23 SURGICAL OUTCOMES IN PATIENTS WITH DISORDERS OF SEX DEVELOPMENT IN MOFID CHILDREN’S HOSPITAL, 2001-2014
Ahmad Khaleghnejad Tabari, Leily Mohajerzadeh, Mohsen Rouzrokh, Saran Lotfollahzadeh, Arameh Abbasian, Sareh Pourhassan
Pediatric Surgery Research Center, Research Institute for children health, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of

Abstract

Aim of the study: Disorders of Sex Development is a childhood and infantile anomaly affecting not only the somatic growth; but also leading to stress and anxiety among parents who are seeking optimal treatments. In this study the surgical outcomes in patients with Disorders of Sex Development in Mofid Children’s Hospital from 2001 to 2014 were determined.

Methods: In this case series study 72 children with Disorders of Sex Development in Mofid Children’s Hospital from 2001 to 2014 were enrolled and followed in a regular manner. Data were gathered by existing medical documents and were recorded in prepared checklist. The surgical outcomes were assessed with interview and clinical examination. The success and complication rate were determined by group of surgeons .

Main Results: Seventy two patients; 55 (76.38%) affected by Congenital Adrenal Hyperplasia, thirteen (18.05%) by Testicular Feminization , 2 (2.7%) by OvoTesticular Disorder and two case (2.7%) by Mixed Gonadal Dysgenesis,were enrolled. Most common intervention was Clitroplasty, Genitoplasty and Pullthrough Vaginoplasty (table1). Fifty nine patients (81.9%) had no surgical complications. All patients were discharged uneventfully. Three cases of Testicular Feminization (4.2%) who underwent pulltrough colovaginoplasty were married.

Conclusion: Surgical outcomes in cases of Disorders of Sex Development were relatively satisfactory. However long-term follow-up study is required to determine the final outcomes especially for marital and sexual issues.

Table 1

Mixed gonadal Dysgenesis

Ovotesticular

Testicular Feminization

CAH

Frequency

Type of surgery

1

1

-

45

47

1- Clitoro plasty+Vaginoplasty+Genitoplasty

-

-

-

9

9

2-Clitoroplasty+Genitoplasty+ colovaginoplasty

_

_

_

1

1

3- Urethroplasty+Scrotoplasty+hysterectomy+bilateral salpingo-oophorectomy

_

1

-

-

1

4- Hysterosalpangectomy+Left Gonadectomy+Right Orchidopexy

1

-

-

_

1

5-Genitoplasty+ColoVaginoplasty+Left Orchidectomy

_

_

13

_

13

6- ColoVaginoplasty+Bilateral Gonadectomy

2

2

13

55

72

Total

 

 

 

 

 

 

 

 

 

 

 


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