamburg, Germany.
P3557 Carbonylation extends attached state of atrial myosin. Daniil Shchepkin, Galina Kopylova, Salavat Nabiev, Sergey Bershitsky
Institute of Immunology and Physiology, Russian Academy of Sciences, Yekaterinburg, Russian Federation.
O1251 Cardiac resynchronization therapy simulations in virtualized heart models Baris Cansiz1, Krunoslav Sveric2, Karim Ibrahim2, Ruth Strasser2, Axel Linke2, Michael Kaliske1
1Institute for Structural Analysis, Technische Universität Dresden, Dresden, Germany. 2Department of Internal Medicine and Cardiology, Heartcenter, Technische Universität Dresden, Dresden, Germany.
P3555 Cinching the tricuspid annulus in an ex-vivo porcine model: Mechanical evaluation of the Kay procedure Fatiesa Sulejmani, Joshua Pataky, Wei Sun
The Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Atlanta, USA.
P3556 Comparison of the effect of posttranslational modifications and cardiomyopathy mutations of tropomyosin on the actin-myosin interaction in the atria and ventricles. Galina Kopylova1, Valentina Oshchepkova1,2, Alexander Matyushenko3, Sergey Bershitsky1, Daniil Shchepkin1
1Institute of Immunology and Physiology, Russian Academy of Sciences, Yekaterinburg, Russian Federation. 2Ural Federal University, Yekaterinburg, Russian Federation. 3A.N. Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, Moscow, Russian Federation.
P3544 Effect of Left Ventricular Torsional Motion on Cardiac Fluid Mechanics is Insignificant at Various Length Scales Hadi Wiputra1, Vivek Vasudevan2, Josef JR Low3, Guat Ling Lim4, Sanah Merchant Soomar5, Arijit Biswas4, Citra Nurfarah Zaini Mattar4, Hwa Liang Leo2, Choon Hwai Yap2
1National University of Singapore Graduate School for Integrated Sciences and Engineering, Singapore, Singapore. 2Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore. 3Department of Mechanical Engineering, National University of Singapore, Singapore, Singapore. 4Department of Obstetrics and Gynecology, Yong Loo Lin School of MedicineNational University Health Systems, National University of Singapore, Singapore, Singapore. 5Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
P3543 Effect of mitral valves on changes in hemodynamics in porcine left ventricles before and after a myocardial infarction Vivek Vasudevan1, Adriel Jia Jun Low1, Sarayu Parimal Annamalai2, Smita Sampath2, Chih-Liang Chin2, Choon Hwai Yap1
1Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore. 2Translational Biomarkers, Merck Research Laboratories, MSD, Singapore, Singapore.
P3561 Elastin Fiber Network Alterations in Primate Aortic Valves After Flex-Flow Exposure Brittany Gonzalez1, Alejandro Pinero1, Manuel Perez1, Ilyas Saytashev1, Maria Carla Gonzalez1, Krishna Rivas2, Pablo Morales2, Joseph Wagner2, Jessica Ramella-Roman1, Sharan Ramaswamy1
1Florida International University, Miami, USA. 2Mannheimer Foundation Inc., Homestead, USA.
O1134 Experimental investigation of the biomechanical response and the microstructure of the ventricular myocardium Gerhard Sommer1, Gerhard A. Holzapfel1,2
1Graz University of Technology, Graz, Austria. 2Norwegian University of Science and Technology, Trondheim, Norway.
P3558 Fluttering modes of bioprosthetic heart valves Silje Ekroll Jahren1, Bernhard Vennemann2,1, Thomas Rösgen2, Dominik Obrist1
1ARTORG Center, University of Bern, Bern, Switzerland. 2Institute of Fluid Dynamics, ETH Zürich, Zürich, Switzerland.
O1245 Generic registration-based pipeline for personalized cardiac flow simulations : application on 12 healthy cases Alexandre This1,2,3, Ludovic Boilevin-Kayl2,3, Hernán G. Morales1, Odile Bonnefous1, Miguel A. Fernández2,3, Jean-Frédéric Gerbeau2,3
1Medisys, Philips Research, Suresnes, France. 2INRIA Paris, Paris, France. 3Sorbonne Universités, UPMC Univ Paris 6, UMR 7598 LJLL, Paris, France.
P3546 Incorporating in vivo stress into end-diastolic geometry of left ventricle using modified backward displacement method Jiri Vaverka, Jiri Bursa
Institute of Solid Mechanics, Mechatronics and Biomechanics, Faculty of Mechanical Engineering, Brno University of Technology, Brno, Czech Republic.
P3549 In-silico study of the cardiac electrophysiology behavior of infarcted swine hearts treated with biomaterial injections William Ramírez1, Kevin Sack2, Julius M. Guccione3, Daniel Hurtado1
1Pontificia Universidad Católica de Chile, Santiago, Chile. 2University of Cape Town, Cape Town, South Africa. 3University of California San Francisco, San Francisco, USA.
P3562 Mechanical Contribution to Ventricular Arrhythmias during Acute Regional Ischemia Peter A. Baumeister1, Tarek Lawen1, Sara A. Rafferty1, Behzad Taeb1, Ilija Uzelac2, Flavio H. Fenton2, T. Alexander Quinn1,3
1Physiology & Biophysics, Dalhousie University, Halifax, Canada. 2School of Physics, Georgia Institute of Technology, Atlanta, USA. 3School of Biomedical Engineering, Dalhousie University, Halifax, Canada.
O1135 Modeling Viscoelasticity and Frequency Response in Cardiac Muscle David Nordsletten1,2, Ralph Sinkus1, Gerhard Holzapfel3,4
1King's College London, London, United Kingdom. 2University of Michigan, Ann Arbor, USA. 3TU Graz, Graz, Austria. 4NTNU, Trondheim, Norway.
P3553 Modelling myocardial infarction in the heart Hao Gao1, Xin Zhuan1, Kenneth Mangion2, Colin Berry2, Ray Ogden1, Xiaoyu Luo1
1School of Mathematics and Statistics, University of Glasgow, Glasgow, United Kingdom. 2Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow, United Kingdom.
P3564 Myocardial material parameter estimation from 2D imaging data - a feasibility study. Anastasia Nasopoulou, David Nordsletten, Steven Niederer, Pablo Lamata
King's College London, London, United Kingdom.
O1136 New model of the electromechanical coupling in human cardiomyocytes including mechano-electric feedbacks Nathalie Balakina-Vikulova1,2, Olga Solovyova1,2, Alexander Panfilov3, Leonid Katsnelson1,2
1Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation. 2Ural Federal University, Ekaterinburg, Russian Federation. 3Ghent University, Ghent, Belgium.
O1138 Numerical modeling of the electromechanical activity of the left ventricle with inclusion of the Purkinje network Christian Vergara1, Mikel Landajuela1, Antonello Gerbi2, Luca Dede'1, Luca Formaggia1, Alfio Quarteroni1
1Politecnico di Milano, Milan, Italy. 2EPF de Lausanne, Lausanne, Switzerland.
O1252 Patient-specific computational modeling of cardiac biomechanics via adjoint-based data assimilation Henrik Finsberg1,2, Gabriel Balaban3, Joakim Sundnes1,2, Marie Rognes1, Samuel Wall1,2
1Simula Research Laboratory, Oslo, Norway. 2Center for Cardiological Innovation, Oslo, Norway. 3Department of Imaging Sciences and Bioengineering, KCL, London, United Kingdom.
O1248 Patient-specific electro-mechano-fluidic models to study the impact of aortic valve disease and coarctations upon ventricular load Christoph M Augustin1,2, Gernot Plank2, Elias Karabelas2, Matthias A. F. Gsell2, Shawn C. Shadden1
1University of California, Berkeley, Berkeley, USA. 2Medical University of Graz, Graz, Austria.
O1250 Patient-Specific Finite Element Simulation of Left Ventricle Hemodynamics and Mitral Valve Disease Based on Echocardiography Frida Svelander1, David Larsson1, Didier Lucor2, Reidar Winter3, Matilda Larsson1, Johan Hoffman1
1KTH Royal Institute of Technology, Stockholm, Sweden. 2CNRS, Paris, France. 3Karolinska Institute, Stockholm, Sweden.
P3559 Personalization of Synthetic Pathological Left Ventricles using Learning-Based Infarct Localization and Finite-Element Inverse Modeling Gerardo Kenny Rumindo1, Nicolas Duchateau1, Jacques Ohayon2, Pierre Croisille1, Patrick Clarysse1
1Univ. Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, INSERM, CREATIS UMR 5220, U1206, Lyon, France. 2University Savoie Mont Blanc, Polytech Annecy-Chambéry, Laboratory TIMC-IMAG/DyCTiM2, UGA, CNRS, Grenoble, France.
P3551 Regional endocardial strains in the left ventricle enable more accurate assessment of acutely-evolving and chronic heart failure post-myocardial infarction D.S. Mansell1, V.D. Bruno2, E. Sammut2, T. Johnson2, R. Ascione2, H.S. Gill1, K.H. Fraser1, A.N. Cookson1
1University of Bath, Bath, United Kingdom. 2University of Bristol, Bristol, United Kingdom.
O1140 Regional strain analysis of the right ovine ventricle based on fiduciary markers William Meador1, Marcin Malinowski2, Tomasz Jazwiec2, Matthew Goehler2, Tomasz Timek2, Manuel Rausch1
1University of Texas at Austin, Austin, USA. 2Spectrum Health, Grand Rapids, USA.
O1244 Subject-specific biventricular finite element models of healthy and failing swine hearts from high-resolution DT-MRI Kevin Sack1,2, Eric Aliotta3, Daniel Ennis3, Jenny Choy4, Ghassan Kassab4, Julius Guccione2, Thomas Franz1
1University of Cape Town, Cape Town, South Africa. 2University of California, San Francisco, San Francisco, USA. 3University of California, Los Angeles, Los Angeles, USA. 4California Medical Innovations Institute, Inc, San Diego, USA.
P3550 The influence of the cardiac hemodynamic in public college students changing posture from the head-up to head-down tilt Duo Qi Zhou1, Ming Yun Sun1, Ya Ling Bao2, Wen Sheng Huang2, Xiao Wu He2, Nian En Yang1, Lei Lu1, Yu Hua Zhou1, Bai Ren Du1, Zhen Yu Qian1
1Institute of Physical Education, Anqing Normal University, AnQing, China. 2Department of Cardio-cerebrovascular Internal Medicine , the PLA Navy Anqing Hospital, AnQing, China.
O1139 The role of myocardium compressibility in organ-level simulations of actively contracting healthy and infarcted hearts Joao S. Soares1,2, David S. Li1, Reza Avazmohammadi1, Joseph H. Gorman III3, Robert C. Gorman3, Michael S. Sacks1
1Willerson Center for Cardiovascular Modeling and Simulation, Institute for Computational Engineering and Sciences, Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA. 2Engineered Tissue Multiscale Mechanics & Modeling Laboratory, Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, USA. 3Gorman Cardiovascular Research Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
P3552 The study on the mechanism of the “blood stolen” phenomenon Xiaoyan Zhang, Youjun Liu
College of Life Science and Bioengineering, Beijing University of Techonology, Beijing, China.
P3563 Viscoactive and anatomically accurate model of cardiac contraction: boundary conditions and validation criteria Aditya Ponnaluri1, Ilya Verzhbinsky2, Jeff Eldredge1, Alan Garfinkel3, Daniel Ennis2,4, Luigi Perotti2,4
1Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, Los Angeles, USA. 2Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, USA. 3Department of Medicine (Division of Cardiology), University of California, Los Angeles, Los Angeles, USA. 4Department of Bioengineering, University of California, Los Angeles, Los Angeles, USA.
Cardiovascular - Cardiac regeneration and healing
O1359 A bioresorbable carrier and passive stabilization device to improve heart function post-myocardial infarction Eimear Dolan*1,2, Bjorn Hofmann*3, Hamman de Vaal3, Gabriella Bellavia4, Stefania Straino4, Lenka Kovarova5, David Monahan6, Helena Kelly1,2, Stephen Wildhirt3, Garry Duffy6
1School of Pharmacy, Royal College of Surgeons in Ireland, 123 St. Stephen’s Green,, Dublin 2, Ireland. 2Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, Dublin 2, Ireland. 3AdjuCor GmbH, Lichtenbergstr. 885748, Garching, Germany. 4Explora Biotech Srl, G. Peroni 386 – 00131, Rome, Italy. 5R&D department, Contipro, Dolni Dobrouc 401, 561 02, Dolni Dobrouc, Czech Republic. 6Department of Anatomy, School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland.
O1363 Artificial myocardial muscle using 3D printed micro-fiber scaffolds with human iPS-derived cardiomyocytes Miguel Castilho1,2, Malachy Maher1, Alain van Mil1, Renée Maas1, Corina Metz1, Keita Ito1,2, Joost Sluijter1, Jos Malda1,3
1University Medical Center Utrecht | | The Netherlands, UTRECHT, Netherlands. 2Eindhoven University of Technology, Eindhoven, Netherlands. 3Utrecht University, UTRECHT, Netherlands.
P3565 Development of a nanoparticle-loaded hydrogel capable of delivering growth factor-loaded nanoparticles to the ischaemic myocardium to induce angiogenesis and reduce tissue damage Joanne O'Dwyer1,2,3, Robert Murphy4, Andreas Heise4, Garry Duffy2,5,6, Sally Ann Cryan1,2,7
1School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland. 2Tissue Engineering Research Group, RCSI, Dublin, Ireland. 3Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Iran, Islamic Republic of. 4Department of Pharmaceutical and Medicinal Chemistry, RCSI, Dublin, Ireland. 5Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland. 6Anatomy, School of Medicine, College of Medicine, Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland. 7Advanced Materials and Bioengineering Research Centre, RCSI and TCD, Dublin, Ireland.
P3567 Electrospinning decellularized aorta and heart extracellular matrix with polycaprolactone as platforms to improve cellular performance James Reid, Nimrah Munir, Anthony Callanan
Institute for Bioengineering, School of Engineering, The University of Edinburgh, Edinburgh, United Kingdom.